Driwan Stem CEll THERAPY INFORMATION CENTER (CONTINIU)

 

FOUNDER
 
Dr Iwan Suwandy,MHA
more infocontact
 
iwansuwandy@ gmail.com
all free of charge
this info to all human in the world
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THE MIGHTY GOD BLESS
 
 

Mast cell homeostasis: a fundamental aspect of allergic disease

JJ Ryan, M Kashyap, D Bailey… – Critical Reviews™ in …, 2007 – dl.begellhouse.com
 One also wonders if part of the clinical efficacy of anti-IgE therapy is related to regulat- ing mast
cell life span  TGF-β1 has been shown to inhibit IL-3-depen- dent proliferation of peritoneal mast
cells and BMMC.92,93 In addition, TGF-β1 inhibited stem cell factor-mediated 

Reversing breast cancer stem cell into breast somatic stem cell

L Wijaya, D Agustina, AO Lizandi… – Current …, 2011 – ingentaconnect.com
 Tel: +62 21 47860173/57869756; Fax, +62 21 47860180; E-mails: fsandra@sci-indonesia.org;
ferrysandra  In this regard, several groups have studied the capability of embryonic stem cell
micro- environments to reprogram the phenotype of cancer cells [49]. 

Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial

AP Phyo, KM Lwin, RN Price… – Clinical infectious …, 2011 – cid.oxfordjournals.org
 island of New Guinea [4–6]. The degree of CQ resistance in Papua, Indonesia and Papua  More
recently, CQ-resistant P. vivax has been documented across the Indonesian archipelago [1] and
in  1% packed red blood cells, as the number of parasites per 500 white blood cells

Hungary detains 4 over illegal stem cell treatment

K Than, MOA Boy, I Shock – Reuters, available at, 2009 – stemcellresearchnews.com
 “Nowhere in the world is this used as therapy and on a  It said only Hungary’s Healthcare Scientific
Council has the authority to issue permission to conduct stem cell research.  Stem cells are the
body’s ‘master cells‘, the source of all cells and tissue, including brain, blood, heart 

… and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South Sumatra, Western Indonesia: an open-label, …

I Sutanto, S Suprijanto, A Kosasih… – Clinical infectious …, 2013 – cid.oxfordjournals.org
 All treatment doses were given as directly observed therapy by the healthcare attendants.  in the
study, and fulfilled standards for good manufacturing practices in China and Indonesia,
respectively.  and expressed per microliter assuming a leukocyte count of 8000 cells/µL blood. 

Evaluation of crucial factors for implementing shed-microspore culture of Indonesian hot pepper (< i> Capsicum annuum</i> L.) cultivars

EDJ Supena, W Muswita, S Suharsono… – Scientia horticulturae, 2006 – Elsevier
 anther-culture-derived potato plants (Singsit and Veilleux, 1991) and of regenerated cell– and
tissue  We used also other Indonesian large type hot pepper varieties ‘Gada’, ‘Prabu’ and  which
were grown in the breeding company East West Seed Indonesia (EWINDO) Purwakarta 

Survey and analysis of satellite-based telemedicine projects involving Japan and developing nations: investigation of transmission rates, channel numbers, and node …

I Nakajima, M Natori, M Takizawa… – Studies in health …, 2001 – IOS Press
 program exchange, the National Kumamoto Hospital provided a program on adult T-cell leukemia
to Indonesia, while the Indonesian Unjani Hospital  Detailed information on bone-marrow stem
cell transplants is provided by the Medical Information Department of Shinshu 

Acquired sideroblastic anaemia after aplastic anaemia caused by D-penicillamine therapy for rheumatoid arthritis.

AC Ramselaar, AW Dekker, O Huber-Bruning… – Annals of the …, 1987 – ard.bmj.com
 Case report A 68 year old Indonesian man had a five year history of seropositive  there was a
moderately active toxic granulopoiesis with a left shift and sporadic blast cells with rheumratoid
arthritis.’ In these reports, hoxever,there were no fealtures of stem cell injury such as the 

[PDF] Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells

D Kong, S Aoki, Y Sowa, T Sakai, M Kobayashi – Marine drugs, 2008 – mdpi.com
 smenospongine, a sesquiterpene aminoquinone, from the Indonesian marine sponge
Dactylospongia elegans.  Smenospongine was isolated from the marine sponge Dactylospongia
elegans (collected in Indonesia in 2001) as described previously [12].  Stem Cells Dev. 

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre‐chemotherapeutic osteosarcoma cell line ( …

BP Pereira, Y Zhou, A Gupta, DT Leong… – Journal of cellular …, 2009 – Wiley Online Library
 osteosarcoma cell lines (OS1, OS2 and OS3) were developed from bone tumour biopsies from
patients of, respectively, Singaporean Chinese (OS1) and Indonesian Chinese (OS2  To examine
the phenotypic state of OS1 cells from a mesenchymal stem cell perspective, we 

Combined radiotherapeutic and surgical management of a spinal cord compression by extramedullary hematopoiesis in a patient with hemoglobin E beta-thalassemia

KH Shin, S Sharma, SJ Gregoritch, RM Lifeso… – Acta …, 1994 – karger.com
 a pale, jaundiced 22-year-old male of mixed Dutch-Indonesian heritage presented  A), with
decreased red cell production, microcytosis and decreased red cell survival.  as erythrocytes and
granulocytes, are relatively radioresistant, mitotic cells (especially stem cells) are highly 

Increased cell viability and proliferation in post-hypoxic hippocampal tissue culture treated with Acalypha indica root extract

S Yolanda, EW Bachtiar, N Ibrahim – Medical Journal of Indonesia, 2011 – mji.ui.ac.id
 of Physiology, Faculty of Medicine University of Indonesia and Department of Oral Biology, Faculty
of Dentistry University of Indonesia for their  New hope for stroke patients: mobilization of
endogenous stem cells Haas S, Weidner N, Winkler J. Adult stem cell therapy in stroke. 

The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis

B Alisjahbana, E Sahiratmadja… – Clinical Infectious …, 2007 – cid.oxfordjournals.org
 5,6,7,8–9]. We have confirmed the association between DM and TB in Indonesia, which has  In
the era before insulin therapy, patients with DM appeared to be doomed to die of  In a prospective
cohort study in an Indonesian region, we examined whether DM was associated with 

Non-bacterial infections in Asian patients treated with alemtuzumab: a retrospective study of the Asian Lymphoma Study Group

SJ Kim, JH Moon, H Kim, JS Kim… – Leukemia & …, 2012 – informahealthcare.com
 graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplant
(HSCT  who received alemtuzumab plus ICE chemotherapy (ifosfamide, carboplatin, etoposide)
in Indonesia A-DHAP) is effective for relapsed peripheral T-cell lymphoma, unspecified 

[HTML] Quality of life during active treatment for pediatric acute lymphoblastic leukemia

L Sung, R Yanofsky, RJ Klaassen, D Dix… – … Journal of Cancer, 2011 – Wiley Online Library
 ALL: acute lymphoblastic leukemia; CI: confidence interval; SCT: stem cell transplantation; QoL 
two dexamethasone-based protocols named the Wijaya Kusuma and Indonesia ALL protocols. 
Health-related quality of life assessment in Indonesian childhood acute lymphoblastic 

Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts

M Roberge, B Cinel, HJ Anderson, L Lim, X Jiang, L Xu… – Cancer research, 2000 – AACR
 NCI Natural Products Repository extract N29701 was obtained from the stem bark of the tree
Ilex macrophylla in Kalimantan, Indonesia Rhizoxin is very cytotoxic to cancer cells in vitro or
in mice (20 , 30) , including cell lines resistant to the Vinca alkaloids (30) . 

SIOP‐PODC recommendations for graduated‐intensity treatment of retinoblastoma in developing countries

G Chantada, S Luna‐Fineman, RS Sitorus… – Pediatric blood & …, 2013 – Wiley Online Library
 University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 5  However, when
a single aspiration fails to show malignant cells, a more exhaustive bone marrow  with stage IV
disease benefit from more intensive chemotherapy with autologous stem cell rescue 26. 

[PDF] Bone marrow-derived stem cells as an adjunctive treatment for acute myocardial infarction: a systematic review and meta-analysis

RA Kuswardhani, A Soejitno – Acta Med Indones, 2011 – inaactamedica.org
 Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia 2. Wollert KC, Drexler H.
Cell therapy for the treatment of coronary heart disease: a critical appraisal.  3. Leri A, Kajstura
J, Anversa P. Cardiac stem cells and mechanisms of myocardial regeneration. 

Doxycycline Treatment of Brugia malayi—Infected Persons Reduces Microfilaremia and Adverse Reactions after Diethylcarbamazine and Albendazole Treatment

T Supali, Y Djuardi, KM Pfarr… – Clinical infectious …, 2008 – cid.oxfordjournals.org
 Twelve months after the commencement of doxycycline therapy, there was an almost complete 
This European Union—funded collaborative study of European and Indonesian institutions was 
by the Commission of Medical Ethics of the University of Indonesia (Jakarta, Indonesia 

Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia

B Alisjahbana, R Dinata, E Sutedja… – Archives of …, 2010 – archderm.jamanetwork.com
1.

Dusko Ilic explores the latest developments in the field of stem cell research and regenerative medicine

D Ilic – 2008 – Future Medicine
 CordLife (www.cordlife.com), which currently has operations in ten countries, and Indonesian
pharmaceutical giant  However, that will not be the case in Indonesia’s highly seg- mented market
and the  and an annual fee of US$130 will be beyond the means of most Indonesians

[PDF] Climate talks focus on lesser goals

J Tollefson – Nature, 2010 – environmentportal.in
 Indonesia recently announced plans to reduce its emissions by 26% by 2020 com- pared with
predicted levels if emissions were left  cells was difficult for a while, there has been an upsurge
in the commercialization of adult stem cells, with several stemcell therapies now in 

Autologous recovery with protractedly undetectable donor chimerisms can precede stable donor engraftment in a nonmyeloablative cord blood transplant

WHY Khee, PTH Chye, TC Hoe, HG Fung… – International journal of …, 2003 – Springer
 posttransplantation but developed pneumo- nia 8 months later after he had returned to his home
in Indonesia cord blood transplantation for treating multiple myeloma in which an absence of
detectable donor cells by VNTR analy- sis 4 weeks after stem cell infusion was 

[PDF] US Food and Drug Administration international collaborations for cellular therapy product regulation

JA Arcidiacono, JW Blair… – … cell research & therapy, 2012 – biomedcentral.com
 including Australia, Canada, China (Hong Kong), Chinese Taipei the European Union, Indonesia,
Japan, Pan  This article is part of a thematic series on Clinical applications of stem cells edited
by  Stem Cell Research & Therapy 2012, 3:38 http://stemcellres.com/content/3/5/38 

Key gaps in the knowledge of< i> Plasmodium vivax</i>, a neglected human malaria parasite

I Mueller, MR Galinski, JK BairdJM Carlton… – The Lancet infectious …, 2009 – Elsevier
 of vivax malaria as relatively benign compared with falciparum malaria might stem in part  32 The
risk of therapeutic failure drops as you move north across western Indonesia and into  is a
substantial threat to health on the Malaysian peninsula, the Indonesian archipelago, and 

[PDF] Pharmacogenetic application in personalized cancer treatment

H Kristyanto, AR Utomo – Acta Med Indones, 2010 – inaactamedica.org
 Jl. Salemba 6 Jakarta Pusat 10430, Indonesia. ** Stem Cell and Cancer Institute, Jakarta.  Mutations
in the KRAS gene are found in approximately 15 to 30% of patients with non-small cell lung cancer
(NSCLC) and 40 to 45% of patients with MCRC, and their presence typically 

Idiopathic CD4 lymphocytopenia

UA Walker, K Warnatz – Current opinion in rheumatology, 2006 – journals.lww.com
 of review: A severe decrease of CD4 T cells predisposes humans to opportunistic infections.
In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes,
such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and 

End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening disease

MG Ison, MD de Jong, KJ Gilligan… – Journal of Infectious …, 2010 – jid.oxfordjournals.org
 of morbidity and mortality than that found in recipients of autologous stem cells [18], and  For
example, one study of hematopoietic stem cell transplantation (HSCT) recipients found that most 
In hospitalized H5N1-infected patients in Vietnam and Indonesia, levels of viral RNA in 

Cross-linking of plant cell walls with dehydrated fructose by smoke-heat treatment

T Hayashi, YW Park, A Isogai, T Nomura – Journal of wood science, 2008 – Springer
 the kiln-drying method.14 Huge amounts of plant cell wall material are wasted worldwide, and
the cell walls are  Because no use has been devised for the oil palm stem waste, a huge amount
of waste (about 8.5 million carbon tons per year in Malaysia and Indonesia) is either 

[HTML] Prospect of induced pluripotent stem cell Genetic repair to cure genetic diseases

J Adiwinata Pawitan – Stem cells international, 2012 – hindawi.com
 Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
C. Chapon, WA Jones, and KK Bhakoo, “Homing of stem cells to sites  injury after intracerebral
and intravenous administration: a longitudinal imaging study,” Stem Cell Research and 

[HTML] Myeloid antigen expression in childhood acute lymphoblastic leukemia and its relevance for clinical outcome in Indonesian ALL-2006 Protocol

E Supriyadi, AJP Veerman, I Purwanto, J Cloos – Journal of oncology, 2012 – hindawi.com
 obvious in situation with lower EFS and LFS, which is the case in Indonesia In summary, myeloid
antigen expression is common and occurs in 25% of Indonesian children with  Singer, JW Adamson,
et al., “Acute nonlymphocytic leukemia: heterogeneity of stem cell origin,” Blood 

International Health Law

J Todres, PL Marcogliese – The International Lawyer, 2005 – JSTOR
 confront avian influenza with Thailand, Indonesia, Malaysia, Singapore, and the Philippines each
responsible for coordinating specific measures to address the disease  Stem Cell Research  ducted
on embryonic and adult stem cells will yield treatments capable of curing serious 

Simple lipoaspirate washing using a coffee filter

JA Pawitan – Asian Biomed, 2013 – abm.digitaljournals.org
 A preliminary study was reported as an oral presentation at the Scientific Meeting of the Indonesian
Anatomist Association, which took place in Denpasar, Bali, Indonesia, October 12–13, 2012.
The authors have no conflict of interest to report.  Stem Cells. 2006; 24: 376-85.

Methotrexate treatment for type 1 (reversal) leprosy reactions

G Biosca, S Casallo… – Clinical Infectious …, 2007 – cid.oxfordjournals.org
 cases have been concentrated in only 6 countries: India, Brazil, Burma, Indonesia, Madagascar,
and  Type 1 leprosy reactions (ie, reversal reactions) indicate a change in cell-mediated immunity 
The treatment of choice is corticosteroid therapy (prednisolone, 40–60 mg per day 

[PDF] Spontaneous bone regeneration after mandible resection in a case of ameloblastoma—a case report

D Coen Pramono – Ann Acad Med Singapore, 2004 – annals.edu.sg
 Prof. Dr. Moestopo 47, Surabaya, Indonesia Classically, they are considered to undergo
differentiation from a common pool of stem or osteoprogenitor cells located perivascularly in  This
model entails the division of a stem cell to yield 2 progenies, one of which remains as a 

Has Oseltamivir been shown to be Effective for Treatment of H5N1 Influenza?

RB Couch, BR Davis – Journal of Infectious Diseases, 2010 – jid.oxfordjournals.org
 on terminal bronchioles and lung alveolar cells, and not on the epithelial cells of the  These results
are similar to those reported earlier for Indonesia and Vietnam but complemented those  150 mg
twice daily) and a longer duration (7–10 days) or parenteral therapy with peramivir 

Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses

T Woodberry, G Minigo, KA Piera… – Journal of Infectious …, 2008 – jid.oxfordjournals.org
 trials of chloroquine and sulfadoxinepyrimethamine therapy or artemisinin combination therapy
(ACT) after  of Health Research and Development, Ministry of Health, Jakarta, Indonesia; the
Menzies  E. coli host cell protein content was determined using an immunoenzymometric 

Cytotoxic and nitric oxide inhibitory activities of methanol extracts of Garcinia species

ML Jabit, FS Wahyuni, R Khalid, DA Israf… – Pharmaceutical …, 2009 – informahealthcare.com
 of the Institute of Bioscience, Universiti Putra Malaysia, and Rusdi Tamin of Andalas University,
West Sumatra, Indonesia About 100 g each of the sample (leaf, stem, bark and fruit) was ground
to  The cell concentrations were set at 3,000, 4,000, and 2,500 cells/well, respectively 

The relationship between periodontal diseases and diabetes: an overview

WA Soskolne, A Klinger – Annals of Periodontology, 2001 – Am Acad Periodontology
 (2013) Stem cells, tissue engineering and periodontal regeneration.  (2011) Periodontitis
Prevalence and Severity in Indonesians With Type 2 Diabetes.  Cell Biochemistry and
Function 23:5, 333. TO Georgiou, RI Marshall and PM Bartold. 

Cytotoxic therapy for severe avian influenza A (H5N1) infection

JI Henter, CB Chow, CW Leung, YL Lau – The Lancet, 2006 – Elsevier
 and Vietnam, whereas the viruses isolated in mainland China and Indonesia generally still  on
corticosteroids, etoposide, cyclosporine A, and intrathecal methotrexate, followed by stem cell
transplantation for  is important for the initiation of apoptosis in target cells, and later in 

[PDF] Reactivation of hepatitis B virus associated with chemotherapy and immunosuppressive agent

I Wijaya, I Hasan – Acta Med Indones, 2013 – inaactamedica.org
 Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine  to and continue to at
least 12 week after chemotherapy.26 Perhimpunan Peneliti Hepatologi Indonesia (PPHI) 2006 
Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus 

[PDF] New research developments increase therapeutic options for thyroid cancer and bone pain palliation

JE Williams – Journal of Nuclear Medicine, 1997 – Soc Nuclear Med
 a material which is so specific and so lethal to cancer cells,―says  are located in Bombay and
New Delhi, India; Ljubljana,Slovenia;Bandung,Indonesia;andSouthAmerica.  rapidexcretionfromthe
body, which might allow greater success with peripheral blood stem cell support of 

Gonadal malignancy in 13 consecutive collected patients with disorders of sex development (DSD) from Semarang (Indonesia)

AZ Juniarto, BA Setyawati, IP Miranti… – Journal of clinical …, 2013 – jcp.bmj.com
 Indonesian DSD patients with ambiguous genitalia or any anatomical abnormality of external
or internal  4 (OCT3/4), Testis-specific Y-encoded protein 1 (TSPY), VASA, stem cell factor (SCF 
were done at the departments of pathology at Diponegoro University, Indonesia and at 

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

DC Vinh, F Masannat, RB Dzioba… – Clinical Infectious …, 2009 – cid.oxfordjournals.org
 lower lobe mass with mediastinal and hilar lymphadenopathy compromising the main stem bronchi
and  leading to over-accumulation of mutant IFN-γR1 on the cell surface, which  in IL-12/IFN-gamma
pathway genes with susceptibility to pulmonary tuberculosis in Indonesia

Mass treatment of treponemal diseases, with particular reference to syphilis and yaws

T Guthe, FW Reynolds, P Krag, RR Willcox – British medical journal, 1953 – ncbi.nlm.nih.gov
 A portion of the synovial mem- brane of the left ankle shows infiltration by leukaemic stem cells
an ankle-joint looked normal at necropsy, but was found on histological examination to be
infiltrated by immature leukaemic cells.No evidence  2,270,051 2,270,051 Indonesia (yaws 

Treatment perspectives for the lysosomal storage diseases

GA Grabowski – 2008 – informahealthcare.com
 greatest number of LSD patients should be in China, India and the Indonesian Regions.  Currently,
we have little to offer these patients, except stem cell transplantation in a few  1. Schematic of the
lysosomal enzyme synthesis and targeting systems in mammalian cells (continued 

The hematopoietic stem cell transplantation in Indonesia: an unsolved dilemma

H Hariman – Bone marrow transplantation, 2008 – nature.com
 in the government hospitals in Singapore or Malaysia after having the initial treatment done in
Indonesia hospitals in neighbouring countries becomes more important when they use the PBSC
as source of stem cells Post-transplant problems faced by Indonesian hematologists. 

Expression of human α (1, 3) fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells

BW Weston, KM Hiller, JP Mayben, GA Manousos… – Cancer research, 1999 – AACR
 In this report, we will show that this variant cell line expresses increased levels of  to examine the
putative role of FUT genes in the metastasis of colon carcinoma cells the function of human
fucosyltransferases and to provide target validation for potential molecular therapy

Scientometric Analysis of Stem cell Research: A comparative study of India and other countries

R Karpagam, S Gopalakrishnan, BR Babu… – COLLNET Journal of …, 2012 – Taylor & Francis
 The members of SNAP are Australia, China, India, Indonesia, Japan, Taiwan, Thailand, Singapore 
focus on the holding of workshops and training programs on stem cell research and  tions,
commercialisation issues and best practices for GMP facilities for cell processing and 

[BUKU] Adipose Stem Cells and Regenerative Medicine

YG Illouz, A Sterodimas – 2011 – Springer
 life sci- entists, and physicians from Brazil, Canada, France, Germany, Greece, Indonesia, Israel,
Italy  Also included are chap- ters on adipose stem cells as therapeutic delivery tools for  to the
safety and ethics consider- ations for developing adipose stem cell-based therapies

Driwan Stem CEll THerapy Information CEnter (continiu)

 

FOUNDER
 
Dr Iwan Suwandy,MHA
more infocontact
iwansuwandygmail.com
all free of charge
this info to all human in the world
with
 
THE MIGHTY GOD BLESS
 
 

[HTML] The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells

PR SanbergDJ Eve, AE Willing… – Cell …, 2011 – cognizantcommunication.com
 International, Inc., Saneron is committed to providing readily available, noncontroversial stem
cells for cellular  relating to our platform technology of umbilical cord blood and Sertoli cellsCell
PRAXIS Bioengenharia is a platform corporation dedicated to translating research into 

Trends of hematopoietic stem cell transplantation in the third millennium

A Gratwohl, H Baldomero – Current opinion in hematology, 2009 – journals.lww.com
 Use of HSCT is under discussion for nonhematopoietic indications, as is the use of
nonhematopoietic stem cells for organ repair.  This will be of increasing importance, since stem
cell therapy has become a treatment vision for many patients with diseases that are not yet 

Application of a modified method for stem cell isolation from lipoaspirates in a basic lab

CT Sardjono, M Setiawan, F Frisca, V Saputra… – … Journal of Indonesia, 2009 – mji.ui.ac.id
 This report clearly has shown the urge for stem cell research to be conducted in Indonesia as
soon as possible  This study has demonstrated that it is possible to isolate mesenchymal stem
cells from the lipoaspirate using a  Lipoaspirate is truly rich with Mesenchymal Stem cell

Treatment of acute lymphoblastic leukemia

CH Pui, WE Evans – New England Journal of Medicine, 2006 – Mass Medical Soc
 Allogeneic Hematopoietic StemCell Transplantation.  prevention of traumatic lumbar punctures,
especially at diagnosis, when most patients have abundant circulating leukemia cells.95,97  to
imatinib.99 Imatinib may also benefit a subgroup of patients who have T-cell ALL with 

[PDF] Adult bone marrow stem cells in cartilage therapy

AM Lubis, VK Lubis – Acta Medica Indonesiana, 2012 – inaactamedica.org
Page 1. REVIEW ARTICLE 62 Acta Medica Indonesiana – The Indonesian Journal of Internal
Medicine  4, Jakarta, Indonesia. Correspondence mail: andri_lubis@yahoo.com. 2 Innogene
Kalbiotech, Pte.Ltd., Jakarta, Indonesia Stem Cells. 2007;25:2964-71. 32. 

Screening of Indonesian medicinal plants for inhibitor activity on nitric oxide production of RAW264. 7cells and antioxidant activity

EM Choi, JK Hwang – Fitoterapia, 2005 – Elsevier
 In this study, we investigated several medicinal plant extracts traditionally and commonly used
in Indonesia, and focused our  Effects of Indonesian plants methanol extracts on NO production
and viability of RAW264.7 cells Alstonia scholaris, Stem bark, 13.0, 50, −9.4±9.4, 71.5±0.5 

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

E Giovannetti, DG Ugrasena, E Supriyadi, L Vroling… – Leukemia research, 2008 – Elsevier
 can be treated), it might represent an undertreatment for Indonesian children, who  the required
higher dose of MTX in paediatric patients of Indonesia might be  and thymidylate synthase
genotypes modify oral mucositis severity following hematopoietic stem cell transplantation. 

Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives

H Zhang, D Yee, C Wang – 2008 – Future Medicine
 Recent and future progress on tracking therapeutic stem cells with QDs for treating cardiovascular
diseases  can measure levels of molecular targets quantitatively on the tumor cell surface will  Finally,
targeted therapy against an overexpressed molecular target will be used on 

[HTML] Development of Histocompatible Primate‐Induced Pluripotent Stem Cells for Neural Transplantation

M Deleidi, G Hargus, P Hallett, T Osborn… – Stem Cells, 2011 – Wiley Online Library
 with N 2 -A (Stem Cell Technologies, Vancouver, BC, Canada, www.stemcell.com  and MF
66-02) (Supporting Information Table 1). Dermal fibroblasts from an Indonesian CM (MF  under
Good Manufacturing Practice, would be of great value to evaluate stem cell-based therapies 

Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria inIndonesians who lack clinical immunity

MD Lacy, JD Maguire, MJ Barcus… – Clinical Infectious …, 2002 – cid.oxfordjournals.org
 Diseases, National Institute of Health Research and Development, Ministry of Health, Republic
of Indonesia, Jakarta, Indonesia Atovaquone/proguanil provided safe, well-tolerated, and effective
therapy for uncomplicated malaria in nonimmune Indonesians
 

HTML] Prospect of cell therapy for Parkinson’s disease

JA Pawitan – Anatomy & cell biology, 2011 – synapse.koreamed.org
 Salemba 6, Jakarta 10430, Indonesia Tables. Table 1 Various studies on cell therapy in animal
models and patients eNCSCs, epidermal neural crest stem cells; BM-SCs, bone marrow stem
cells; hESCs, human embryonic stem cells; RPE, retinal pigment epithelium. 

Pigmentation PAX‐ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease

JD Kubic, KP Young, RS Plummer… – Pigment cell & …, 2008 – Wiley Online Library
 syndromes resulting from either too much or too little Pax3 function. Due to its key
task in melanocyte stem cells and tumors, the Pax3 pathway may provide an ideal
target for either stem cell or cancer therapies. Introduction. 

Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combinedtherapy on reversing degeneration of the intervertebral disc

HT Hee, HD Ismail, CT Lim… – Journal of Bone & …, 2010 – bjj.boneandjoint.org.uk
 Siregar, and her staff in Eijkman Institute for Molecular Biology, Jakarta, Indonesia: L. Yunaini,
Nur Ita M, and M. Rusdi H, for  Differentiation of mesenchymal stem cells transplanted to a rabbit
degenerative disc model: potential and limitations for stem cell therapy in disc 

Novel agents and strategies for treatment of< i> p53</i>-defective chronic lymphocytic leukemia

MR Grever, DM Lucas, AJ Johnson, JC Byrd – Best Practice & Research …, 2007 – Elsevier
 Allogeneic stemcell transplant likely represents the only curative therapy for CLL.  pentostatin,
and/or alemtuzumab – has resulted in the ability to engraft allogeneic cells from a related  has
increased the number of CLL patients eligible for allogeneic immune therapy to patients 

A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis

E Villamor, F Mugusi, W Urassa… – Journal of Infectious …, 2008 – jid.oxfordjournals.org
 One trial in Indonesia suggested a potential beneficial effect of vitamin A and zinc on early sputum
smear conversion  Effect of micronutrient supplementation on T cell counts (cells/mm 3 ) and viral
load (copies/mm 3 ).  In a study of 80 Indonesians with pulmonary TB, Karyadi et al 

… , placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia

J Ling, JK Baird, DJ Fryauff, P Sismadi… – Clinical infectious …, 2002 – cid.oxfordjournals.org
 double-blinded trial of atovaquone/proguanil for malaria prophylaxis in Indonesians who did
not  village, a mixture of people from Java, other islands of Indonesia, or the  chloroquine,
pyrimethamine/sulfadoxine, or quinine therapy, consistent with the Indonesian national malaria 

[HTML] Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents

E Meiyanto, A Hermawan… – Asian Pacific Journal of …, 2012 – koreascience.or.kr
 The Anti-Tumor Effect of Doxorubicin on Hela Cervical Cancer Cells Through Cytotoxic Activity
and Apoptosis Induction, Indonesian J Cancer  (In Indonesia).  and YB-1 Expression Plays a Role
In Increased Heterogeneity of Breast Cancer Cells: Correlations with Cell Fusion and 

Encephalomyelitis Due to Infection with Herpesvirus simiae (Herpes B Virus) A Report of Two Fatal, Laboratory-Acquired Cases

K Hummeler, WL Davidson, W Henle… – … England Journal of …, 1959 – Mass Medical Soc
 Basic principles for stem cell culture. In: Progenitor and stem cell technologies and therapies
6. John R Masters, Glyn N Stacey. (2007) Changing medium and passaging cell lines.  (2005)
Prevalence of enzootic simian viruses among urban performance monkeys in Indonesia

Indonesian tea mistletoe (Scurrula oortiana) stem extract increases tumour cell sensitivity to tumour necrosis factor alpha (TNFα)

R Murwani – Phytotherapy Research, 2003 – Wiley Online Library
 The stem extract showed a greater increase than the leaf extract, increasing the sensitivity more 
Indonesian tea mistletoe (‘benalu teh’) (Family Loranthaceae) is a parasitic plant that grows on 
In Indonesia, especially in Java, its potency as an (indigenous) anti-tumour agent has 

Stem cell stratagems in alternative medicine

D Sipp – Regenerative medicine, 2011 – Future Medicine
 121 . BRCO Stem Cell Indonesia http://xenostemcell-indonesia.com. 122 .  123 . Stem Cell
Biomedics www.stemcell-biomedics.com. 124 . Fetal Stem Cell International medical advisory
panel http://www.fetal-cells.com/index.php?Content=advisory. 125 . 

In the Literature

WJ Burman, S Goldberg, JL Johnson – tuberculosis, 2006 – cid.oxfordjournals.org
 The authors caution, however, against the reinstitution of chloroquine as standard therapy for
malaria in Malawi, because this country is surrounded by other countries in  Human H5N1 Infection
In Indonesia And Turkey.  Three Indonesian clusters of H5N1 virus infection in 2005. 

[BUKU] Advanced therapy in cardiac surgery

KL Franco, ED Verrier – 2003 – books.google.com
 com Singapore, Malaysia, Thailand, Philippines, Indonesia, Vietnam, Pacific Rim, Korea Elsevier
Science Asia  PhD, Barbara Cattadori, MD, MS, Alain Carpentier, MD, PhD 44 Cell Therapy for
Myocardial  E. Beschorner, MD 60 Role of Gene Therapy and Stem Cells in Cardiac 

[PDF] Isolation and cultivation of mesenchymal stem cells from iliac crest bone marrow for further cartilage defect management

AM Lubis, L Sandhow, VK Lubis, A Noor… – Acta Med …, 2011 – inaactamedica.org
 study has been approved by Ethical Committee of the Faculty of Medicine University of
Indonesia/Cipto Mangunkusumo  E, McGonagle D, Scutt A. Age-related changes in human bone
marrow-derived mesenchymal stem cells: consequences for cell therapies

C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-basedtherapy personalisation

E De Mattia, G Toffoli – European Journal of Cancer, 2009 – Elsevier
 These data could suggest that the C677T polymorphism differentially modulates the sensitivity
of cancer cells to MTX, depending upon the specific cell type. 64 In view of the importance of
MTX in the therapy of adult and paediatric lymphoid malignancies, particularly during 

Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen)

AR Han, JA Kim, DD Lantvit, LBS Kardono… – Journal of natural …, 2009 – ACS Publications
 Research Center for Biology, Indonesian Institute of Science  stem bark of G. mangostana (400
g) was collected at Pangradin village, Jasinga, West Java, Indonesia, in August  Extraction and
Isolation The dried stem bark of G. mangostana (400 g) was extracted with MeOH (3 × 1 

Primaquine therapy for malaria

JK Baird, SL Hoffman – Clinical infectious diseases, 2004 – cid.oxfordjournals.org
 Vivax malaria is especially common in India, Indochina, and the Philippine, Indonesian and New 
ovale malaria occurs only in West Africa, The Philippines, Eastern Indonesia, and Papua  when
given concurrently with blood schizonticides [40–42] (table 2). Indonesians who took 

Platelet rich plasma in xeno-free stem cell culture: the impact of platelet count and processing method

J Adiwinata Pawitan – Current stem cell research & therapy, 2012 – ingentaconnect.com
 This study is funded by the grant from the Directorate of Research and Community Service of
Universitas Indonesia 2012, Contract no.1594/H2.R12/HKP.05.00  Internalized antigens must
be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene 

Dissecting the molecular pathways of (testicular) germ cell tumour pathogenesis; from initiation totreatment‐resistance

LHJ Looijenga, AJM Gillis, H Stoop… – … journal of andrology, 2011 – Wiley Online Library
 or differentiation, resulting in loss of characteristics of embryonic germ – and stem cells, or a  that
in spite of this cancer being rare in the general Indonesian population, in  Interestingly, in
Drosophila communication between soma and germ cell initiating germ line sexual identity 

[BUKU] Essential haematology

V Hoffbrand, P Moss – 2011 – books.google.com
 1996, 1997, 1998, 1999, 2000 Fourth edition 2001 German 2002 Indonesian 2005 Korean  62
■VitaminB 12 deficiency 63 ■ Folate deficiency 64 ■ Tissue-specific stem cells 5 ■
Theregulation  factors 6 ■ Growth factor receptors and signal transduction 8 ■ The cell cycle 

Results of a prospective study for the treatment of unilateral retinoblastoma

GL Chantada, AC Fandiño, MR Guitter… – Pediatric blood & …, 2010 – Wiley Online Library
 Choroidal invasion was categorized as full when tumor cells invaded the choroid >50% of it  of
treatment was significantly associated to poor prognosis in an Indonesian series 27  could be
rescued with chemotherapy followed by intensification and autologous stem cell rescue. 

[PDF] Immunophenotypic patterns of childhood acute leukemias in Indonesia

YM Purwanto, S Gunawan… – Asian Pacific Journal …, 2011 – apocpcontrol.com
 until July 2010 were received from Pediatric Cancer Units (PCU) of four Indonesian teaching
hospitals  Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias.  Purwanto
I, et al (2011) Incidence of childhood leukemia in Yogyakarta, Indonesia, 1998 – 2009. 

Updates on current advances in gene therapy.

J Tani, JT Sufian – West Indian Medical Journal, 2011 – search.ebscohost.com
 Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
and 3Peking  59) in order to confer specific protection against HIV infection to these cells Both
clinical T cell and haemato- poietic stem cell gene transfer trials have demonstrated 

Current status of hematopoietic stem cell transplantation in Taiwan

PM Chen, LT Hsiao, MH Chen, PMS Chang… – Bone marrow …, 2008 – nature.com
 Transfusion of donor peripheral blood buffy coat cells as effective treatment for relapsed acute
leukemia after transplantation of allogeneic bone marrow or peripheral blood stem cells from
the  The hematopoietic stem cell transplantation in Indonesia: an unsolved 

[HTML] Transgenic animals: Their benefits to human welfare

ET Margawati – American Institute for Biological Sciences, 2003 – actionbioscience.org
 isolation of totipotent stem cells (stem cells that can develop into any type of specialized cell) from
embryos; the desired gene is inserted into these cells D and is now working at the Research Centre
for Biotechnology, the Indonesian Institute of Sciences , Indonesia

Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562cells

S Aoki, D Kong, K Matsui, M Kobayashi – Anti-cancer drugs, 2004 – journals.lww.com
 leukemia (CML) arises from chromosomal abnormality in a pluripotent hematopoietic stem cell
further isolated smenospongine, a sesquiterpene aminoquinone, from an Indonesian marine
sponge.  from the marine sponge Dactylospongia elegans (collected in Indonesia in 2001 

… association of interleukin-6 and lipopolysaccharide-binding protein with severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients

M Haarbrink, GK Abadi, WA Buurman… – Journal of Infectious …, 2000 – jid.oxfordjournals.org
 the inflammatory processes via both the monocyte/macrophage or the T cell—stimulation route. 
We gratefully acknowledge the assistance in Indonesia of Abdul Jalil, Abdul Rashid, Sidra  and
blood withdrawal, in accordance with the guidelines of the Indonesian Department of 

Stem cells and regenerative medicine on the Asian horizon: an economic, industry and social perspective

D Sipp – Regenerative medicine, 2009 – Future Medicine
 in which stem cell research is minimal, including Thailand, the Philippines, Indonesia and Malaysia 
Theravitae, a company based in Bangkok, Thailand, offers autologous stem cell therapies for
congestive heart failure and peripheral vascular disease, sending the cells to Israel 

[PDF] Umbilical Cord Blood: the Future of Stem Cell Research?

E Lloyd – National Geographic News, 2006 – cordlife.com
 CORDLIFE SINGAPORE BIOCELL AUSTRALIA CORDLIFE HONG KONG CORDLIFE INDONESIA
CORDLIFE PHILIPPINES  cell technology will come from and what kinds of stem cells will be 
President George W. Bush signed into law the Stem Cell Therapeutic and Research 

The pathogenesis of rheumatoid arthritis

IB McInnes, G Schett – New England Journal of Medicine, 2011 – Mass Medical Soc
 into adipocytes, chondrocytes, and osteoblasts, can be detected in the synovium.80,81 However,
the biologic characteristics of synovial mesenchymal stem cells, their relationship  Cellcell
interactions in synovitis: interactions between T lymphocytes and synovial cells

Emerging chloroquine-resistant Plasmodium vivax (Benign Tertian) malaria: the need for alternative drug treatment

JM Vinetz – Clinical Infectious Diseases, 2006 – cid.oxfordjournals.org
 latent liver forms (hypnozoites), necessitating an additional course of primaquine therapy (after
assessing  chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria
in Papua, Indonesia Malaria in a cohort of Javanese migrants to Indonesian Papua. 

Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia: results of the Malaysia-Singapore Leukemia Study Group

H Ariffin, SP Chen, CS Kwok, TC Quah… – Journal of pediatric …, 2007 – journals.lww.com
 from Malaysia and Singapore (mostly Malay and Chinese), and also Indonesia, Brunei, and  Total
RNA was extracted from leukemic cells by Trizol reagent (Invitrogen, Carlsbad, CA  Leukemic
cell lines positive for the respective chromosomal alterations 15 were included, while 

[PDF] … granulocyte colony stimulating factor and erythropoetin based-stem cell therapy using intracoronary infusion of peripheral blood stem cells in patients with …

T Santoso, C Irawan, I Alwi, A Aziz, A Kosasih… – Acta Med …, 2011 – inaactamedica.org
 Medistra Hospital, Jakarta, Indonesia. Correspondence mail to: tsantoso@cbn.net.
id  G-CSF-based stem cell therapy has been proposed as a practical and non-invasive
alternative to stem cell therapy using bone marrow stem cells

Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature

BJ Currie, DA Fisher, DM Howard… – Clinical Infectious …, 2000 – cid.oxfordjournals.org
 Burma (Myanmar) and was recognized in patients in Vietnam and Indonesia decades before 
The clinical presentations of brain stem encephalitis with peripheral motor weakness, including
acute  when there is coinfection with HIV, suggesting that CD4 cell-mediated defense 

Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia

JD Maguire, H Marwoto, TL Richie… – Clinical infectious …, 2006 – cid.oxfordjournals.org
 on clearance of parasitemia and clinical cure in the face of ineffective chloroquine therapy during
the intervening period, because mefloquine has not been available in Indonesia and, therefore,
is not a factor in the development of selective resistance in Indonesian Papua. 

Influenza surveillance in Indonesia: 1999–2003

CG Beckett, H Kosasih, C Ma’roef… – Clinical infectious …, 2004 – cid.oxfordjournals.org
 All participants were Indonesian and residents of each sentinel city of surveillance.  mnRT-PCR)
for detection of influenza viruses, compared with virus isolation using cell culture  In particular,
because Indonesia straddles the equator, virological surveillance data could be used to 

Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua,Indonesia

JK Baird, MD Lacy, H Basri, MJ Barcus… – Clinical infectious …, 2001 – cid.oxfordjournals.org
 Blood cell counts were analyzed (Becton Dickinson QBCII Plus Analyzer system and reagents),
as  gratitude to many officers of the Ministry of Health, Republic of Indonesia, for their  This study
was reviewed and approved by American and Indonesian committees for the ethical 

Stem cell transplantation programme at Singapore General Hospital

MBC Koh, YT Goh, PHC Tan, LP Koh… – Bone marrow …, 2008 – nature.com
 Exp Haem 2005; 33: 671–681. Suck G. Novel approaches using natural killer cells in cancer therapy
REVIEWS. The hematopoietic stem cell transplantation in Indonesia: an unsolved dilemma. Bone
Marrow Transplantation Review. See all 10 matches for Reviews. 

Aplasia and leukaemia following chloroquine therapy.

N Nagaratnam, AD Chetiyawardana… – Postgraduate medical …, 1978 – pmj.bmj.com
 2 showing increase of fat spaces with islets of cells (HE, x 100); (b) same, with islets of cells and
fat  In the other, there is a strong suggestion of a stem cell lesion.  Third Meeting of the Inter- national
Society of Haematology, Asian-Pacific Division, June 1975,Jakarta, Indonesia

Antiproliferative effect of the methanol extract of Piper crocatum ruiz & pav leaves on human breast (T47D) cells in-vitro

BD Wicaksono, YA Handoko, ET Arung… – Tropical Journal of …, 2009 – ajol.info
 is traditionally used by Indonesians for treating various diseases, including breast cancer9.  T47D
cells were obtained from the Indonesian Institute of Sciences Research Centre for Chemistry,
Natural Products, Food and Pharmaceuticals Division, Bandung, Indonesia

Estrogen replacement therapy induces telomerase RNA expression in the macaque endometrium

JD Vidal, TC Register, M Gupta, JM Cline – Fertility and sterility, 2002 – Elsevier
 study were adult female cynomolgus macaques (Macaca fascicularis) imported from Indonesia
as subjects  expression, which is consistent with the histopathologic observations of stromal cell
hyperplasia and  layer is shed at menses and is repopulated from stem cells within the 

Driwan Stem CEll therapy Information center

 

FOUNDER
 
Dr Iwan Suwandy,MHA
more infocontact
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The development of stem therapy in Indonesia
Stem Cell Therapy Could Prevent Various Diseases
Qalbinur Nawawi – Okezone
THURSDAY , NOVEMBER 7 2013 14:57 pm
 
The discussion ( Photo : qalbi / Okezone )
THROUGH Dr . Boenjamin Setiawan Distinguished Lecture Series 2013 , Dr . Boenjamin Setiawan, PhD , Chairman of the Scientific Advisory Board of Stem Cell and Cancer Institute , to educate the public about the research and development of health technology . One of them is that stem cell therapy , the results of the latest medical technology and treatment is believed to answer the needs of Indonesia in the future .

 
Stem cells or stem cell is a cell that can reproduce itself and has the ability to differentiate into many cell . Because of this ability , the potential of stem cells to regenerate damaged cells or dysfunction in many diseases and potential to cure many incurable diseases .
 
” Stem cells are the future of medicine and can cope with various diseases .
 In our bodies there are many cells , such as bone marrow and fat cells in our body .
Cells in our own bodies there are 100 trillion cells , and every day there will be a lot of dead and all.
 All it takes is regenerated and the efforts of the solutions come from stem cell therapy , ” said Dr. . Boenjamin Setiawan, PhD , Chairman of the Scientific Advisory Board of Stem Cell and Cancer Institute in the event themed Increasing Quality Life Through Cell Therapy at the University Tarumanagara Main Building , Auditorium Room 3rd Floor , West Jakarta , Thursday ( 07/11/2013 )
 

” Our body is like a car , which is often used when the inevitable damage .
 And it can be fixed with stem cell therapy through the ‘ five R ‘ . First , replacing damaged cells or to repair and replace , then regenerated by stem cell therapy , and the fourth R rehabilitated . Anyway , all the damaged cells enhanced , then finally rejuvenated , “he continued .
 
The biggest benefit of stem cell therapy is very diverse , can make the skin taut and youthful look , then also can cure incurable diseases .
 
” So far , stem cell therapy is still small . RSCM itself which is the reference point of all disease , had stem cell therapy to cure four diseases . Firstly , osteoarthritis handled dr . Andri Lubis , Sp.OT , heart attack or heart , burns , and fractures that do not want to connect – connect , ” he explained .
 
Not merely that, this stem cell therapy can cure degenerative diseases , such as heart failure , cartilage injury , stroke , diabetes , and kidney failure .

 However, to be able to get the formula of the treatment of degenerative it should continue to be extracted by the related parties , primarily academics and practitioners , as well as the government .
The goal is that the more types of diseases that can be cured by this stem cell therapy .
Where indirect already advancing research and development of health technology in Indonesia .
 
” The existence of this educational program and sharing so that existing lecturers in medical school ikutresearch , not just teaching in the classroom .
It was because of the many benefits that can be cured of this cell therapy . I wish health and health technology Indonesian move on and do not be retarded . Do not want to be followers . And to achieve that , the teachers can not only in the classroom alone . They must participate researching , ” he explained .
 
Meanwhile , the education program itself runs from 6-8 November 2013 in Jakarta, which is housed in several large campuses in Jakarta , namely the University of Atma Jaya , Tarumanegara University , University of Indonesia and the peak of the event will be held at the Four Seasons on 9 November 2013 .
( tty )
Dr. . Boenjamin Setiawan, PhD
 
dr . Boenjamin Setiawan, Ph.D.

This is one example of a figure model of health that have multidimensional mindset . Broad insights to help successful reading opportunities .
Consistency will be the nature of his concern for the world of medical research in Indonesia helped memerbanyak existing business opportunities .
Establish a pharmacological company had indeed ideals of the ancients . His experience in fostering research memerkaya helped perpetuate the success of Kalbe Farma road gait .
He is one of the exemplary model of health . Open minded but firm .
Kalbe Farma is the founding manifesto of a sense of love for the field of pharmacology .
Also, concern for the progress of the development of medical science gets a share of attention in developing the health agenda in Indonesia .
 
Not a bit of research it supports . As well as well as some foundations that receive special attention in the advancement of health .
Here are some of them who built the foundation , Foundation for the Development of Human Resources in 1970 and the Foundation for Development of Creativity in 1985 .
Pun , who cultivated many pharmacological companies supported by the results of scientific research in its development process .
He is a multi – dimensionil doctor and has a soul of steel -minded entrepreneurs

Perkembangan stem terapi di Indonesia

Terapi

 Stem Cell 

Bisa Cegah Beragam Penyakit

Qalbinur Nawawi – Okezone

 

 

KAMIS, 7 NOVEMBER 2013 14:57 wib

Acara diskusi (Foto: Qalbi/Okezone)

MELALUI

 Dr. Boenjamin Setiawan Distinguished Lecture Series 2013, Dr. Boenjamin Setiawan PhD, Chairman of Scientific Advisory Board Stem Cell and Cancer Institute, memberikan edukasi kepada masyarakat mengenai perkembangan riset dan teknologi kesehatan. Salah satunya ialah terapi stem cell

, hasil teknologi kesehatan terbaru dan diyakini bisa menjawab kebutuhan pengobatan Indonesia di masa depan.

 

 

 

 

Stem cell atau sel punca merupakan sel yang bisa memperbanyak dirinya dan mempunyai kemampuan untuk berdiferensiasi menjadi banyak sel. Karena kemampuannya ini, stem cell berpotensi untuk meregenerasi sel yang rusak atau disfungsi dalam berbagai penyakit dan potensial untuk menyembuhkan berbagai penyakit yang sulit disembuhkan.
 
Stem cell

 merupakan pengobatan masa depan dan bisa mengatasi beragam penyakit.

Dalam tubuh kita terdapat banyak sel, seperti di sumsum tulang belakang dan sel lemak dalam tubuh kita.

Sel dalam tubuh kita sendiri ada 100 triliun sel dan setiap hari akan ada yang mati dan banyak sekali.

Semua itu butuh diregenerasi dan upaya itu jalan keluarnya datang dari terapi 

stem cell,” kata Dr. Boenjamin Setiawan PhD, Chairman of Scientific Advisory Board Stem Cell and Cancer Institute dalam acara bertema Increasing Quality Life Through Cell Therapy

 di Gedung Utama Universitas Tarumanagara, Ruang Auditorium Lantai 3, Jakarta Barat, Kamis (7/11/2013)
 

 

 

 

“Badan kita itu ibarat mobil, di mana saat sering dipakai pasti terjadi kerusakan.

Dan itu bisa diperbaiki dengan terapi 

stem cell melalui ‘lima R’. Pertama, sel yang rusak diganti atau di-repair dan replace, kemudian diregenerasi melalui terapi stem cell, dan R keempat direhabilitasi. Pokoknya, semua sel yang rusak disempurnakan, kemudian akhirnya diremajakan,” sambungnya.
 
Manfaat terbesar terapi 
stem cell ini sangat beragam, bisa membuat kulit kencang dan tampak awet muda, kemudian juga bisa menyembuhkan penyakit yang sulit disembuhkan.
 
“Sejauh ini, terapi 
stem cell masih sedikit. RSCM sendiri yang merupakan tempat rujukan semua penyakit, sudah terapi stem cell

 untuk penyembuhan empat penyakit. Pertama, osteoartritis yang ditangani dr. Andri Lubis, Sp.OT, serangan jantung atau jantung, luka bakar, dan patah tulang yang tidak mau menyambung-nyambung,” jelasnya.
 

 

Tak sebatas itu, terapi stem cell ini bisa menyembuhkan penyakit degeneratif, seperti gagal jantung, cedera tulang rawan, stroke, diabetes, dan gagal ginjal

.

 

 

Kendati demikian, untuk bisa mendapat formula dari pengobatan degeneratif itu  harus terus digali oleh pihak terkait, utamanya akademisi dan praktisi, serta pemerintah.

 

Tujuannya agar makin banyak jenis penyakit yang bisa disembuhkan oleh terapi 

stem cell ini.

 

Di mana secara tak langsung sudah memajukan perkembangan riset dan teknologi kesehatan di Indonesia.
 
“Adanya program edukasi dan 

sharing ini agar para dosen yang ada pada fakultas kedokteran ikutresearch, bukan hanya sekadar mengajar di kelas.

Hal itu karena banyak manfaat yang bisa disembuhkan dari terapi sel ini. Saya ingin teknologi kesehatan dan kesehatan Indonesia maju terus dan jangan terbelakang. Jangan mau jadi 

follower. Dan untuk mencapai hal itu, para dosen tidak bisa hanya dalam kelas saja. Mereka harus ikut meneliti,” jelasnya.
 

Sementara itu, program edukasi ini sendiri berlangsung dari tanggal 6-8 November 2013 di Jakarta yang bertempat di beberapa kampus besar di Jakarta, yaitu Universitas Atmajaya, Universitas Tarumanegara, Universitas Indonesia dan puncak acara akan dilaksanakan di Hotel Four Seasons pada 9 November 2013

.

(tty)

 

Dr. Boenjamin Setiawan PhD

 

 

 

dr. Boenjamin Setiawan Ph.D.

 

I

nilah salah satu contoh figur tokoh kesehatan yang memiliki pola pikir multidimensional. Wawasannya yang luas membantu sukses membaca peluang yang ada.

Konsistensi akan sifat kepeduliannya pada dunia penelitian medis di Indonesia membantu memerbanyak peluang usaha yang ada.

Mendirikan perusahaan farmakologi merupakan sudah memang cita-citanya dari dahulu. Pengalamannya dalam membina memerkaya penelitian-penelitian turut membantu melanggengkan jalan kiprah kesuksesan Kalbe Farma.

Beliau merupakan salah satu tokoh kesehatan yang patut diteladani. Pikirannya terbuka namun tegas.

Berdirinya Kalbe Farma merupakan manifesto dari rasa kecintaannya pada bidang farmakologi.
Pun, kepeduliannya kepada kemajuan perkembangan ilmu kesehatan mendapatkan porsi perhatian dalam agenda mengembangkan kesehatan di Indonesia.

Tidak sedikit penelitian yang didukungnya. Serta pula beberapa yayasan yang mendapatkan perhatian khusus dalam kemajuan bidang kesehatan.

Berikut diantaranya beberapa yayasan yang didirikannya yakni, Yayasan Pengembangan Sumber Daya Manusia pada tahun 1970 dan Yayasan Pengembangan Kreatifitas pada tahun 1985.

Pun, perusahaan farmakologi yang dibinanya banyak didukung oleh hasil-hasil penelitian ilmiah dalam proses pengembangannya.

Beliau merupakan dokter multi-dimensionil serta memiliki jiwa pengusaha yang bermental baja. []s

Kalbe, The Making of No. 1 Pharma

Kalbe , The Making of No . 1 Pharma
Thursday, June 1, 2006
By : Prih Sarnianto
Through the merger , Kalbe Farma burst into the top ranks of pharmaceutical companies terakbarIndonesia . What are the strengths that enable them become the biggest in the ASEAN region ?
This is the grandest marriage in Indonesian business stage . Through the internal merger , PT Kalbe Farma Tbk . as the surviving company overtake Sanbe Farma fluttering over the years at the peak of the largest pharmaceutical companies in the country .
In fact , more than that . With a market capitalization of U.S. $ 2 billion , the company whose shares are listed on the Jakarta Stock Exchange with code KLBF also establish itself in the top ranks of public companies in Southeast Asia .
In terms of sales , Kalbe result of a merger that grossed $ 267.2 million revenueUS , in the Southeast Asian region is second only to Pfizer and GlaxoSmithKline ( GSK ) is indeed the world pharmaceutical industry giant .
Nevertheless, as a group of pharmaceutical business , Kalbe Group is actually always the biggest .
Understandably , under the umbrella of one ‘s business empire , directly or indirectly there are big names , including Toedjoe star ( Extra Joss producers who enter the ranks of Top 10 Pharmaceutical Companies in Indonesia ) , Hexpharm ( the largest generic drug manufacturer in the 5th Indonesia ) , Saka Farma ( ABC Sakatonic remember ? ) , Mighty Biosciences ( producer Prenagen , Diabetasol , and other health foods ) , Kalbe Morinaga ( leading dairy producer ) , Innogene Kalbiotech ( biotechnology -based drug manufacturer in Singapore ) and Kageo Igar Jaya ( packaging ) .
Mergers involving PT Enseval sebagaisuperholding and three companies listed on the JSE – Kalbe Farma , Dankos Laboratories ( DNKS ) , Enseval Son Megatrading ( EPMS ) – as well as forming a company that truly integrated . Horizontally , Kalbe ” new ” offer a product range that is much wider , ranging from various forms of drug and health food supplements and energy drinks through . Vertically, they perform activities from procurement of raw materials , finished product manufacturing , marketing , to sales and distribution.
Consolidation is done , Kalbe officials and analysts predict , will improve the efficiency of business operations . For any procurement , centralized management will make bargaining power increases so that the purchase price of raw materials can be reduced . Inventory will also be more efficient . Similarly , economies of scale production skyrocketed .
On the marketing side , the allocation of funds for the expansion of the market will swell to new markets that can be worked will also be much more extensive and , tail , improve competitiveness . Marketing efforts are cleverly divided by the market from various sides – OTC ( over-the- counter drugs that can be sold freely , without a doctor’s prescription ) , ethical ( prescription drugs ) , hospitals , physician practices , medical specialists , institutions – can be done more focused .
“If the company is not large , do this responsibility , ” said Herman Widjaja . The reason , according to the Kalbe Group Marketing Director , for maintaining that particular row salespeople were required considerable additional cost .
Beyond the issue of efficiency , the merger is done to stop the ” civil war ” that has been happening . Previously , people Kalbe and Dankos , for example , because it knows properly the contents of the stomach , respectively , in each field with fierce jegal . With the merger that made them into one team , aggressiveness on the field will certainly be transferred to outside competitors .
Remarkably , despite civil war , Kalbe and Dankos pramerger can share market area . In product categories flu medicine , for example , Kalbe Procold carrying flags fluttering in Indonesia Region West , from Central Java and Jakarta . Meanwhile , Mixagrip which bears the name of Dankos strong in eastern Indonesia , ranging from East Java to Bali , East Nusa Tenggara and Sulawesi . Not surprisingly , both of these brands so equally large and in the aggregate owns 40 % of the national market .
Separation of the market , according to Herman , was not formally designed . Nevertheless, he said , ” We , right , perform in a focused marketing activity so as not to overflow into all areas . So , the bags are formed . ” Reason behind this ? ” To be ( in marketing efforts ) do not run out of funds . ”
In terms of sales , Mixagrip become the market leader with a share of around 30 % so that even surpass Procold lost Ultraflu ( Henson pharma ) and Decolgen ( Medifarma ) .
However , mastering the higher market segments ( mass affluent and middle mass ) , Procold provide higher profit margins than Mixagrip the lower market segments (middle massdan lower mass ) .
The division of the target market segments like this is definitely not a coincidence . In 1974 , when Procold launched , the market for flu drugs lower-middle segment is very crowded . Therefore , Kalbe Procold then positioned on top of the local products that have mastered the lower segment through price competition , but still below the industry champion of foreign pharmaceutical products . For the market segment under greater – in 2005 , mass pasarlower size estimated at U.S. $ 900 million or much larger than the mass middle market ( U.S. $ 400 million ) , mass affluent ( U.S. $ 300 million ) or affluent ( U.S. $ 400 million ) – many years later Kalbe candidate Mixagrip produced Dankos .
Powered bold marketing efforts and painstaking , positioning the tandem paired proven to seize the market in all segments – from the bottom up . Although overall sales Procold ranks only 4th , for the upper – middle segment Kalbe flu drug product is still above Neozep and the like . Thus , in one category only products of this fat , Kalbe has created two major growth engine .
What do they do when conquering the market category of medicinal products arguably typical flu Kalbe . Established in 1966 , since the beginning Boenjamin Setiawan want to put Kalbe as the company that owns differentiation . When taking a pharmacology Ph.D. program at the University of California , Boenjamin who was then a young lecturer at the Faculty of Medicine, University of Indonesia sees growth opportunities not only pharmaceutical company that produces generic drugs in the country .
” Products are made to be unique , different from the existing ones in the market , ” said dr . Boen . ” And , the product must be marketed with a good strategy . ”
However , despite a clear vision , not easy to be a business to make it happen . The proof , initial efforts dr . Young Boen with some fellow lecturers FKUI failed .
In 1963 , a new two -year return of the United States , socio- economic condition of Indonesia may not have been too conducive to a business with great ideals . Or maybe , he and his friends are fellow physicians experienced no run business so chaotic results.
Fortunately , Boen not despair though was tempted offer big paying job in the Netherlands . Together with five siblings who have a variety of scientific backgrounds – some are doctors , dentists , pharmacists and economics graduate – he tried again .
This time , after initially rented a garage in the area of ​​Tanjung Priok , 6 brothers issued capital each big enough . ” Kamicommitted because then bought the building in Tanjung Priok so no way back , ” said born in Tegal , 23 September 1933 , with a laugh . “If not , we will lose . ”
Commitments made ​​at the right time , we know , successful childbirth .
In 1966 , with the rise of Suharto as President who opened the door wide for the entry of foreign capital , ranks multinationals flocked to Indonesia . Pfizer , GSK and Boehringer not only bring capital but also technology . ” And the most important technologies that they bring , ” said dr . Boen earnestly , ” is … marketing . ”
Boen remember very well , when it was a local company such as Incense and Soho only produce generic drugs are sold at low prices .
 Meanwhile , the champion of the world pharmaceutical industry to sell its products at high prices due to the marketing efforts are not cheap .
Given this reality , he said , ” We went in with a price in the middle position . ”
Positioning at the top but the generic product under the originator ‘s product makes Kalbe can reap enough profit margins fat and still have a price advantage that allows to compete with multinational corporations .
Create boost brand created , Boen also not rely solely on marketing .
From the beginning , he incorporates elements of research and development into products Kalbe . By replacing or adding 1-2 active ingredients of the original composition of the product , he can differentiate the product . Moreover , the scientific background as a physician pharmacologists enabled him to create a rational composition .
Until now , the basic strategy is still adhered to by Kalbe . In terms of prices , for example , despite already having an extensive network of doctors , Kalbe still set prices ” at the top of a generic product , but under the product originator ” .
” On average they ( Kalbe ) set the price of the product 8 times the price of a generic drug and under the price of the originator product , ” said an executive of a national pharmaceutical company .
The director who refused to be named this call Kalmoxillin as an example . Kalbe artificial antibiotic product is priced about 8 times the price of Amoxicillin , at least before the generic product whose price is set by the government is downgraded , but still cheaper than Amoxil is an original product .
Perhaps you will ask , is there a national company that dared to set product prices , which in fact is just a cheat , higher than the original products of the pharmaceutical industry champions abroad ?
And he said no . And the product of this greedy pharmaceutical companies still find a buyer .
Understandably , the drugs we call it by the name ” S ” it is a prescription medication that is prescribed by doctors, anyone can not replace the Amoxicillin ( generic ) ,
Kalmoxillin ( branded generics are less expensive and may not necessarily be of poor quality ) , even Amoxil ( original brand ) , without the consent of the doctor who wrote the prescription .
Pharmaceutical companies are well-known greedy doctor is obviously a lot to buy quickly skyrocket . Therefore , given that the wood without messing Kalbe like it could be the biggest pharmaceutical companies , it raises its own admiration .
Another thing that is admirable , it was, courage Kalbe OTC product launches .
 Different from the ethical product purchasing decisions in the hands of a doctor , in order to be successful in the market , a drug that can be purchased without a prescription it must obtain the final consumer trust .
 Because it involves millions of his own pocket and population , the end consumer is obviously more difficult than the doctor who persuaded tens of thousands and the population is only just getting patients to buy ( and , of these transactions , he could get a big bonus ) . In addition , the price of OTC products also can not be set too high because the competition is much more free , so that the relatively low profit margins .
In short, build brand OTC products is much more difficult – takes longer and costs more – than prescription drugs . Take for example Fatigon .
Previously marketed as ethical products , multivitamins of Dankos was launched as an OTC in the mid -1990s . However , Arie Wibowo message through a new entrance into the minds of consumers in the early 2000s , so they were only able to enjoy the results in recent years .
To build OTC brands , the efforts made much longer than the existence of ad impressions that can be monitored through the television set . Long before the products are formulated , first conducted research for knowing the needs of the market . From these results – for example , some people will need medications to eliminate fatigue with a certain price range – the exact composition of the product created and developed the production process accordingly.
Products that respond to these needs, Fatigon , developed based formulations neurovitamin plus vitamin E.
 This combination is already on the market , the product has even made ​​me too it by a national pharmaceutical company .
Dankos innovation lies in the addition of potassium and magnesium salts of L – aspartate which can accelerate the dismantling of lactic acid .
 Well , because it can accelerate the dismantling of a substance which is a metabolic waste that causes muscle fatigue and communicated this Fatigon as a multivitamin to make fatigue go away ( gone ) , aka tired relievers . This ingenious Positioningyang make Fatigon able to capture 35 % market share multivitamin .
And they did not stop there . Create meremajakannya – or mengapitalisasi Fatigon name that has been built at a cost of tens of billions – Dankos develop another variant : Spirit Fatigon spiked with L- carnitine , an amino acid compound which can accelerate the burning of fat into energy .
Create distinguish it from ordinary Fatigon , product extensions which no longer contain L – aspartate salt is dressed in a bright red packaging and take Primus Yustisio as endorser .
Kalbe is good at developing brand and meremajakannya . View Promag alone . Launched in 1971 as the first stomach pain medications advertised , antacid ( neutralizing stomach acid ) this one is one of the few local products which is able to defeat the dominant products of multinational companies in almost all countries .
Bottles are Teh Bak conquer the Coca-Cola Soft Drinks Global King , Promag garnering 80 % market share of stomach pain medications , making Mylanta is popular all over the world it did not move . Ke-4/2005 quarter , according to a survey conducted by a third , with sales of Rp 33.13 billion Promag was ranked 5th best-selling drug in the ranks of drug stores .
Amazingly, Kalbe is not only able to maintain a relatively cheap Promag it . Later , they were also able to develop it into a more upper class with Promag Double Action . Then , to keep the attack from below , Kalbe use Toedjoe Star to confront the Chinese-yam which , again , has a product differentiation . Joint Chinese-yam which also controls the sale of greater than Mylanta , Kalbe holding 89 % market share of stomach pain medications .
In the category of other medicinal products , Kalbe also triumphed . Neo – Enterostop holding 48 % market share antidiarrheal medication . In kerubutan , Woods , Komix , Mixadin and controls 50 % market Mextril cough medicine . Then , as mentioned above , and Mixagrip Procold captured 40 % market share of the flu drug .
In fact , with sales of USD 8.92 billion , according to a survey conducted third party , Procold ” reformula ” which was launched in February 2004 was ranked top selling new medicines in drugstores for IV/2005 quarter , followed by Extra Joss B7 ( selling USD 6.11 billion ) which was launched in May 2005 . The new OTC products other Kalbe Group , Irex Max , which launched in July 2004 was ranked as the 7th with sales of USD 2.99 billion .
Kalbe successful launching of this OTC product range makes them hoist themselves as the most successful company sells its products through drug stores . IV/2005 quarter , the Group Kalbe reap sales of Rp 284.42 billion of free drug was the biggest outlets – leaving far its closest competitor , Pfizer Group and Tempo Group is in the same quarter each only grossed sales of Rp 177.30 billion and Rp 160.93 billion .
In the energy drink product category , with Extra Joss is holding 43 % market share , again Kalbe successful global brand memecundangi dominant everywhere . Currently , Extra Joss which is one of the biggest growth engine Kalbe has set foot in the Philippines market . In Indonesia , the products cleverly formulated in the form of effervescent powder has diekstensi so Extra Joss LG , Extra Joss Extra Joss X and Endurance .
In dairy products and other health foods , Kalbe also showed his power . Drawn Prenagen (which has over 68 % market share of dairy product categories for pregnant women ) and Diabetasol ( which is holding 51% market share clinical food product category ) as the biggest growth locomotive , in 2005 they reap sales of U.S. $ 104 million from health food – far over -the-counter as well as energy drinks , each of which only U.S. $ 88 million .
For products that can be bought , Kalbe occupy an honored place in every major category . In the category of OTC drug products , for example , with a market share of 12.7 % in 2005 Kalbe fluttering at the top , beat Tempo ( 10.4 % ) or Konimex ( 7.4 % ) were known to have a strong brand it .
In the category of energy drink products , Kalbe dominance almost impossible shaken . Extra Joss market share and its derivatives in 2005 reached 43.5 % which is much larger than the Red Bull ( 22.4 % ) and Hemaviton and its derivatives ( 12.5 % ) combined.
Only in the category of nutritional products Kalbe is holding a 10.1 % market share lost to specialist dairy products : Nestle ( 36.1 % ) and Sari Husada ( 14.4 % ) . Nevertheless, considering Kalbe mainly go into the premium market , profit margins are fatter certainly ditangguk
For ethical product category ? Kalbe still have to admit supernatural Dexa Medica and Pharma were indeed whiz Sanbe ethical products . However , control of the national market share of 9.4 % , in the categories of products should only be sold with a doctor ‘s prescription Kalbe who was ranked 3rd narrowly lost Dexa ( 12.0 % ) and Sanbe ( 10.3 % ) .
Kalbe income of ethical product category is mostly obtained through the sale of branded drug products ( 60.0 % , valued at U.S. $ 83 million ) , followed by products licensed drugs ( 29.0 % , valued at U.S. $ 41 million ) , which gives a relatively high margin . Product sales are low-margin generic drugs accounted for only 11.0 % ( worth U.S. $ 15 million ) .
If dissected according to the target market , revenue Kalbe of ethical product categories derived primarily from sales through specialist physicians ( 46 % ) , followed by general practitioners ( 21 % ) and institute ( 13 % ) . Of this target market , again the composition of high -margin sales of ethical products is very dominant . Specialists, we know , always prescribe the most expensive drugs . Meanwhile , sales to institutions normally associated with generic drugs . For non-branded drugs , market institutions provide higher profit margins than regular market in the era of regional autonomy is highly fragmented , so the high cost of marketing .
Kalbe success marketing products with high margins also reflected on their key products are relatively brand new . Subcategory of antibiotic products carrying names Cefspan , Fixef , Cravit , Reskuin , Tarivid , Danofloc , Cefizox and Cefazol . Then , no more than a subcategory produkhospital ( Fimalbumin and Octalbin ) , antineoplastic and immunomodulatory ( Paxus , epirubicin ) , musculo – skeletal system ( Mediflex ) .
Ke-4/2005 quarter , Cefspan even ranked 7th best-selling drug list with sales of Rp 19.14 billion, growing 26 % from the previous year to Rp 15.22 billion and was ranked 15th . For new drug products in pharmacies , managed to put Mediflex Kalbe ranked 8th best sellers with sales of USD 3.20 billion and Doxorubicin at No. 11 (USD 2.59 billion ) . Meanwhile , for new pharmaceutical products in hospitals , they managed to put Cernevit ( sales of USD 3.21 billion ) billion at No. 4 , followed by doxorubicin (USD 2.20 billion ) at No. 9 , epirubicin ( USD 2 billion ) at No. 12 , Fima Hes 200 ( USD 1.86 billion ) at No. 16 , and Kalbamin (USD 1.83 billion ) in the rankings to 18th .
The number of new products whose sales shot shows that Kalbe has a lot of future growth engines . ” We will regularly launches 15 new products every year , ” said Johannes Setijono , CEO of Kalbe , sure .
If the products are launched it as they had done before – at least in part based biotechnology which , because of the high – tech , very few competitors – the engine of future growth Kalbe will certainly extraordinary .
 Moreover , if the grand plan went into biogenerik products through Innogene materialize .
Understandably , in the whole world will be confirmed only a handful of pharmaceutical companies are able to produce generic biotechnology-based products that complicated .
Beyond this , in collaboration with Recombio , Innogene even develop a vaccine for cancer called 1E10 .
With anti – idiotypic cancer vaccine made ​​from mammalian cells needed this particular , breast cancer , lung cancer and skin cancer will have an effective alternative to drugs and 40 % less expensive . Another big leap pursued Kalbe Group is the product of a stem cell biotechnology .
Other growth engine , which is no less great , is selling to overseas markets . In 2005 , the export value of their drug products that Rp 294.83 billion – plus packaging (USD 7.26 billion ) and health foods ( USD 8.76 billion ) – a new portion occupies 5.2 % of the total sales . That is , the export market segments still gives a very spacious room to grow .
In 2005 , with the Orange holding Drug Ltd. . , Nigeria , Kalbe establish a joint venture . With Orange – Kalbe operation in 2007 , sales are expected Promag , Procold , Neo – Enterostop , and other Kalbe mainstay products in the West African country will exceed U.S. $ 10 million / year . For the 30 % ownership stake , Kalbe plant U.S. $ 3 million .
” But , all the equipment we send from here , anyway, ” said dr . Boen sumringah Tegalnya subtle accent . Elderly men who still energetic hope , in the next five years , exports soared Kalbe will contribute 15 % to total sales .
Joint venture with Morinaga , Kalbe which controls 70.0 % of shares is also building dairies . This step will obviously strengthen their position in the dairy business premium class . Currently, Chil Mil and its derivatives have defeated foreign premium brands in other countries generally dominate the market .
Beyond that , Kalbe presumably could also hope to develop Enseval Son Megatrading be considerable growth engine . Has 40 distribution centers that are directly or indirectly mengover 1 million outlets , trunk distribution Kalbe is the largest distributor of healthcare products in Indonesia . In 2005 , 25 % Enseval reap revenue from Eisei , Takeda , L’ Oreal , Mead Johnson and other international business partners .
With the increasing number of foreign products coming into the country , experienced Enseval poduk distributes various categories – from OTC , prescription drugs , chemicals and other raw materials to consumer products healthdan health equipment – will certainly get a chance to enlarge his business . Understandably , however , new entrants from outside is not possible to handle its own distribution elaborate .
In addition , although lagging step of Dexa , Kalbe is also developing a test lab bioavailability / bioekivalen ( BA / BE ) . Under harmonization of ASEAN market in 2008 , which requires all drugs to be distributed in Southeast Asian markets tested BA / BE , Pharma Labs built Metrics is certainly a great opportunity to become a profit center .
All of this makes Kalbe one of the few Indonesian business entities that are well- positioned in the AFTA era soon . Moreover , if the consolidation is done running smoothly . Opportunities to it ? They are quite certain, that a grand merger will be done as smoothly as planned . The reason is simple , it just happened in the merger between the parent companies who are committed to one , with the same purpose . All subsidiaries are taken each parent only needs to submit to the commitment of its parent .
For example , Star Toedjoe previously under Dankos , stay involved just what the commitment Dankos . Even if there is displacement position , said officials Kalbe , ” That was ordinary . We have often experienced the rotation . ”
In metamorphosis Kalbe , what is done now to 2015 is a big stage of globalization . To that end , the expansion should be done at least to the ASEAN region . Here , because of his elephant -sized , large -sized businesses is a must . That is why , the merger is done . After the completion of internal consolidation , mergers and acquisitions will be done externally in order to stimulate growth .

Previously , the first metamorphosis ( 1966-94 ) , Kalbe been expanding rapidly in a similar way . In 1975 , for example , Kalbe establish subsidiaries outside its core business – but still related , ie Igar Jaya engaged in the packaging industry . This expansion was followed by the formation Dankos intended to enter the market further down .
Then , in 1981 , when the government requires a separate distribution business of production , Kalbe Enseval release . That same year , Kalbe parenteral preparations go into business and consumer health business venturing , each through Finusol Prima Perkasa and Biosciences .
In 1985 , Kalbe first major acquisition . Using Dankos hand , they annexed Toedjoe Star and Hexpharm . Then , in 1989 , as an exploratory step into the capital market , stock Dankos and Igar Jaya launched on the JSE and the Surabaya Stock Exchange . After that go public TEBUKTI it profitable , then the main company , Kalbe Farma , brought to the trading floor .
With stronger capital , 1993 , Kalbe Farma first consolidation : Mighty Biosciences annexed and put bisnisconsumer health subsidiary to this one . That same year , went into business Kalbe energy drinks . In 1994 , the stock turn Enseval released to the trading floor . The era of expansion led new business development and acquisition closed with the establishment of PT Bifarma Adiluhung and the launch of Extra Joss by Toedjoe Star in 1995 .
Entering 1996, the major consolidation Kalbe start by removing 50 % stake Hill manikam Sakti engaged in the food business to Arnotts . More comprehensive consolidation carried out in 1997 and thereafter when Kalbe worse by the financial crisis that hit Asia .
The fast pace back to the core business – consumer health , ethical pharmaceutical products , as well as distribution and packaging – Kalbe saved from the brink of bankruptcy . In 2005 , consumer healthyang include OTC pharmaceutical products , product nutisi and energy drinks accounted for 47 % of revenue. The rest , contributed ethical pharmaceutical products ( 23 % ) as well as distribution and packaging ( 30 % ) . A balanced portfolio is one of the pillars of strength Kalbe .
Another pillar of strength , we have referred to above , is their prowess in research & development as well as the skill and perseverance to market products , especially OTC , which they developed . Still less ?
Yes , there is one more pillar of the biggest : human resources and management professionals . Different from Lippo Ciputra Group or its management or the Salim family dikangkangi still strong , Kalbe arguably the only large conglomerates are almost fully staffed professional management .
Realizing its strength as a scientist and visionary but less control of the management of everyday business – perhaps the wisdom of two times the initial failure – dr . Boen since the beginning of setting up the management ranks of professionals to manage Kalbe . When in this country not many qualified executives , he did not hesitate to pay expensive expatriates .
Currently , management Kalbe has arguably matured . In terms of lessons learned , they may be more complete than any big company management in the country . And they managed to rise from adversity to remain the largest .
” The blow was severe , if not deadly , it will make us stronger , ” said the wise man . This power alone , plus the advantages of being a public company whose majority shares are still controlled by the family – must be transparent , but strong enough to resist the urge to minority investors are usually more concerned with short-term gains – likely to be a sufficient provision for Kalbe become big companies , even the grandest in the ASEAN region

Kamis, 01 Juni 2006
Oleh : Prih Sarnianto

Melalui merger, Kalbe Farma menyeruak ke posisi puncak jajaran perusahaan farmasi terakbarIndonesia. Apa saja kekuatan yang memungkinkan mereka jadi yang terbesar di kawasan ASEAN?

Inilah perkawinan terakbar di panggung bisnis Indonesia. Melalui merger internal itu, PT Kalbe Farma Tbk. sebagai surviving company menyalip Sanbe Farma yang selama bertahun-tahun berkibar di puncak sebagai perusahaan farmasi terbesar di Tanah Air.

Bahkan, lebih dari itu. Dengan kapitalisasi pasar US$ 2 miliar, perusahaan yang sahamnya tercatat di Bursa Efek Jakarta dengan kode KLBF ini juga memantapkan diri di peringkat teratas jajaran perusahaan publik di Asia Tenggara.

Dari segi penjualan, Kalbe hasil merger yang meraup revenueUS$ 267,2 juta, di kawasan Asia Tenggara hanya kalah dari Pfizer dan GlaxoSmithKline (GSK) yang memang raksasa industri farmasi dunia.

Kendati demikian, sebagai kelompok bisnis farmasi, Grup Kalbe sebenarnya selalu yang terbesar.

Maklum, di bawah payung kerajaan bisnis yang satu ini, secara langsung maupun tak langsung terdapat nama-nama besar, termasuk Bintang Toedjoe (produsen Extra Joss yang masuk jajaran 10 Besar Perusahaan Farmasi di Indonesia), Hexpharm (produsen obat generik terbesar ke-5 di Indonesia), Saka Farma (ingat Sakatonic ABC?), Sanghiang Perkasa (produsen Prenagen, Diabetasol, dan makanan kesehatan lainnya), Kalbe Morinaga (produsen susu terkemuka), Innogene Kalbiotech (produsen obat berbasis bioteknologi di Singapura) dan Kageo Igar Jaya (pengemas).

Merger yang melibatkan PT Enseval sebagaisuperholding dan tiga anak perusahaan yang terdaftar di BEJ tersebut  – Kalbe Farma, Dankos Laboratories (DNKS), Enseval Putera Megatrading (EPMS) — sekaligus membentuk perusahaan yang betul-betul terintegrasi. Secara horisontal, Kalbe “baru” menawarkan rentang produk yang jauh lebih luas, mulai dari berbagai bentuk obat dan makanan kesehatan sampai suplemen dan minuman berenergi. Secara vertikal, mereka melakukan kegiatan dari pengadaan bahan baku, manufakturing produk jadi, pemasaran, sampai penjualan dan distribusi.

Konsolidasi yang dilakukan, para petinggi Kalbe maupun analis meramalkan, bakal meningkatkan efisiensi operasional bisnis. Untuk pengadaan saja, penanganan yang terpusat akan membuat posisi tawar meningkat sehingga harga beli bahan baku dapat ditekan. Inventori juga bakal lebih efisien. Demikian pula, produksi yang skala ekonominya melejit.

Di sisi pemasaran, alokasi dana untuk perluasan pasar akan menggelembung sehingga pasar baru yang bisa digarap juga akan jauh lebih luas dan, buntutnya, meningkatkan daya saing. Upaya pemasaran yang dengan cerdik dibagi berdasarkan pasar dari berbagai sisi — OTC (over the counter, obat yang dapat dijual bebas, tanpa resep dokter), etikal (obat dengan resep), rumah sakit, dokter praktik, dokter spesialis, institusi — dapat dilakukan secara lebih fokus.

“Kalau perusahaannya tidak besar, melakukan ini tanggung,” ujar Herman Widjaja. Pasalnya, menurut Direktur Pemasaran Grup Kalbe ini, buat memelihara barisan tenaga penjualan yang khusus itu diperlukan biaya tambahan yang besar.

Di luar masalah efisiensi, merger yang dilakukan menghentikan “perang saudara” yang selama ini terjadi. Sebelumnya, orang-orang Kalbe dan Dankos, misalnya, karena tahu benar isi perut masing-masing, di lapangan saling jegal dengan sengit. Dengan penggabungan yang membuat mereka jadi satu tim, agresivitas di lapangan tentunya akan dapat dialihkan ke pesaing luar.

Hebatnya, walau terjadi perang saudara, Kalbe dan Dankos pramerger dapat berbagi wilayah pasar. Di kategori produk obat flu, misalnya, Procold yang membawa bendera Kalbe berkibar di Kawasan Indonesia Barat, mulai dari Jawa Tengah dan Jakarta. Sementara itu, Mixagrip yang menyandang nama Dankos kuat di Kawasan Indonesia Timur, mulai dari Jawa Timur sampai Bali, Nusa Tenggara Timur dan Sulawesi. Tak mengherankan, kedua merek ini jadi sama-sama besar dan secara agregat menguasai 40% pasar nasional.

Pemisahan pasar tersebut, menurut Herman, secara resmi tidak dirancang. Kendati demikian, katanya, “Kami, kan, melakukan marketing activity secara terfokus agar tidak meluber ke semua wilayah. Jadi, dibentuklah kantong-kantong tersebut.” Alasan di balik ini? “Agar (dalam upaya pemasaran) tidak kehabisan dana.”

Dari sisi penjualan, Mixagrip menjadi pemimpin pasar dengan pangsa sekitar 30% sehingga mengungguli Procold yang bahkan kalah dari Ultraflu (Henson farma) dan Decolgen (Medifarma).

Namun, menguasai segmen pasar yang lebih tinggi (mass affluent dan middle mass), Procold memberikan margin laba yang lebih tinggi ketimbang Mixagrip yang segmen pasarnya lebih rendah (middle massdan lower mass).

Pembagian target segmen pasar seperti ini jelas bukan merupakan kebetulan. Pada 1974, ketika Procold diluncurkan, pasar obat flu untuk segmen menengah-bawah sudah sangat sesak. Sebab itu, Kalbe lalu memosisikan Procold di atas produk lokal yang telah menguasai segmen bawah melalui persaingan harga, tetapi masih di bawah produk kampiun industri farmasi asing. Untuk segmen pasar bawah yang lebih besar — pada 2005, size pasarlower mass diperkirakan US$ 900 juta atau jauh lebih besar ketimbang pasar middle mass (US$ 400 juta), mass affluent (US$ 300 juta) ataupun affluent(US$ 400 juta) — bertahun-tahun kemudian Kalbe menjagokan Mixagrip yang diproduksi Dankos.

Didukung upaya pemasaran yang berani dan telaten,positioning yang dipasangkan secara tandem tersebut terbukti ampuh untuk merebut pasar di seluruh segmen — dari yang bawah sampai ke atas. Walau secara keseluruhan penjualan Procold hanya menduduki peringkat ke-4, untuk segmen menengah-atas produk obat flu Kalbe ini masih di atas Neozep dan sebangsanya. Dengan demikian, di satu kategori produk yang gemuk ini saja, Kalbe berhasil menciptakan dua mesin pertumbuhan yang besar.

Apa yang mereka lakukan ketika menaklukkan pasar kategori produk obat flu boleh dibilang khas Kalbe. Didirikan pada 1966, sejak awal Boenjamin Setiawan ingin menempatkan Kalbe sebagai perusahaan yang memiliki diferensiasi. Ketika mengambil program Ph.D bidang farmakologi di University of California, Boenjamin yang kala itu menjadi dosen muda di Fakultas Kedokteran Universitas Indonesia melihat peluang tumbuhnya perusahaan farmasi yang tak hanya memproduksi obat generik di Tanah Air.

“Produk yang dibuat haruslah unik, berbeda dari yang sudah ada di pasar,” tutur dr. Boen. “Dan, produk itu harus dipasarkan dengan strategi yang baik.”

Namun, walau visinya jelas, tak gampang mewujudkannya jadi sebuah bisnis. Buktinya, upaya awal yang dilakukan dr. Boen muda bersama beberapa rekan dosen FKUI gagal.

Pada 1963 itu, baru dua tahun pulang dari Amerika Serikat, kondisi sosial-ekonomi Indonesia mungkin belum kelewat kondusif untuk sebuah bisnis dengan cita-cita besar. Atau mungkin, dia dan kawan-kawan yang sesama dokter tak ada yang berpengalaman menjalankan bisnis sehingga amburadul hasilnya.

Untungnya, Boen tak putus asa walau sempat tergiur tawaran kerja bergaji gede di Belanda. Bersama lima saudaranya yang memiliki berbagai latar belakang keilmuan — ada yang dokter, dokter gigi, apoteker dan sarjana ekonomi — dia mencoba lagi.

Kali ini, setelah awalnya menyewa garasi di kawasan Tanjung Priok, 6 bersaudara itu masing-masing mengeluarkan modal cukup besar. “Kamicommitted lantaran lalu beli gedung di Tanjung Priok sehingga tak bisa mundur lagi,” tutur kelahiran Tegal, 23 September 1933, itu sambil tertawa. “Kalau tidak, kami akan rugi.”

Komitmen yang dilakukan pada saat yang tepat tersebut, kita tahu, melahirkan sukses.

Pada 1966 itu, dengan naiknya Soeharto sebagai Presiden RI yang membuka pintu lebar-lebar bagi masuknya modal asing, barisan perusahaan multinasional berbondong ke Indonesia. Pfizer, GSK dan Boehringer bukan hanya membawa modal, melainkan juga teknologi. “Dan teknologi terpenting yang mereka bawa,” ungkap dr. Boen dengan sungguh-sungguh, “adalah … marketing.”

Boen ingat betul, waktu itu perusahaan lokal seperti Dupa dan Soho hanya memproduksi obat generik yang dijual dengan harga murah.

Sementara itu, para jawara industri farmasi dunia menjual produknya dengan harga mahal karena melakukan upaya pemasaran yang tidak murah.

Melihat kenyataan ini, tuturnya, “Kami masuk dengan posisi harga di tengah.”

Positioning di atas produk generik tetapi di bawah produk originator ini membuat Kalbe dapat menangguk margin laba cukup gemuk dan tetap memiliki keunggulan harga yang memungkinkan bersaing dengan kalangan perusahaan multinasional.

Buat mendongkrak merek yang diciptakan, Boen juga tak hanya mengandalkan pemasaran.

Sejak awal, dia memasukkan unsur riset & pengembangan ke dalam produk-produk Kalbe. Dengan mengganti atau menambah 1-2 bahan aktif dari komposisi produk original, dia dapat mendiferensiasi produk. Apalagi, latar belakang keilmuannya sebagai dokter yang ahli farmakologi memungkinkannya menciptakan komposisi yang rasional.

Sampai saat ini, strategi dasar ini masih dipegang teguh oleh Kalbe. Dari sisi harga, misalnya, walau telah memiliki jaringan dokter yang luas, Kalbe tetap menetapkan harga yang “di atas produk generik, tetapi di bawah produk originator”.

“Rata-rata mereka (Kalbe) menetapkan harga produknya 8 kali harga obat generik dan di bawah harga produk originator,” ujar seorang eksekutif perusahaan farmasi nasional.

Sang direktur yang tak mau disebut namanya ini menyebut Kalmoxillin sebagai contoh. Produk antibiotik buatan Kalbe ini dibanderol sekitar 8 kali harga Amoxicillin, setidaknya sebelum produk generik yang harganya ditetapkan pemerintah ini diturunkan, tetapi masih lebih murah ketimbang Amoxil yang merupakan produk original.

Mungkin Anda akan bertanya, adakah perusahaan nasional yang berani menetapkan harga produknya, yang notabene cuma contekan, lebih tinggi ketimbang produk original dari kampiun industri farmasi mancanegara?

Jawabnya: ada. Dan produk perusahaan farmasi yang serakah ini tetap mendapatkan pembeli.

Maklum, obat yang kita sebut saja dengan nama “S” itu adalah obat etikal yang diresepkan dokter, siapa pun tak boleh mengganti dengan Amoxicillin (generik),

Kalmoxillin (generik bermerek yang lebih murah dan belum tentu lebih jelek kualitasnya), bahkan Amoxil (merek original), tanpa persetujuan dokter yang menulis resep tersebut.

Perusahaan farmasi serakah yang terkenal banyak membeli dokter ini jelas cepat meroket. Karena itu, menilik bahwa Kalbe tanpa main kayu seperti itu bisa jadi perusahaan farmasi terbesar, sungguh menimbulkan kekaguman tersendiri.

Hal lain yang patut diacungi jempol adalah, itu tadi, keberanian Kalbe meluncurkan produk OTC.

Berbeda dari produk etikal yang keputusan belinya ada di tangan dokter, agar sukses di pasar, obat yang dapat dibeli tanpa resep itu harus memperoleh kepercayaan konsumen akhir.

Karena menyangkut kocek sendiri dan populasinya jutaan, konsumen akhir jelas lebih sulit dibujuk ketimbang dokter yang populasinya hanya puluhan ribu dan sekadar menyuruh pasien untuk beli (lalu, dari transaksi tersebut, dia bisa mendapat bonus gede). Selain itu, harga produk OTC juga tak dapat ditetapkan kelewat tinggi karena persaingannya jauh lebih bebas, sehingga margin labanya relatif rendah.

Pendek kata, membangun merek produk OTC jauh lebih sulit — makan waktu lebih lama dan biaya lebih banyak — ketimbang obat etikal. Ambil contoh Fatigon.

Sebelumnya dipasarkan sebagai produk etikal, multivitamin dari Dankos ini diluncurkan sebagai OTC pada pertengahan 1990-an. Namun, pesan melalui Arie Wibowo baru masuk ke benak konsumen pada awal 2000-an, sehingga mereka baru bisa menikmati hasilnya beberapa tahun belakangan.

Untuk membangun merek OTC, upaya yang dilakukan jauh lebih panjang ketimbang adanya tayangan iklan yang bisa dipantau melalui pesawat televisi. Jauh sebelum produk diformulasikan, dilakukan dulu penelitian buat mengetahui kebutuhan pasar. Dari hasil penelitian ini — misalnya, kebutuhan sebagian masyarakat akan obat yang dapat menghilangkan kelelahan dengan kisaran harga tertentu — diciptakan komposisi produk yang tepat dan dikembangkan proses produksi yang sesuai.

Produk yang menjawab kebutuhan ini, Fatigon, dikembangkan berdasarkan formulasi neurovitamin plus vitamin E.

Kombinasi ini sudah ada di pasar, bahkan sudah dibuat produk me too-nya oleh sebuah perusahaan farmasi nasional.

Inovasi Dankos terletak pada penambahan garam kalium dan magnesium dari L-aspartat yang dapat mempercepat pembongkaran asam laktat.

Nah, karena bisa mempercepat pembongkaran zat yang merupakan sisa metabolisme yang menimbulkan lelah otot inilah Fatigon lalu dikomunikasikan sebagai multivitamin untuk membuat fatigue pergi (gone), alias obat penghilang lelah. Positioningyang cerdik ini membuat Fatigon mampu merebut 35% pangsa pasar multivitamin.

Dan mereka tak berhenti sampai di situ. Buat meremajakannya — atau mengapitalisasi nama Fatigon yang telah dibangun dengan biaya puluhan miliaran — Dankos mengembangkan varian lain: Fatigon Spirit yang dibubuhi L-carnitin, senyawa asam amino yang dapat mempercepat pembakaran lemak menjadi energi.

Buat membedakannya dari Fatigon biasa, produk ekstensi yang tak lagi mengandung garam L-aspartat ini didandani dengan kemasan merah menyala dan mengambil Primus Yustisio sebagai endorser.

Kalbe memang piawai mengembangkan merek dan meremajakannya. Lihat saja Promag. Diluncurkan pada 1971 sebagai obat nyeri lambung pertama yang diiklankan, antasida (penetral asam lambung) yang satu ini adalah satu dari sedikit produk lokal yang mampu mengalahkan produk perusahaan multinasional yang dominan di hampir semua negara.

Bak Teh Botol yang menaklukkan Coca-Cola sang Raja Minuman Ringan Global, Promag meraup 80% pangsa pasar obat nyeri lambung, membuat Mylanta yang ngetop di seluruh penjuru dunia itu tak berkutik. Pada kuartal ke-4/2005, menurut survei yang dilakukan pihak ketiga, dengan penjualan Rp 33,13 miliar Promag menduduki peringkat ke-5 jajaran obat terlaris di toko-toko obat.

Hebatnya lagi, Kalbe bukan cuma mampu mempertahankan Promag yang harganya relatif murah itu. Belakangan, mereka juga mampu mengembangkannya ke kelas yang lebih atas dengan Promag Double Action. Lalu, untuk menjaga serangan dari bawah, Kalbe menggunakan Bintang Toedjoe untuk menghadang dengan Waisan yang, lagi-lagi, memiliki diferensiasi produk. Bersama Waisan yang juga menguasai penjualan lebih besar ketimbang Mylanta, Kalbe menggenggam 89% pangsa pasar obat nyeri lambung.

Di kategori produk obat lainnya, Kalbe juga berjaya. Neo-Enterostop menggenggam 48% pangsa pasar obat antidiare. Secara kerubutan, Woods, Komix, Mixadin dan Mextril menguasai 50% pasar obat batuk. Lalu, seperti yang telah disebutkan di atas, Procold dan Mixagrip merebut 40% pangsa pasar obat flu.

Bahkan, dengan penjualan Rp 8,92 miliar, menurut survei yang dilakukan pihak ketiga, Procold “reformula” yang diluncurkan pada Februari 2004 menduduki peringkat puncak obat-obat baru terlaris di toko obat untuk kuartal IV/2005, disusul Extra Joss B7 (penjualan Rp 6,11miliar) yang diluncurkan pada Mei 2005. Produk OTC baru Grup Kalbe lainnya, Irex Max, yang diluncurkan pada Juli 2004 menempati peringkat ke-7 dengan penjualan Rp 2,99 miliar.

Sukses Kalbe meluncurkan berbagai produk OTC ini membuat mereka mengibarkan diri sebagai perusahaan yang paling sukses menjual produknya melalui toko obat. Pada kuartal IV/2005, Grup Kalbe meraup penjualan Rp 284,42 miliar dari gerai terbesar obat bebas itu — meninggalkan jauh pesaing terdekatnya, Grup Pfizer dan Grup Tempo yang pada kuartal yang sama masing-masing hanya meraup penjualan Rp 177,30 miliar dan Rp 160,93 miliar.

Di kategori produk minuman berenergi, dengan Extra Joss yang menggenggam 43% pangsa pasar, lagi-lagi Kalbe berhasil memecundangi merek global yang dominan di mana-mana. Saat ini, Extra Joss yang merupakan salah satu motor pertumbuhan terbesar Kalbe telah menancapkan kaki di pasar Filipina. Di Indonesia, produk yang dengan cerdik diformulasikan dalam bentuk serbuk effervescent ini telah diekstensi jadi Extra Joss LG, Extra Joss X dan Extra Joss Endurance.

Di produk susu dan makanan kesehatan lainnya, Kalbe juga menunjukkan kesaktiannya. Dihela Prenagen (yang menguasai 68% pangsa pasar kategori produk susu untuk ibu hamil) dan Diabetasol (yang menggenggam 51% lebih pangsa pasar kategori produk clinical food) sebagai lokomotif pertumbuhan terbesar, pada 2005 mereka menangguk penjualan US$ 104 juta dari makanan kesehatan — jauh di atas obat OTC maupun minuman berenergi yang masing-masing hanya US$ 88 juta.

Untuk produk-produk yang dapat dibeli bebas ini, Kalbe menduduki tempat terhormat di setiap kategori besar. Di kategori produk obat OTC, misalnya, dengan pangsa pasar 12,7% Kalbe pada 2005 berkibar di puncak, mengalahkan Tempo (10,4%) ataupun Konimex (7,4%) yang dikenal memiliki banyak merek kuat itu.

Di kategori produk minuman berenergi, dominasi Kalbe bahkan hampir mustahil digoyahkan. Pangsa pasar Extra Joss dan turunannya pada 2005 yang mencapai 43,5% jauh lebih besar ketimbang Kratingdaeng (22,4%) dan Hemaviton beserta turunannya (12,5%) digabung jadi satu.

Hanya di kategori produk nutrisi Kalbe yang menggenggam 10,1% pangsa pasar kalah dari spesialis produk susu: Nestle (36,1%) dan Sari Husada (14,4%). Kendati demikian, mengingat Kalbe terutama masuk ke pasar premium, margin laba yang ditangguk tentu lebih gemuk

Untuk kategori produk etikal? Kalbe masih harus mengakui kesaktian Dexa Medica dan Sanbe Farma yang memang jagoan produk etikal. Akan tetapi, menguasai 9,4% pangsa pasar nasional, di kategori produk yang hanya boleh dijual dengan resep dokter ini Kalbe yang menduduki peringkat ke-3 kalah tipis dari Dexa (12,0%) dan Sanbe (10,3%).

Pendapatan Kalbe dari kategori produk etikal ini sebagian besar diperoleh melalui penjualan produk obat bermerek (60,0%, senilai US$ 83 juta), disusul produk obat lisensi (29,0%, senilai US$ 41 juta), yang memberikan margin relatif tinggi. Penjualan produk obat generik yang bermargin rendah hanya menyumbang 11,0% (senilai US$ 15 juta).

Jika dibedah menurut target pasar, pendapatan Kalbe dari kategori produk etikal terutama diperoleh dari penjualan melalui dokter spesialis (46%), disusul dokter umum (21%) dan insititusi (13%). Dari target pasar ini, lagi-lagi komposisi penjualan produk etikal bermargin tinggi sangat dominan. Dokter spesialis, kita tahu, selalu memberikan resep obat-obat yang termahal. Sementara itu, penjualan ke institusi biasanya terkait dengan obat generik. Untuk obat tanpa merek, pasar institusi memberikan margin laba yang lebih tinggi ketimbang pasar reguler yang di era otonomi daerah ini sangat terfragmentasi, sehingga biaya pemasarannya tinggi.

Keberhasilan Kalbe memasarkan produk dengan margin tinggi juga tecermin pada produk kunci mereka yang relatif gres. Dari subkategori produk antibiotik tercatat nama-nama Cefspan, Fixef, Cravit, Reskuin, Tarivid, Danofloc, Cefizox dan Cefazol. Lalu, ada lagi dari subkategori produkhospital (Fimalbumin dan Octalbin), antineoplastik dan imunomodulator (Paxus, Epirubicin), musculo-skeletal system (Mediflex).

Pada kuartal ke-4/2005, Cefspan bahkan menduduki peringkat ke-7 daftar obat terlaris dengan penjualan Rp 19,14 miliar atau tumbuh 26% dari tahun sebelumnya yang hanya Rp 15,22 miliar dan menduduki peringkat ke-15. Untuk produk obat baru di apotek, Kalbe berhasil menempatkan Mediflex di peringkat ke-8 terlaris dengan penjualan Rp 3,20 miliar dan Doxorubicin di peringkat ke-11 (Rp 2,59 miliar). Sementara itu, untuk produk obat baru di rumah sakit, mereka berhasil menempatkan Cernevit (penjualan Rp 3,21 miliar) miliar di urutan ke-4, disusul Doxorubicin (Rp 2,20 miliar) di peringkat ke-9, Epirubicin (Rp 2 miliar) di peringkat ke-12, Fima Hes 200 (Rp 1,86 miliar) di peringkat ke-16, dan Kalbamin (Rp 1,83 miliar) di peringkat ke-18.

Banyaknya produk baru yang penjualannya melesat ini menunjukkan bahwa Kalbe memiliki banyak mesin pertumbuhan masa depan. “Kami akan rutin meluncurkan 15 produk baru setiap tahun,” ujar Johannes Setijono, CEO Kalbe, yakin.

Jika produk-produk yang diluncurkan tersebut seperti yang sudah-sudah — paling tidak sebagiannya berbasis bioteknologi yang, karena high-tech, sangat sedikit pesaingnya — mesin pertumbuhan masa depan Kalbe tentu akan luar biasa.

Apalagi, jika rencana besar masuk ke produk biogenerik melalui Innogene terwujud.

Maklum, di seluruh dunia dipastikan hanya akan ada segelintir perusahaan farmasi yang mampu menghasilkan produk generik berbasis bioteknologi yang rumit itu.

Di luar ini, bekerja sama dengan Recombio, Innogene bahkan mengembangkan vaksin untuk kanker yang disebut 1E10.

Dengan anti-idiotypic cancer vaccine yang dibuat dari sel mamalia yang diperlukan khusus ini, penderita kanker payudara, kanker paru dan kanker kulit akan memiliki obat alternatif yang efektif dan 40% lebih murah. Lompatan besar lain yang diupayakan Grup Kalbe adalah produk bioteknologi dari stem cell.

Mesin pertumbuhan lainnya, yang tak kalah besar, adalah penjualan ke pasar mancanegara. Pada 2005, nilai ekspor produk obat mereka yang Rp 294,83 miliar — ditambah kemasan (Rp 7,26 miliar) dan makanan kesehatan (Rp 8,76 miliar) — baru menempati porsi 5,2% dari penjualan total. Artinya, segmen pasar ekspor masih memberikan ruang yang sangat luas untuk tumbuh.

Pada 2005, dengan menggandeng Orange Drug Ltd., Nigeria, Kalbe mendirikan perusahaan patungan. Dengan beroperasinya Orange-Kalbe pada 2007, diharapkan penjualan Promag, Procold, Neo-Enterostop, dan produk andalan Kalbe lainnya di negara Afrika Barat itu akan menembus US$ 10 juta/tahun. Untuk kepemilikan 30% saham, Kalbe menanam US$ 3 juta.

“Tapi, semua peralatan kami kirim dari sini, kok,” ujar dr. Boen sumringah dengan logat Tegalnya yang kentara. Lelaki sepuh yang masih energik ini berharap, dalam lima tahun ke depan, ekspor Kalbe akan melejit hingga menyumbang 15% penjualan total.

Berpatungan dengan Morinaga, Kalbe yang menguasai 70,0% saham juga sedang membangun pabrik susu. Langkah ini jelas akan memperkuat posisi mereka di bisnis persusuan kelas premium. Saat ini saja, Chil Mil dan turunannya telah mengalahkan merek-merek premium asing yang di negara lain umumnya mendominasi pasar.

Di luar itu, Kalbe agaknya juga bisa berharap mengembangkan Enseval Putera Megatrading menjadi mesin pertumbuhan yang cukup besar. Memiliki 40 pusat distribusi yang secara langsung maupun tak langsung mengover 1 juta gerai, belalai distribusi Kalbe ini adalah distributor produk kesehatan terbesar di Indonesia. Pada 2005, Enseval menangguk 25% pendapatannya dari Eisei, Takeda, L’Oreal, Mead Johnson dan mitra bisnis internasional lainnya.

Dengan semakin banyaknya produk mancanegara yang masuk ke Tanah Air, Enseval yang berpengalaman mendistribusikan berbagai kategori poduk — dari OTC, obat etikal, bahan kimia dan bahan baku lainnya sampai produk consumer healthdan peralatan kesehatan – tentu akan mendapat peluang memperbesar bisnisnya. Maklum, bagaimanapun, pendatang baru dari luar tak mungkin menangani sendiri distribusi yang rumit itu.

Selain itu, walau tertinggal selangkah dari Dexa, Kalbe juga sedang mengembangkan laboratorium uji bioavailabilitas/bioekivalen (BA/BE). Di bawah harmonisasi pasar ASEAN pada 2008 yang mewajibkan seluruh obat yang akan diedarkan di pasar Asia Tenggara lulus uji BA/BE, Pharma Metrics Labs yang dibangun ini tentu berpeluang besar menjadi profit center.

Semua ini menjadikan Kalbe satu dari sedikit entitas bisnis Indonesia yang well-positioned di era AFTA yang tak lama lagi. Terlebih, jika konsolidasi yang dilakukan berjalan mulus. Peluang untuk itu? Mereka yakin benar, merger akbar yang dilakukan akan semulus yang direncanakan. Alasannya sederhana, merger itu hanya terjadi di antara perusahaan induk yang berkomitmen menjadi satu, dengan tujuan sama. Seluruh anak perusahaan yang dibawa masing-masing induk hanya perlu tunduk pada komitmen induknya.

Sebagai contoh, Bintang Toedjoe yang sebelumnya di bawah Dankos, tinggal ikut saja apa yang menjadi komitmen Dankos. Kalaupun ada perpindahan posisi, ujar para petinggi Kalbe, “Itu sudah biasa. Kami sudah sering mengalami rotasi.”

Dalam metamorfosis Kalbe, apa yang dilakukan sekarang sampai 2015 adalah tahapan besar globalisasi. Untuk itu, harus dilakukan ekspansi setidaknya ke kawasan ASEAN. Di sini, karena lawannya berukuran gajah, ukuran bisnis yang besar merupakan keharusan. Itu sebabnya, merger dilakukan. Setelah konsolidasi internal rampung, akan dilakukan merger dan akuisisi eksternal guna memacu pertumbuhan.

 

Sebelumnya, pada metamorfosis pertama (1966-94), Kalbe pernah melakukan ekspansi cepat dengan cara serupa. Pada 1975, misalnya, Kalbe mendirikan anak perusahaan di luar bisnis inti — tetapi masih berhubungan, yaitu Igar Jaya yang bergerak di industri pengemasan. Ekspansi ini diikuti dengan pembentukan Dankos yang dimaksudkan untuk masuk ke pasar lebih bawah.

Lalu, 1981, ketika pemerintah mengharuskan bisnis distribusi terpisah dari produksi, Kalbe melepas Enseval. Tahun itu juga, Kalbe masuk ke bisnis sediaan parenteral dan merambah bisnis consumer health, masing-masing melalui Finusol Prima dan Sanghiang Perkasa.

Pada 1985, Kalbe melakukan akuisisi besar pertama. Menggunakan tangan Dankos, mereka mencaplok Bintang Toedjoe dan Hexpharm. Lalu, pada 1989, sebagai langkah penjajakan ke pasar modal, saham Dankos dan Igar Jaya diluncurkan di BEJ dan Bursa Efek Surabaya. Setelah tebukti bahwa go public itu menguntungkan, barulah perusahaan utama, Kalbe Farma, dibawa ke lantai bursa.

Dengan modal lebih kuat, 1993, Kalbe Farma melakukan konsolidasi pertama: mencaplok Sanghiang Perkasa dan menempatkan bisnisconsumer health ke anak perusahaan yang satu ini. Tahun itu juga, Kalbe masuk ke bisnis minuman berenergi. Pada 1994, giliran saham Enseval diluncurkan ke lantai bursa. Era ekspansi yang dimotori pengembangan bisnis baru dan akuisisi ditutup dengan pendirian PT Bifarma Adiluhung dan peluncuran Extra Joss oleh Bintang Toedjoe pada 1995.

Memasuki 1996, Kalbe memulai konsolidasi besar dengan melepas 50% saham Bukit Manikam Sakti yang bergerak di bisnis makanan ke Arnotts. Konsolidasi yang lebih komprehensif dilakukan pada 1997 dan sesudahnya ketika Kalbe terpuruk oleh krisis moneter yang melanda Asia.

Langkah cepat kembali ke bisnis inti – consumer health, produk farmasi etikal, serta distribusi dan pengemasan — berhasil menyelamatkan Kalbe dari jurang kebangkrutan. Pada 2005, consumer healthyang meliputi produk farmasi OTC, produk nutisi dan minuman berenergi menyumbang 47% pendapatan. Sisanya, disumbang produk farmasi etikal (23%) serta distribusi dan pengemasan (30%). Portofolio yang seimbang ini merupakan salah satu pilar kekuatan Kalbe.

Pilar kekuatan lain, yang telah kita sebut di atas, adalah kehebatan mereka dalam riset & pengembangan serta kepiawaian dan keuletan memasarkan produk, terutama OTC, yang mereka kembangkan. Masih kurang?

Ya, ada satu lagi pilar terbesar: sumber daya manusia dan manajemen yang profesional. Berbeda dari Grup Ciputra atau Lippo atau Salim yang manajemennya masih kuat dikangkangi keluarga, Kalbe boleh dibilang satu-satunya konglomerat besar yang hampir sepenuhnya dikelola manajemen profesional.

Menyadari kekuatannya sebagai seorang saintis dan visioner tetapi kurang menguasai pengelolaan bisnis sehari-hari — mungkin ini hikmah dari dua kali kegagalan awalnya — dr. Boen sejak awal menyiapkan barisan manajemen profesional untuk mengelola Kalbe. Ketika di negeri ini belum banyak eksekutif yang mumpuni, dia bahkan tak segan membayar mahal ekspatriat.

Saat ini, manajemen Kalbe boleh dibilang telah matang. Dari segi pelajaran yang diambil, mereka mungkin lebih komplet ketimbang manajemen perusahaan besar mana pun di Tanah Air. Dan mereka berhasil bangkit dari keterpurukan untuk tetap jadi yang terbesar.

“Pukulan berat itu, kalau tak mematikan, akan membuat kita lebih kuat,” begitu kata orang bijak. Kekuatan ini saja, ditambah keuntungan menjadi perusahaan publik yang saham mayoritasnya masih dikuasai keluarga — harus transparan, tetapi cukup kuat untuk menahan keinginan investor minoritas yang biasanya lebih mementingkan keuntungan jangka pendek — agaknya cukup menjadi bekal bagi Kalbe menjadi perusahaan besar, bahkan terakbar di kawasan ASEAN.

URL : http://202.59.162.82/swamajalah/sajian/details.php?cid=1&id=4427

 

 

LIPI Biotechnology Research Center in collaboration with PT . Kalbe Farma Tbk held a meeting which was held on February 7, 2014 . The event was held in the auditorium of the Research Center for Biotechnology LIPI , Cibinong attended by 62 people from LIPI and Kalbe Farma .

Head of LIPI Biotechnology Research Center (Dr. Ir . Witjaksono , M.Sc ) in the opening of the event emphasized the importance of cooperation with the private sector .
Cooperation is supported by science , technology , equipment , human resources are formidable , networks and biodiversity that we have to be very fundamental role in doing good cooperation . Besides synergistic cooperation with the private sector is an appreciation of this sort of research capability in the country .
 
The first session of the event speakers from PT . Kalbe Farma ( Mr. Ahmad R. Utomo , PhD and Mr. Indra Bachtiar , PhD ) and the next session speakers from LIPI Biotechnology Research Center (Dr. Wien Kusharyoto , Dr. . Adi Santoso , Dr. . Abd M.Fuad , Dr. . Ratih Asmana Ningrum , Dr . Sukma Nuswantara ) . Last Session at the event to present three (3 ) speakers Dr . Andria Agusta from LIPI and Biological Research Center of Bioteknonologi LIPI Research Center (Dr. and Dr. Yantyati Widyastuti . Puspita Lisdiyanti ) .
Indra Bachtiar , PhD from PT . Kalbe Farma in his presentation on stem cell pertaining to the extent of the use of stem cells in medicine .
It can be used to treat various types of diseases , stem cells can also be used for medicinal beauty .
On this occasion Dr discussion session . Sukma Nuswantara posed the question whether man-made stem cells can be packed in capsules and swallowed by the patient after stem cells can serve as treatment with stem cells in general .

Questions are answered by Mr. Indra Bachtiar , Ph.D. which says that in cold conditions stemcell we can not survive more than 5 ( five ) hours .
 So even if the capsule has benefits , contained in a capsule that is certainly not a stem cell but is most likely a protein that may stimulate the cells in our body .
Metrotvnews.com , Jakarta : Stem cell therapy is believed to harbor great potential for treating a variety of diseases in the future .
This is related to the nature of stem cells capable of shape-shifting into any organ .

Not surprisingly , at this time , almost all of the global pharmaceutical companies seeking to develop stem cell products .

In Indonesia , Kalbe Farma pharmaceutical companies participate through its subsidiary ,
Stem Cell and Cancer Institute ( SCI ) .

According to principal investigator SCI Yuyus Kusnadi , one of SCI research being done is the development of stem cells from umbilical cord tissue baby .

” Based on our research , stem cells from umbilical cord tissue much better than stem cells from umbilical cord blood , ” said Yuyus at Iftar Kalbe Farma , some time ago .

Citing research results , Yuyus explained that stem cells obtained from the blood , including umbilical cord blood of infants , ideally used to treat diseases associated with blood , such as leukemia .

As for diseases associated with organ damage , such as osteoarthritis ( wear of cartilage ) , fracture , stroke , and kidney failure should ideally be treated with stem cells originally not of blood ( type of mesenchymal stem cells ) .

Mesenchymal stem cells can be obtained from the spinal cord .
However , making the spinal cord that is invasive and can only be done by competent medical personnel often complicate special .

That’s one reason the SCI develop mesenchymal stem cells from umbilical cord tissue .

Practice, further Yuyus , newborn umbilical cord is taken approximately 1 cm . ” Selected section closest to the placenta , because it is good . ”

Furthermore , umbilical cord tissue was processed in the laboratory to be taken puncanya cells .

Stem cells and cultured according to the dosage needed for later use in therapy . Later , the therapy is allogeneic . That is , patients given stem cells taken from others .

” At present , a new study early stages , will be followed by testing on animals , if successful will be forwarded to clinical trials in humans , ” said Yuyus . ( MI )

Editor : Basuki Eka Purnama

 

Pusat Penelitian Bioteknologi LIPI bekerjasama dengan PT. Kalbe Farma, Tbk menyelenggarakan pertemuan yang dilaksanakan pada tanggal 7 Februari 2014. Acara tersebut digelar di Auditorium Puslit Bioteknologi LIPI, Cibinong dihadiri 62 orang dari LIPI dan Kalbe Farma.

Kepala Pusat Penelitian Bioteknologi LIPI (Dr. Ir. Witjaksono, M.Sc) dalam pembukaan acara tersebut menekankan pentingnya kerjasama dengan pihak swasta.

Kerjasama yang disupport oleh sains, teknologi, peralatan, sumber daya manusia yang tangguh, network dan biodiversity yang kita miliki akan sangat fundamental peranannya dalam melakukan kerjasama yang baik. Disamping itu kerjasama yang sinergis dengan swasta semacam ini adalah bentuk apresiasi kemampuan peneliti dalam negeri.

Session pertama acara tersebut menghadirkan pembicara dari PT. Kalbe Farma (Bapak Ahmad R. Utomo, PhD dan Bapak Indra Bachtiar, PhD) dan session berikutnya menghadirkan pembicara dari Pusat Penelitian Bioteknologi LIPI (Dr. Wien Kusharyoto, Dr. Adi Santoso, Dr. Asrul M.Fuad, Dr. Ratih Asmana Ningrum, Dr. Sukma Nuswantara). Session terakhir dalam acara tersebut menghadirkan 3 (tiga) orang pembicara Dr. Andria Agusta dari Pusat Penelitian Biologi LIPI dan dari Pusat Penelitian Bioteknonologi LIPI (Dr. Yantyati Widyastuti dan Dr. Puspita Lisdiyanti).

Bapak Indra Bachtiar, PhD dari PT. Kalbe Farma dalam presentasinya tentang stem cell menyinggung tentang luasnya penggunaan stem cell dalam dunia kedokteran.

Selain dapat digunakan untuk mengobati berbagai macam jenis penyakit, stem cell juga dapat digunakan untuk obat kecantikan.

Pada kesempatan diskusi session ini Dr. Sukma Nuswantara melontarkan pertanyaan apakah stem cell yang dibuat manusia dapat dikemas dalam kapsul dan setelah di telan oleh pasien stem cell tersebut dapat berfungsi sebagaimana pengobatan dengan stem cell pada umumnya.

 

 

Pertanyaan tersebut dijawab oleh Bapak Indra Bachtiar, Ph.D. yang mengatakan bahwa dalam kondisi dingin stemcell kita ini tidak bisa bertahan lebih dari 5 (lima) jam.

Jadi kalaupun kapsul tersebut mempunyai manfaat, yang terdapat dalam kapsul itu tentu bukan stem cell tapi kemungkinan besar adalah protein yang mungkin dapat menstimulasi sel dalam tubuh kita.

Metrotvnews.com, Jakarta: Terapi sel punca diyakini memendam potensi besar untuk mengobati beragam penyakit di masa depan.

Hal itu terkait dengan sifat sel punca yang mampu berubah bentuk menjadi organ tubuh apa pun.

Tidak mengherankan, saat ini, hampir semua perusahaan farmasi global berupaya mengembangkan produk sel punca.

Di Indonesia, perusahaan farmasi Kalbe Farma turut ambil bagian melalui anak perusahaannya,

Stem Cell and Cancer Institute (SCI).


Menurut peneliti utama SCI Yuyus Kusnadi, salah satu penelitian yang tengah dilakukan SCI adalah pengembangan sel punca dari jaringan tali pusat bayi.

“Berdasarkan penelitian kami, sel punca dari jaringan tali pusat jauh lebih baik daripada sel punca dari darah tali pusat,” ujar Yuyus pada acara buka puasa bersama Kalbe Farma, beberapa waktu lalu.

Dengan mengutip hasil-hasil penelitian, Yuyus menjelaskan bahwa sel punca yang diperoleh dari darah, termasuk darah tali pusat bayi, idealnya digunakan untuk mengobati penyakit-penyakit yang terkait dengan darah, seperti leukemia.

Adapun untuk penyakit-penyakit yang terkait dengan kerusakan organ, seperti osteoartritis (ausnya tulang rawan), patah tulang, stroke, dan gagal ginjal idealnya diterapi dengan sel punca yang asalnya bukan dari darah (sel punca jenis mesenkimal).

 

Sel punca mesenkimal bisa diperoleh dari sumsum tulang belakang.

Namun, pengambilan sumsum tulang belakang yang bersifat invasif dan hanya bisa dilakukan oleh tenaga medis berkompetensi khusus kerap menjadi penyulit.

 

Itulah yang menjadi salah satu alasan SCI mengembangkan sel punca mesenkimal dari jaringan tali pusat.

Praktiknya, lanjut Yuyus, tali pusat bayi baru lahir diambil sekitar 1 cm. “Dipilih bagian yang terdekat dengan plasenta, karena lebih bagus.”

Selanjutnya, jaringan tali pusat itu diolah di laboratorium untuk diambil sel puncanya.

 

Sel punca lalu dibiakkan sesuai dosis yang dibutuhkan untuk kemudian digunakan dalam terapi. Nantinya, terapi bersifat alogenik. Artinya, pasien diberi sel punca yang diambil dari orang lain.

“Saat ini, penelitian baru tahap awal, nantinya akan disusul dengan ujicoba kepada hewan, kalau berhasil akan diteruskan dengan uji klinis pada manusia,” terang Yuyus. (MI)

 

 

 

Editor: Basuki Eka Purnama

 

 

 

 

 

 

 

 

 

 

 

Kebijakan Menteri Riset Dan Teknologi

The Indonesia Menistry Reaseach And Development have starting to built th Science Parks in order to get theinteraction between the REseachers in the world , traders and Government but this project have develoed in many years agot but not advanced

With the moving of the world economic from western to Asia , Indonesian must use this momentum maximaly

The Government target are

TO STIMULATING INOVATION,REASEACHING AND CREATIVATION

With the giving of tax incentive for that field

 

Dr Iwan Notes

Science Parlks too broad notion example we see the difficulties faced by Prof. Sangkot Marzuki of the Eijkman institute that examines the broad aspects of gene and disease that so much so that no visible results, see Pusdokkes Indonesian National Police Department has succeeded with its DVI DNA, according to the opinion of Dr. Iwan preferably in ranging from scientific research that is most needed at this time as
Stem cell gene Biological Research Center

 

Gagasan Science Parks terlalu luas contohnya kita lihat kesulitan yang dihadapi Prof Sangkot Marzuki dengan lembaga Eijkman yang meneliti terlau luas aspek gen dan penyakit yang jumlahya sangat banyak sehingga tidak kelihatan hasilnya ,lihat pusdokkes POLRI telah berhasil dengan DNA DVI nya ,menurut pendapat Dr Iwan sebaiknya di mulai dari penelitian ilmiah yang paling diperlukan saat ini seperti

Gen Biological stem cell Research center

 

Danny Halim , dr . ( researchers Stem Cell Research Working Group – ubuntu , members of the Association of Indonesian Stem Cells ( ASPI ) )
– Harry Murti , S.Si. ( Researchers in the Stem Cell and Cancer Institute ( SCI ) , a member ASPI )
– Ferry Sandra , drg , PhD , LFIBA ( SCI founder , co-founder of ASPI , SCI Director & Chairman of the Executive Board ASPI )
– Prof . Arief Boediono , DVM , PhD ( Professor of IPB , IPB researchers in particular fields of parthenogenesis , governing board ASPI )
– Dr . Tono Djuwantono , dr , SpOG ( K ) ( consultant fertility & reproductive endocrinology ubuntu , researchers at the Stem Cell Research Working Group – ubuntu , members ASPI )
– Boenjamin Setiawan , dr , PhD ( founder of SCI with Sandra Ferry , one of the founders of ASPI )

Disclosure of privileged number of potential stem cell ( stem cells ) in the late 20th century is a major phenomenon in the world of medicine . With its characteristics , stem cell -based medical technology promises hope of a total cure for patients with degenerative diseases such as stroke , Alzheimer’s , diabetes mellitus , Parkinson’s , and heart failure .

Stem Cell – Basic Theory & Clinical Application This is a book that presents a reliable scientific explanation of the basic theories that underlie the use of stem cells in the clinical world .

TABLE OF CONTENTS
Chapter 1
Definitions and Basic Stem Cell Biology
– Stem Cell Characteristics
– Types of Stem Cell

Chapter 2
Diversity of Stem Cell Type : Sources , Isolation Technique , Kulturisasi , Differentiation , and Kriopreservasinya
– Embryonic Stem Cell : Sources & Engineering isolation
– Adult Stem Cell source , identification , and isolation techniques
– Induction of Stem Cell Results ( Induced Pluripotent Stem Cell , iPS )
– Stem Cell Type Other : Fetal Stem Cell and Cancer Stem Cell
– Kulturisasi and Stem Cell Differentiation in In Vitro
– Keep Frozen ( Stem Cell Cryopreservation )

Chapter 3
Mechanism In Stem Cell Regeneration
– Homing
– Mechanism Regeneration by Stem Cell Network
– The use of Stem Cell in Chapter 4 Potential Gene Therapy in the World Stem Cell Research and Clinical Applications
– Aging ( Aging )
– Organ Transplant Exit For Degenerative Diseases
– New Hope For Cell Transplant Patients with Degenerative Diseases
– Role in Stem Cell Therapy Degenerative Diseases
– Role of Stem Cell in Degenerative Disease Diagnosis

SPECIFICATIONS
Year of Publication : 2010
Field of Study : Medicine ( General , Dental , Animal ) , Biology , Pharmacy
Book Size : 15.7 x 24 cm
Hlm Number : 160
Color : Full Color
Paper : HVS 70 g
Cover : Hardcover
Book Code : 0076100030
ISBN : 978-979-075-330-3
   

 Application of a modified method for the isolation of stem cells from lipoaspirates in a basic lab
Caroline T. Sardjono1 , 2 , Melina Setiawan1 , Frisca1 , Virgi Saputra3 , gwendy Aniko4 , Ferry Sandra1

1 Stem Cell and Cancer Institute
2 Microbiology Department , Faculty of Medicine , Maranatha Christian University , Bandung , Indonesia
3 Kalbe Farma Tbk
4 Mitra Kemayoran Family
abstract
The purpose Lipoaspirate containing mesenchymal stem cell numbers are much , so lipoaspirate now become a source of mesenchymal stem cells with huge potential for research and for clinical applications . Simple method mesenchymal stem cell isolation that can be applied on the basis of the laboratory will facilitate the development of stem cell research in developing countries . Hopefully, the results of this study can enhance the development of stem cell research in Indonesia .

Methods Lipoaspirate digested with type I collagenase enzyme then carried filtration .
 Purification of mesenchymal stem cells is done by culturing the cells for 2-3 days followed by disposal of the supernatant .
Confirmation of a homogeneous population of cells with the analysis performed by flowcytometry method in accordance with the criteria of the Mesenchymal and Tissue Stem Cell Committee of the International Society of Cell Therapy .
Results of mesenchymal stem cells that can be obtained using this procedure are as 16.41 ± 8.22 x 108 cells per 120 ml lipoaspirate . Cell culture results showed fibroblastic morphology , in accordance with the characteristics of mesenchymal stem cells and successfully purified from other cells . This was confirmed by flowcytometry analysis showed that CD105 expression , in the absence of expression of HLA – Class II , CD 45 , CD 34 , CD14 , and CD19 .

Conclusion This study showed that mesenchymal stem cells can be isolated from lipoaspirate is simple . This procedure is very possible to be done in a laboratory basis . ( Med J Indones 2009; 18:91-6 )

 

 

Danny Halim, dr. (peneliti Stem Cell Research Working Group-UNPAD, anggota Asosiasi Sel Punca Indonesia (ASPI))
– Harry Murti, S.Si. (peneliti di Stem Cell & Cancer Institute (SCI), anggota ASPI)
– Ferry Sandra, drg, PhD, LFIBA (pendiri SCI, salah satu pendiri ASPI, Direktur SCI & Ketua Dewan Pelaksana ASPI)
– Prof. Arief Boediono, drh, PhD (Guru Besar IPB, peneliti di IPB khususnya bidang partenogenesis, dewan pelaksana ASPI)
– Dr. Tono Djuwantono, dr, SpOG(K) (konsultan fertilitas & endokrinologi reproduksi UNPAD, peneliti di Stem Cell Research Working Group-UNPAD, anggota ASPI)
– Boenjamin Setiawan, dr, PhD (pendiri SCI bersama Ferry Sandra, salah satu pendiri ASPI)

 

 

Terungkapnya sejumlah potensi istimewa stem cell (sel punca) pada akhir abad ke-20 adalah suatu fenomena besar dalam dunia kedokteran. Dengan karakteristik yang dimilikinya, teknologi kedokteran berbasis stem cell menjanjikan harapan kesembuhan total bagi penderita penyakit degeneratif seperti stroke, Alzheimer, diabetes melitus, Parkinson, maupun gagal jantung.

Stem Cell – Dasar Teori & Aplikasi Klinis ini adalah buku yang menyajikan penjelasan ilmiah terpercaya mengenai dasar teori yang menjadi landasan penggunaan stem cell dalam dunia klinis.

 

 

DAFTAR ISI
Bab 1
Definisi dan Biologi Dasar Stem Cell
– Karakteristik Stem Cell
– Jenis-jenis Stem Cell

Bab 2
Keragaman Jenis Stem Cell: Sumber,Teknik Isolasi, Kulturisasi, Diferensiasi, dan Kriopreservasinya
– Stem Cell Embrionik: Sumber & Teknik Isolasinya
– Stem Cell Dewasa: Sumber, Identifikasi, dan Teknik Isolasinya
– Stem Cell Hasil Induksi (induced Pluripotent Stem Cell, iPS)
– Stem Cell Jenis Lain: Stem Cell Fetal dan Stem Cell Kanker
– Kulturisasi dan Diferensiasi Stem Cell secara In Vitro
– Simpan Beku (Kriopreservasi Stem Cell)

 

Bab 3
Mekanisme Stem Cell Dalam Regenerasi
– Homing
– Mekanisme Regenerasi Jaringan oleh Stem Cell
– Penggunaan Stem Cell dalam Terapi Gen Bab 4 Potensi Stem Cell dalam Dunia Riset dan Aplikasi Klinis
– Aging (Penuaan)
– Transplantasi Organ Sebagai Jalan Keluar Penyakit Degeneratif
– Transplantasi Sel Sebagai Harapan Baru Penderita Penyakit Degeneratif
– Peran Stem Cell dalam Terapi Penyakit Degeneratif
– Peran Stem Cell dalam Diagnosis Penyakit Degeneratif

SPESIFIKASI
Tahun Terbit : 2010
Bidang Studi : Kedokteran (Umum, Gigi, Hewan), Biologi, Farmasi
Ukuran Buku : 15,7 x 24 cm
Jumlah Hlm : 160
Warna : Full Color
Kertas : HVS 70 g
Cover : Hardcover
Kode Buku : 0076100030

 

 

 

 

 


ISBN : 978-979-075-330-3

 

 

 

Top of Form

 

 

 

 

 

Application of a modified method for stem cell isolation from lipoaspirates in a basic lab

Caroline T. Sardjono1,2, Melina Setiawan1, Frisca1, Virgi Saputra3, Gwendy Aniko4, Ferry Sandra1

 

 

1 Stem Cell and Cancer Institute

2 Microbiology Department, Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia

3 Kalbe Farma Tbk

4 Mitra Keluarga Kemayoran

Abstrak

Tujuan Lipoaspirate mengandung jumlah sel punca mesenkimal yang banyak, sehingga lipoaspirate kini menjadi sumber sel punca mesenkimal yang sangat potensial bagi riset maupun untuk aplikasi klinis. Metode sederhana isolasi sel punca mesenkimal yang dapat diaplikasikan pada laboratorium dasar akan memfasilitasi perkembangan riset sel punca di negara berkembang. Diharapkan, hasil studi ini dapat meningkatkan pengembangan riset sel punca di Indonesia.

 

Metode Lipoaspirate dicerna dengan enzim collagenase type I kemudian dilakukan filtrasi.

Pemurnian sel punca mesenkimal dilakukan dengan mengkultur sel selama 2-3 hari disusul dengan pembuangan supernatan.

Konfirmasi populasi yang homogen dilakukan melalui analisis sel dengan metode flowcytometry sesuai dengan kriteria dari Mesenchymal and Tissue Stem Cell Committee of the International Society of Cell Therapy.

Hasil Sel punca mesenkimal yang dapat diperoleh dengan menggunakan prosedur ini adalah sebanyak 16,41 ± 8,22 x 108 sel per 120 ml lipoaspirate. Sel hasil kultur menunjukan morfologi fibroblastik, sesuai dengan karakteristik sel punca mesenkimal dan berhasil dipurifikasi dari sel lainnya. Hal ini dikonfirmasi dengan analisis flowcytometry yang menunjukan ekpresi CD105, tanpa adanya ekspresi HLA-Class II, CD 45, CD 34, CD14, and CD19.

 

 

Kesimpulan Studi ini menunjukan bahwa sel punca mesenkimal dapat diisolasi dari lipoaspirate secara sederhana. Prosedur ini sangat memungkinkan untuk dilakukan di laboratorium dasar. (Med J Indones 2009; 18:91-6)

Abstract

Aim Lipoaspirate, a wasted by product from liposuction procedure recently has been shown to contain abundant mesenchymal stem cells (MSCs). MSCs have been studied in many research areas to regenerate many cell lineages including, myogenic, cardiomyogenic, and angiogenic lineages. The large quantity of MSCs in lipoaspirate, makes it an attractive source for stem cells used in research and clinical applications. A simplified method which is suitable to be performed in a basic laboratory will facilitate development of stem cell research in developing countries. Therefore the outcomes from this study are expected to encourage the progress of stem cell research in Indonesia.

Methods Lipoaspirate was digested using collagenase type I, followed by a basic filtration method. Purification of MSCs was done by cell culture for 2-3 days followed by supernatant removal. To confirm the homogenous population of MSCs, an analysis using flowcytometry was performed based on the MSCs minimal criteria developed by Mesenchymal and Tissue Stem Cell Committee of the International Society of Cell Therapy.

Resuts MSCs were able to be obtained at 16.41 ± 8.22 x 108 cells per 120 ml lipoaspirate. The cultured cells showed fibroblastic morphology which is characteristic for MSCs and were able to be purified from non-MSCs cells. This was confirmed by flowcytometry assay showing expression of CD105 and the absence of HLA-Class II, CD 45, CD 34, CD14, and CD19.

Conclusions This study has shown that it was feasible to isolate messenchymal stem cell from human lipoaspirate. The procedure was practicable to be performed within a basic laboratory. (Med J Indones 2009; 18: 91-6)

Key words: mesenchymal stem cell, lipoaspirate, stem cell isolation technique

Med J Indones

92

Sardjono et al.

Liposuction is one of the most popular cosmetic surgical procedures worldwide with an estimated one million liposuctions performed annually.1 Lipoaspirate, which often wasted as by product from liposuction procedure recently has been shown to contain abundant mesenchymal stem cells (MSCs).2

The use of lipoaspirate as a source for stem cells offers a far less invasive procedure for cell sampling than the aspiration of bone marrow.

Moreover, the numbers of stem cells obtained from lipoaspirate are reportedly higher in lipoaspirate than its bone marrow counterpart.3

The average of MSCs occurrence in lipoaspirate was 1.2 ± 0.3 per 100 Adipose-derived Cells, much higher compared to 1 MSC per 50,000 bone marrow nucleated cells.4

The clinical utilizations of MSCs from adipose tissue have been reported in the regenerative-reconstructive surgical procedures such as calvarial repair, tracheal repair, fistula healing in Crohn’s disease, osteogenesis imperfecta, breast reconstructions, and tissue reconstruction of post-radiotherapy damage.5-8 Recently, MSC therapies have been extended into treatment for cardiovascular diseases including acute myocardial infarction and chronic heart failure.9

Moreover, several types of medical device have been developed in order to fulfill the high demand of procedures that can cater quick isolation with high yield of MSCs from adipose tissue.6,10

Moreover, there have been several providers offering an option for patients undergo liposuction to be able to store their stem cells in cryopreservation facility.11 This option allows the individuals to take benefits from their own stem cells for future applications.

Mesenchymal stem cells (MSCs), also known as marrow stromal cells or mesenchymal progenitor cells, are defined as self-renewable, multipotent progenitor cells with the capacity to differentiate into several distinct mesenchymal lineages. MSCs can be induced to differentiate into adipogenic, chondrogenic, and osteogenic linages in the laboratory using appropriate cocktails of growth factors and supplements (Figure 1).12

Furthermore, MSCs have been studied in many research area to regenerate cell linages including, myogenic, cardiomyogenic lines, and also differentiate into neurogenic, angiogenic and hepatic lineages.10,13,14 Despite their capability to differentiate in vivo and in vitro into mesenchymal lineages, MSCs have also been shown to have an important role in the maintenance of haematopoiesis.13 and legends Figure 1. Multilineages Differentiation of Mesenchymal Stem Cell (MSC) and additives used to stimulate cell differentiation

ChondrocyteOsteoblastAdipocyteChondrogenicDifferentiation markers-Proteoglycans-Sulfated glycosaminoglycans(stained using SafraninO, Fast Green, or AlcianBlue)OsteogenicEarly markers-Upregulatedalkaline phosphatase(detected by naphtol-based chemical stain)-Late markers-Bone sialoprotein-Osteocalcin-Osteonectin(stained von Kossa, Alizarin Red)AdipogenicDifferentiation markers-Intracellular Lipid vacuoles(stained using Oil Red-O)TGF-􀁅BMP-6High dose dexamethasone1-methyl-3-isobutylxanathineIndomethacinLow dose dexamethasoneL-ascorbic acid 2 phosphate􀁅-glycerophosphateBMP-2, -6, -9MesenchymalStem CellChondrocyteOsteoblastAdipocyteChondrogenicDifferentiation Cell100􀁐m100m

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 1. Multitineages differentiation of Mesenchymal Stem Cell (MSC) and additives used to stimulate cell differentiation

93 Vol.18, No.2, April – June 2009 Stem cell isolation from lipoaspirates

Many publications have shown MSCs present and able to be isolated from many tissue types, such as bone marrow, trabecular bone, periosteum, synovial membrane, muscle, dermis, pericytes, blood, and adipose tissue.15-17 These demonstrate the potential of MSCs in addition to their plasticity and their usefulness in cell therapy. It is also of interest that neither autologous nor allogeneic MSCs induce any immunoreacti-vity in the host upon local transplantation or systemic administration.18,19 Finally, the large quantity of MSCs in lipoaspirates, makes it an attractive source for stem cells isolation for research and clinical applications.14,17 An optimized method which is suitable to be performed in a basic research laboratory clearly will facilitate development for basic laboratory to conduct stem cell research. Therefore the aim of this study was to modify the method of Zuk et al so that it would perform well in a minimal laboratory setting.

Methods

Mesenchymal stem cell isolation from lipoaspirates

All protocols were reviewed and approved by the Stem Cell and Cancer Institute Institutional Review Board prior to the study (Proposal number 13/IRB/SCI/KF/2008).

Lipoaspirates were obtained with informed consent from individuals undergoing tumescent liposuction surgery in hospitals collaborated with Stem Cell and Cancer Institute.

Lipoaspirates were stored at 2–8°C for no longer than 24 hours before they were used. Methods used to isolate the mesenchymal stem cells from lipoaspirate were adapted from methods in Zuk et al.17

The raw lipoaspirates (120 ml) were diluted with equal volume of Phosphate Buffer Saline (PBS) and were divided evenly in 50ml-tubes (Figure 2).

The diluted lipoaspirates were centrifuged at 430 × g for 10 minutes continously at 20oC.

After centrifugation, the target cell–containing lipid phase was removed from the top and transferred in to new tubes and diluted with an equal volume of PBS.

 

 

This washing step was repeated twice followed by further an equal volume dilution of cell-containing lipid fraction with pre-warmed (37oC) 0.075% collagenase type I (Sigma) in PBS. Enzyme digestion was done by incubation at 37°C for 30 minutes on an orbital shaker (Figure 3).

After digestion, enzyme activity was neutralized by adding equal volume of Dulbecco’s modified Eagle’s medium (DMEM) containing 10% Fetal Bovine Serum (FBS). Digested product then subjected to centrifugation at 600×g for 10 minutes. Pellet was resuspended in DMEM with 10% PBS then filtered through a 100-

μm strainer mesh attached to a vacuum-pump to remove cellular debris (Figure 4).

Collected cells after filtration were then ready for utilization. An aliquot was taken for cell count using hemocytometer under a light microscope to determined cell yields. Counts and viability were determined with a hemocytometer and the trypan blue dye exclusion technique. Briefly, 10 l trypan blue stock solution (0.4% w/v) was mixed with 10 l cells suspension, incubated for 3 minutes at room temperature then cells were counted in a hemocytometer chamber. With this method, dead cells appear blue and were therefore distinguishable from viable cells.

 

Figure 3. Procedure to isolate mesenchymal stem cells from lipoaspirate using collagenase was done by incubation at 37oC for 30 minutes on a rotating shaker

 

Figure 4. Filtration procedure by using a 100-

m strainer mesh attached to a vacuum pump to remove cellular debris18Figures and legends Figure 1. Multilineages Differentiation of Mesenchymal Stem Cell (MSC) and additives used to stimulate cell differentiation Figure 2. Procedure to dilute lipoaspirate by adding equal volume of Phosphate Buffer Saline (PBS) prior to the washing step

ChondrocyteOsteoblastAdipocyteChondrogenicDifferentiation CellChondrocyteOsteoblastAdipocyteChondrogenicDifferentiation markers-Proteoglycans-Sulfated glycosaminoglycans(stained using SafraninO, Fast Green, or AlcianBlue)OsteogenicEarly markers-Upregulatedalkaline phosphatase(detected by naphtol-based chemical stain)-Late markers-Bone sialoprotein-Osteocalcin-Osteonectin(stained von Kossa, Alizarin Red)AdipogenicDifferentiation markers-Intracellular Lipid vacuoles(stained using Oil Red-O)TGF-􀁅BMP-6High dose dexamethasone1-methyl-3-isobutylxanathineIndomethacinLow dose dexamethasoneL-ascorbic acid 2 phosphate􀁅-glycerophosphateBMP-2, -6, -9MesenchymalStem Cell100􀁐m100m

Figure 3. Procedure to isolate mesenchymal stem cells from lipoaspirate using collagenase was done by incubation at 37 °C for 30 minutes on a rotating shaker Figure 4. Filtration procedure by using a 100-

μm strainer mesh attached to a vacuum-pump to remove cellular debris

Figure 2. Procedure to dilute lipo-aspirate by adding equal volume of Phosphate Buffer Saline (PBS) prior to the washing step

19

 

 

Figure 3. Procedure to isolate mesenchymal stem cells from lipoaspirate using collagenase was done by incubation at 37 °C for 30 minutes on a rotating shaker Figure 4. Filtration procedure by using a 100-

μm strainer mesh attached to a vacuum-pump to remove cellular debris 94 Med J Indones Sardjono et al.

Mesenchymal stem cell culture

The simplest technique to purify MSC from other contaminating cells was done by allowing the cells to adhere on plastic-surfaced disc. Cells were seeded at 1.3x105cells/cm2 in M-199 medium (Gibco 11150) supplemented with 20 % Fetal Bovine Serum (Invitrogen 26140-079), 100 unit/ml penicillin and 0.1 mg/ml streptomycin antibiotics (Sigma P0781), then kept in 37oC, 5% CO2. After 2-3 days unwanted cells (non-MSC cells and debri) were removed by two washes with medium and expanded to reach 80% confluence. In another 6-7 days, adherent cells were detached using 0.25% trypsin EDTA solution (Sigma T4049), then M-199 medium + 20% FBS was used to inactivate trypsin. Detached cells with fibroblast-like morphology were cultured in another flask with cell density of 1.2×105 cells/cm2 for 1 week or until confluence was achieved.

 

Flo

wcytometry assay to determine MSC homogenous population

To confirm the simplified protocols were able to isolate good quality MSCs, several assays were conducted. MSCs have been known to express CD105 and deficient in the expression of HLA Class II, CD34 and CD45.

Expression HLA Class II molecules were determined using PE fluorescein conjugated monoclonal antibodies against HLA Class II (abcam 23901). Antibodies directed against CD45 were conjugated with FITC (BD 555482) and CD34 with FITC (BD 348053) incubated at 4oC in the dark for 15 minutes. Mouse IgG1-FITC (BD 349041) isotype matched negative controls were used to define background staining. The cells then analysed by flow analysis using FACSCalibur 3 argon laser 488nm (Becton Dickinson).

Results

Mesenchymal stem cell isolation and culture

Using the methods described, MSCs were able to be obtained at 16.41 ± 8.22 x 108 cells per 120 ml lipo-aspirate which have provided an abundant number of cells for further used (Table 1). The simplified method has proven to be gentle enough for the cells as shown by the high viability cells obtained (viable cells 92.57% ± 4.5%).

 

 

 

 

 

Table 1. Lipoaspirate donors and cell yield

Donor No.

 

Lipoaspirate volume (ml)

 

Cell yield

 

(x 108)

 

Viability

 

(%)

 

1

 

2

 

3

 

4

 

120

 

120

 

120

 

120

 

4.27

 

20.55

 

22.2

 

18.6

 

90.05

 

91.95

 

89.16

 

99.12

 

average

 

120

 

16.405

 

92.57

 

 

 

 

 

 

Iqbal Rais Stem Cell Patient First in Indonesia
  
TEMPO.CO , Surabaya :
Secretary of the Center for Regenerative Medicine and Stem Cell Hospital Dr . Atopic Dermatitis , Purwati , said Iqbal Rais patient immediately underwent stem cell therapy ( stem cells ) on Wednesday next week .

 Young director , Iqbal Rais , 29 years gush movie trilogy The Tarix Jabrix , lying in hospitals Soetomo weak due to a blood cancer ( leukemia ) .

To Tempo , Purwati said components taken from tissue stem cells bonmero aka spinal cord patients .
Currently , Iqbal was undergoing chemotherapy at the hospital .
” It’s still isolated . Probably , stem cell therapy started next Wednesday , ” said Purwati told Tempo in Jakarta, Friday, 2013 .

Purwati knowledge , Iqbal Rais is the first leukemia patient using stem cell therapy in Indonesia .
 Stem Cell Therapy for leukemia cases abroad , he said , the average success rate of 80 percent .
 Purwati hope , Iqbal body condition is getting better with Stem Cell therapy .
 By injection into a vein Daran , stem cell is inserted into the body Iqbal .
Stem Cell will replace body tissue damaged by the attack cancer cells in blood.

The plan , and the team will Purwati Iqbal menerapi three times Stem Cell therapy . If the patient’s condition indicates a positive development , the use of stem cell therapy to the patient’s body tried really recovered .

Since the first new case of childhood leukemia through stem cell therapy , Purwati reluctant to insure success rate . He hopes stem cell therapy on body Soetomo Hospital Dr Iqbal has a higher success rate than overseas .
 Once therapy , it was USD 25 million charge to the patient . ” It ‘s still a clinical trial . Costs so much, ” he said .

DIANANTA P. Sumedi

Iqbal Rais Pasien Stem Cell Pertama di Indonesia

 

 

 

 

 

 

TEMPO.CO

 

 

 

 , Surabaya

 

:

Sekretaris Pusat Kedokteran Regeneratif dan Stem Cell RSUD Dr. Soetomo, Purwati, mengatakan pasien Iqbal Rais segera menjalani terapi stem cell (sel punca) Rabu,pekan depan.

 

 

 

Sutradara muda, Iqbal Rais, 29 tahun yang membesut film trilogi The Tarix Jabrix, tergolek lemah di RSUD dr Soetomo karena terserang kanker darah (leukemia).

 

 

 

 

Kepada 

Tempo, 

 

Purwati menuturkan komponen stem cell diambilkan dari jaringan bonmero alias sumsum tulang belakang pasien.

Saat ini, Iqbal masih menjalani kemoterapi di rumah sakit tersebut.

 

“Sekarang masih diisolasi. Mungkin, terapi stem cell mulai dilakukan Rabu pekan depan,” kata Purwati kepada Tempo di Surabaya, Jumat 2013.

Sepengetahuan Purwati, Iqbal Rais merupakan pasien leukimia pertama yang menggunakan terapi stem cell di Indonesia.

 

Terapi Stem Cell untuk kasus leukimia di luar negeri, kata dia, tingkat keberhasilannya rata-rata 80 persen.

 

Purwati berharap, kondisi tubuh Iqbal semakin membaik dengan terapi Stem Cell.

 

Melalui injeksi ke pembuluh daran, stem cell dimasukkan ke tubuh Iqbal.

 

Stem Cell akan menggantikan jaringan tubuh yang rusak akibat serangan sel-sel kanker darah.

Rencananya, Purwati dan tim akan menerapi Iqbal sebanyak tiga kali terapi Stem Cell. Bila kondisi badan pasien menunjukkan perkembangan positif, penggunaan terapi Stem Cell dicoba hingga tubuh pasien benar-benar pulih.

 

 

 

Karena baru pertama menangani kasus leukimia melalui terapi Stem Cell, Purwati enggan memastikan tingkat keberhasilannya. Ia berharap terapi Stem Cell RSUD Dr Soetomo pada tubuh Iqbal memiliki tingkat keberhasilan lebih tinggi ketimbang di luar negeri.

 

Sekali terapi, pihaknya mengenakan biaya Rp 25 juta kepada pasien. “Ini kan masih uji klinis. Jadi biayanya segitu,” kata dia.

 

 

 

 

 

 

DIANANTA P. SUMEDI

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Terapi Stem Cell di Jakarta

Stem cell therapy in Jakarta

Mesenchymal stem cell therapy for cartilage defects and fracture reconstruction in RSCM – FKUI
Written by Dr. Okki Ramadian SpPD
Wednesday, January 6, 2010 09:01
Cluster Muscles , Bones and Joints have been preparing for clinical trials ” mesenchymal Stem Cell Therapy for Cartilage Defects and Fracture Reconstruction ” . The principle clinical trial in the case of cartilage is a form of treatment decision marrow from the iliac crest bone patients , cultured bone marrow For isolation and proliferation Bone marrow stromal stem cells ( bMSCs ) or differentiation towards kondrogenesis , and bMSCs implantation in cartilage defect cases , which is symptomatic cartilage defects with an area of ​​more than 4 square meters .
MORE …

  
Biomedical research mesenchyme stem cells
Written by dr Radiana MBiomed
Monday, April 19, 2010 07:57
The development of biomedical research on multipotent stromal mesenchymal cells or more popularly known as mesenchymal stem cells is very fast and lively . Many research lab and biomedical researchers who jumped into the research area and the number is increasing along with the increase in the number of publications and clinical applications of mesenchymal stem cell therapy . This phenomenon on the other hand the negative impact of ambiguity and inconsistency of the results of research in the field of mesenchymal stem cells .
MORE …

  
Regulatory Guide Selpunca India
Written by dr . M. Adi Firman
Wednesday, July 15, 2009 15:01
Each country must have its own guide on the use of stem cells . One of them is India . Here is a guide selpunca regulations in force in India .
For more information , please click on the Stem Cell Regulation in India , the information in the form of pdf files .
You can download these files via the Download Zone menu ( make sure you have registered as a member ) .
  
The role of endothelial progenitor cell ( EPC ) on Neovascularization
Written by dr.Saut Nababan / dr.Okki , SpPD
Wednesday, August 11, 2010 08:10
EPC are cells that have the ability to divide and differentiate into endothelial cells . EPC is part of the stem cells that are more mature and unipoten . Clinically , the EPC can improve conditions of disease that begins with damage to the endothelial cells , both anatomically / structurally and functionally , through the mechanism of neovascularization . The researchers believe that in the bone marrow and peripheral blood flow cells are capable of dividing and differentiate into endothelial cells and ischemic tissue repair due to damage to blood vessel walls . These cells are called endothelial progenitor cells or EPC .
MORE …

  Autologous Stem Cell Transplantation for Autoimmune Disease : Results of a Cohort Study
Written by Dr. Excellency , Dr. Okki SpPD
Wednesday, April 14, 2010 08:48
Autoimmune disease which affects 5-8 % of the population in the world , accounting for short-term morbidity and mortality and long-term meaningful . Although conventional immunosuppressant therapies and new biological agents to control the severe autoimmune disease , this treatment modality is rarely curative . Severe systemic autoimmune diseases such as multiple sclerosis ( MS ) , systemic sclerosis ( SSC ) , rheumatoid arthritis ( RA ) , systemic lupus erythematosus ( SLE ) , juvenile idiopathic arthritis ( JIA ) , hematologic immune cytopenia ( HIC ) , and Crohn’s disease is difficult to treat ; therefore , other treatment strategies are needed . Since 1996 , autologous stem cell transplantation has been performed for the treatment of severe autoimmune diseases refractory to conventional treatment .
MORE …

  
Stem Cell Therapy Regulatory Guide from the FDA
Written by dr . M. Adi Firman
Saturday, July 18, 2009 08:55
Selpunca technological development and adult stem cell based therapy is increasingly prevalent . This prompted the FDA ( Food and Drug Administration ) in 2006 , issued regulations and guidelines on the production and marketing of stem cell -based therapies ( stem – cell – based therapy ) .
Click the following link to listen to the complete guide from the FDA . FDA Regulation of the Stem Cell -Based Therapies .

  

Articles …
• Seminar day : Stem Cell Update ; May 8, 2010
• Clinical Trials Peripheral Blood Stem Cell Implantation in Cardiac Infarction , RSCM – FKUI
• Stem Cell Development Cooperation Iran-FKUI/RSCM
• Stem Cell Clinical Implementation Guide
• Learning from the Dutch Experience Stem Cell Center
• Cooperation Stem Cell Faculty of medicine / RSCM with Leiden Medical Center
• Questions for Materials Posts
• Stem Cell Guide for General
• Stem Cell Therapy in Autoimmune Disease
• Recommendations Cord Blood Storage Services Center of the Royal College of Obstetrics & Gynecology
• Clinical Trials Stem Cell Therapy in Peripheral Arterial Disease type 2 DM
• Presentation Materials Symposium Selpunca
• Prof. Dr. visits . Eduard Willem Fibbe PhD
• Development of Stem Cell Symposium Faculty of medicine / RSCM Success Held

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• The role of endothelial progenitor cell ( EPC ) on Neovascularization
• Assessing Biomedical mesenchyme stem cells
• Cooperation Stem Cell Faculty of medicine / RSCM with Leiden Medical Center
• Autologous Stem Cell Transplantation for Autoimmune Disease : Results of a Cohort Study
• Seminar day : Stem Cell Update ; May 8, 2010
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Dahlan Iskan finance therapy ” stemcell ” Putu Wijaya
Friday, November 29, 2013 22:53 pm | 3479 Views
 
SOE Minister Dahlan Iskan ( AFP PHOTOS / Dhoni Setiawan )
Jakarta ( ANTARA News ) – State Enterprises Minister Dahlan Iskan Putu Wijaya help writers who suffered a stroke with pay for treatment through therapy ” stemcell ” .

A press release received by ANTARA here on Friday , said Dahlan was once a colleague Putu Wijaya in the magazine ” Tempo ” Putu visit at his home in Chester district , South Tangerang .

Dahlan come with a medical expert ” stemcell ” from Surabaya , known as the expert ” stemcell ” in Indonesia .

To Putu , Dahlan became a fan of short stories and novels Putu , telling that someone who had a stroke likely to be cured with therapy back ” stemcell ” .

Dahlan as well as introducing new physician home teaching ” stemcell ” in Tokyo and Amsterdam it . ” Thank God , Mas Putu very enthusiastic to join the discussion and states are willing to undergo treatment , ” Dahlan said via text message .

Dahlan said the cost of treatment with the ” stemcell ” it becomes a dependent personality. ” I hope that the Lord to heal us of this great artist , ” said Dahlan .

Putu Wijaya known to have suffered a stroke in early October . As a result of stroke , 69 -year -old artist was not able to work anymore . A number of colleagues and fans then took the initiative to raise funds after reading the news on social media that Putu can not afford the cost of treatment .

Editors : Ruslan Burhani

Terapi sel punca mesenkimal untuk defek tulang rawan dan rekonstruksi fraktur di RSCM-FKUI

 

 

 

Ditulis oleh dr Okki Ramadian SpPD   

 

Rabu, 06 Januari 2010 09:01

 

 

 

 

 

Klaster Otot, Tulang dan Sendi telah mempersiapkan uji klinis “Terapi Sel Punca Mesenkimal untuk Defek Tulang Rawan dan Rekonstruksi Fraktur”.

Prinsip uji klinis pada kasus tulang rawan adalah berupa penanganan yang berupa pengambilan sum-sum tulang dari krista iliaka pasien, kultur bone marrow utk isolasi dan proliferasi Bone marrow stromal stem cells (bMSCs) ataupun diferensiasi kearah kondrogenesis, dan implantasi bMSCs pada kasus defek tulang rawan, yaitu defek tulang rawan simtomatik dengan luas lebih dari 4 meter persegi.

 

 

 

SELENGKAPNYA…

 

 

 

 

 

 

Telaah Biomedik Sel Punca Mesenkim

 

 

 

Ditulis oleh dr Radiana MBiomed   

 

Senin, 19 April 2010 07:57

 

 

 

 

 

Perkembangan riset biomedik terhadap sel mesenkim stroma multipoten atau lebih populer disebut sel punca mesenkim sangat cepat dan semarak. Banyak lab riset dan peneliti biomedik yang terjun ke area riset ini dan jumlahnya meningkat seiring dengan peningkatan jumlah publikasi dan aplikasi klinis terapi sel punca mesenkim. Fenomena ini di sisi lain menimbulkan dampak negatif yakni ambiguitas dan inkonsistensi hasil riset di bidang sel punca mesenkim.

 

SELENGKAPNYA…

 

 

Panduan Regulasi Selpunca India

 

 

 

Ditulis oleh dr. M. Adi Firmansyah   

 

Rabu, 15 Juli 2009 15:01

 

 

 

Setiap negara tentunya memiliki panduan tersendiri mengenai pemanfaatan sel punca. Salah satunya adalah India. Berikut adalah panduan regulasi selpunca yang berlaku di India.

 

Untuk informasi lebih lengkap, silahkan klik 

 

 

Stem Cell Regulation in India

, informasi dalam bentuk file pdf.

Anda dapat mengunduh file ini melalui menu Zona Unduh (pastikan Anda telah terdaftar sebagai member).

 

 

 

 

Peranan Endothelial Progenitor Cell(EPC) pada Neovaskularisasi

 

 

 

Ditulis oleh dr.Saut Nababan/dr.Okki, SpPD   

 

Rabu, 11 Agustus 2010 08:10

 

 

 

 

 

EPC merupakan sel-sel yang memiliki kemampuan untuk membelah dan berdiferensiasi menjadi sel-sel endotel. EPC merupakan bagian dari sel induk yang bersifat lebih matang dan unipoten. Secara klinis, EPC dapat memperbaiki kondisi-kondisi penyakit yang diawali dengan kerusakan sel-sel endotel, baik secara anatomis/struktural maupun fungsional, melalui mekanisme neovaskularisasi. Para peneliti menyakini bahwa di dalam sumsum tulang dan aliran darah tepi terdapat sel-sel yang mampu membelah dan berdiferensiasi menjadi sel-sel endotel dan memperbaiki jaringan iskemik akibat rusaknya dinding pembuluh darah. Sel-sel ini disebut endothelial progenitor cell atau EPC.

 

 

SELENGKAPNYA…

 

 

Transplantasi Autologus Sel Punca untuk Penyakit Autoimun: Hasil Sebuah Studi Cohort

 

 

 

Ditulis oleh dr Mulia , dr Okki SpPD   

 

Rabu, 14 April 2010 08:48

 

 

 

 

Penyakit autoimun yang mana diderita oleh 5-8% penduduk di dunia, menyumbangkan angka morbiditas jangka pendek maupun jangka panjang dan mortalitas yang bermakna. Meskipun terapi imunosupresan konvensional dan agen biologi baru dapat mengontrol penyakit autoimun berat, modalitas pengobatan ini jarang bersifat kuratif. Penyakit autoimun sistemik berat seperti multiple sclerosis (MS), systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis (JIA), hematologic immun cytopenia (HIC), dan penyakit Crohn sulit diobati; oleh karena itu, dibutuhkan strategi pengobatan lain. Sejak tahun 1996, transplantasi autologus sel punca telah dilakukan untuk pengobatan penyakit autoimun berat yang refrakter terhadap pengobatan konvensional.

 

SELENGKAPNYA…

 

 

Panduan Regulasi Terapi Sel Punca dari FDA

 

 

 

Ditulis oleh dr. M. Adi Firmansyah   

 

Sabtu, 18 Juli 2009 08:55

 

 

 

Perkembangan teknologi selpunca dan terapi berdasarkan sel punca dewasa ini kian marak. Hal ini mendorong FDA (

Food and Drug Administration) pada tahun 2006, mengeluarkan peraturan dan panduan mengenai terhadap produksi dan pemasaran terapi berbasis sel punca (stem-cell-based therapy). 

Klik pranala berikut untuk menyimak secara lengkap panduan dari FDA tersebut.

 

Regulasi FDA terhadap Terapi Berbasis Sel Punca

.

 

 

 

 

 

 

 

 

Artikel Lain…

 

Seminar sehari : Stem Cell Update; 8 Mei 2010Uji Klinis Implantasi Sel Punca Darah Perifer pada Infark Jantung, RSCM-FKUIKerjasama Pengembangan Sel Punca Iran-FKUI/RSCMPanduan Implementasi Klinis Sel PuncaBelajar dari Pengalaman Pusat Sel Punca BelandaKerjasama Stem Cell FKUI/RSCM dengan Leiden Medical CenterPertanyaan untuk Bahan TulisanPanduan Sel Punca untuk UmumTerapi Sel Punca pada Penyakit AutoimunRekomendasi Jasa Layanan Penyimpanan Darah Tali Pusat dari Royal College of Obstetrics & GynecologyUji Klinis Terapi Sel Punca pada Penyakit Arteri Perifer DM tipe-2Bahan Presentasi Simposium SelpuncaKunjungan Prof Dr. Willem Eduard Fibbe PhDSimposium Pengembangan Sel Punca FKUI/RSCM Sukses Digelar

 

 

 

 

 

 

 

 

 

 

 

 

 

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Dahlan Iskan biayai terapi “stemcell” Putu Wijaya

Jumat, 29 November 2013 22:53 WIB | 3479 Views

 

Menteri BUMN Dahlan Iskan (ANTARA FOTO/Dhoni Setiawan)

Jakarta (ANTARA News) – Menteri BUMN Dahlan Iskan membantu sastrawan Putu Wijaya yang menderita stroke dengan membiayai pengobatan melalui terapi “

stemcell“.

 

Siaran pers yang diterima ANTARA di Jakarta, Jumat, menyebutkan Dahlan yang pernah menjadi teman kerja Putu Wijaya di majalah “Tempo” menjenguk Putu di rumahnya di kawasan Ciputat, Tangerang Selatan.

Dahlan datang bersama seorang dokter ahli “stemcell” dari Surabaya yang dikenal sebagai ahli “stemcell” terbaik di Indonesia.

 

 

Kepada Putu, Dahlan yang menjadi penggemar cerita pendek dan novel Putu, menceritakan bahwa seseorang yang terserang stroke berpeluang disembuhkan kembali dengan terapi “stemcell“.

Dahlan sekaligus memperkenalkan dokter yang baru pulang mengajar “stemcell” di Tokyo dan Amsterdam itu. “Alhamdulillah, Mas Putu sangat antusias mengikuti diskusi dan menyatakan bersedia menjalani perawatan,” kata Dahlan melalui pesan pendek.

Dahlan mengatakan, biaya pengobatan dengan “stemcell” itu menjadi tanggungan pribadinya. “Harapan saya, semoga Tuhan memberikan kesembuhan kepada seniman besar kita ini,” kata Dahlan.

Putu Wijaya diketahui menderita serangan stroke awal Oktober lalu. Akibat stroke, seniman berusia 69 tahun itu tidak bisa berkarya lagi. Sejumlah kolega dan penggemarnya kemudian berinisiatif menggalang dana setelah membaca berita di media sosial bahwa Putu tidak mampu membayar biaya pengobatan.

 

 

Editor: Ruslan Burhani

KOMPAS.com – Many people with kidney failure , heart disease, diabetes , stroke , Parkinson’s cure is now helped by stem cell therapy or stem cell therapy .

Not only degenerative diseases , stem cell therapy can also heal skin problems such as acne , burns , until the problem of aging . Stem cell therapy is also powerful to overcome baldness .

This therapy is the latest medical technology that serves to regenerate cells in the body so it can recover and regrow damaged tissue .

Through two choices therapeutic procedure , ie injection and topical , stem cells derived from humans and processed in the laboratory will be entered into the patient’s body . Implant or implantation of stem cells into the patient’s body is carried out when stem cell processing laboratory results have been developed ( progenitor cells) or differentiated into cells expected .

 Then , stem cells are implanted in the patient’s body will grow and connect with the body’s cells to repair systems and cell regeneration .

” By engineering biology , stem cells can alter other body cells , the damaged bone , skin destroyed , to be normal again , in addition to the cell will continue to improve, ”

said stem cell therapy expert , Dr. Indah Julianto , in launching a new breakthrough in stem cell Women’s and Children ‘s Hospital UB , Jakarta , Saturday ( 09/21/2013 ) .

Source of stem cells
Beautiful dr therapy practiced using stem cells from human sources , mainly from umbilical cord blood and umbilical cord Wharton’s jelly . According to Dr. Beautiful , stem cells derived from baby to have the best quality . In applying the therapy , he also uses a source of stem cells from the placenta , not the embryo .

” Immature cells are not known viruses or bacteria . Umbilical cord was never infected with the virus , ” he said .

Dr. Beautiful explains , stem cells derived from the placenta is the source of about 8-10 human stem cells that have been clinically proven through laboratory research . In addition to the placenta , other sources of human stem cells derived from fat , hair , skin , arteries , veins , and others .

Human stem cells , he explained , has 8,000 times the power of its antibiotic and anti – inflammatory . ” Stem cells that miracle . Were no side effects because it is not a drug and not chemicals , ” said Dr. Lovely .

To get optimum benefit from stem cell therapy , stem cells need to be considered quality .

 According to Dr. Beautiful , types of stem cells from the umbilical cord can last only 36 hours .

While stem cells derived from umbilical cord Wharton’s jelly after 48 hours can not function .

” Every 30 minutes , the ability of the cells decreased one percent , ” he said .

Using stem cells that supply is available in UNS Solo , stem cell therapy will take can not be beaten flat .

The duration of therapy depends illness . In patients who experience problems with hair growth , within four months after the treatment , the hair on the head began to grow heavy . Dr. Beautiful using injection and topical procedures to address these issues . As for acne , the treatment is carried out for one month and topically .

However , indeed , for certain diseases , stem cell therapy could take longer.

Dr. Lovely said , people with kidney failure requiring the longest time to undergo this therapy .

” It took about 18 times injection for renal disease , ” he said .

Other diseases that have the potential to improve with stem cell therapy among autism , lupus , epilepsy , blood disorders ( hematopatology ) , autoimmune diseases, multiple sclerosis , Alzheimer’s , and a number of other diseases .

Types of diseases that affect the number of stem cell use ( injection / topical ) will determine how much money is needed for therapy . Per 1 cc of stem cells can cost about Rp 3 million . Once syringes cost about Rp 6 million .

editor :
Asep Candra

KOMPAS.com — Banyak penderita gagal ginjal, jantung, diabetes, stroke, parkinson yang penyembuhannya kini terbantu dengan terapi stem cells atau terapi sel punca.

 

Bukan hanya penyakit degeneratif, terapi sel punca juga dapat menyembuhkan masalah kulit seperti jerawat, luka bakar, hingga masalah penuaan. Terapi sel punca juga ampuh mengatasi kebotakan.

Terapi ini merupakan teknologi kedokteran terkini yang berfungsi meregenerasi sel dalam tubuh sehingga dapat memulihkan dan menumbuhkan kembali jaringan yang rusak.

Lewat dua pilihan prosedur terapi, yakni injeksi dan topikal, sel punca yang bersumber dari manusia dan diproses di laboratorium ini akan masuk ke tubuh pasien. Implan atau penanaman sel punca ke tubuh pasien ini dilakukan bila sel punca hasil pemrosesan di laboratorium sudah berkembang (progenitor cell) atau berdeferensiasi menjadi sel yang diharapkan.

 

Kemudian, sel punca yang ditanamkan di tubuh pasien ini akan berkembang dan berkoneksi dengan sel tubuh untuk melakukan perbaikan sistem dan regenerasi sel.

“Dengan rekayasa biologi, sel punca dapat mengubah sel tubuh lain, tulang yang rusak, kulit hancur, menjadi normal kembali, di samping sel akan terus memperbaiki diri,”

 

ungkap ahli terapi sel punca, dr Indah Julianto, dalam launching terobosan baru sel punca di Rumah Sakit Ibu dan Anak Brawijaya, Jakarta, Sabtu (21/9/2013).

 

 

 

 

 

 

 

Sumber sel punca
Terapi yang dipraktikkan dr Indah menggunakan sumber sel punca dari manusia, utamanya darah dari tali pusat dan jelly wharton tali pusat. Menurut dr Indah, sel punca yang bersumber dari bayi memiliki kualitas terbaik. Dalam mengaplikasikan terapi, ia juga menggunakan sumber sel punca dari plasenta, bukan embrio.

Sel immature tidak kenal virus atau kuman. Tali pusat tidak pernah terinfeksi virus,” ungkapnya.

Dr Indah menjelaskan, sel punca bersumber dari plasenta merupakan satu dari sekitar 8-10 sumber human stem cells yang telah teruji klinis melalui penelitian di laboratorium. Selain plasenta, sumber stem cells manusia lainnya berasal dari lemak, rambut, kulit, arteri, vena, dan lainnya.

Human stem cells, jelasnya, memiliki 8.000 kali kekuatan antibiotiknya dan anti-inflamasi. “Stem cells itu miracle. Tidak ada efek samping karena bukan obat dan bukan bahan kimia,” jelas dr Indah.

Untuk mendapatkan manfaat optimal dari terapi stem cells, kualitas stem cells perlu diperhatikan.

 

 

 

Menurut dr Indah, tipe stem cells dari tali pusat hanya bisa bertahan 36 jam.

 

 

 

Sementara sel punca yang berasal dari jeli wharton tali pusat setelah 48 jam tidak bisa berfungsi.

“Setiap 30 menit, kemampuan sel menurun satu persen,” ungkapnya.

Menggunakan sel punca yang pasokannya tersedia di UNS Solo, terapi stem cells akan memakan waktu yang tak bisa dipukul rata.

 

 

 

 

 

 

 

Durasi terapi ini bergantung penyakit yang diderita. Pada pasien yang mengalami masalah pada pertumbuhan rambut, dalam waktu empat bulan setelah terapi, rambut di kepala mulai tumbuh lebat. Dr Indah menggunakan prosedur injeksi dan topikal untuk mengatasi masalah ini. Sementara untuk mengatasi jerawat, terapi ini cukup dilakukan selama satu bulan dan secara topikal.

Namun, memang, untuk penyakit tertentu, terapi stem cells bisa memakan waktu lebih lama.

 

 

 

 

Dr Indah menyebutkan, penderita gagal ginjal membutuhkan waktu paling lama untuk menjalani terapi ini.

“Butuh sekitar 18 kali injeksi untuk penyakit gagal ginjal,” ungkapnya

 

.

Penyakit lain yang berpotensi membaik dengan terapi sel punca di antaranya autisme, lupus, epilepsi, penyakit gangguan darah (hematopatology), autoimun, multiple sclerosis, alzheimer, dan sejumlah penyakit lainnya.

Jenis penyakit yang memengaruhi jumlah penggunaan sel punca (suntik/topikal) akan menentukan berapa biaya yang dibutuhkan selama terapi. Per 1 cc sel punca biayanya mencapai Rp 3 juta. Sekali suntik biayanya sekitar Rp  6 juta.

 

 

Editor :

 

Asep Candra

 

 

 

 

 

 

SOME disease has been known to be cured by stem cell therapy , such as heart disease , stroke , and even cancer . So how about the stages of treatment of stem cell therapy ?

According to dr . Her Yudi Oktaviono , Sp.JP ( K ) , to process autologous stem cell therapy is that the source is not derived from umbilical cord blood , treatment episodes starting from a thorough examination of the patient’s condition .

” When patients eligible for stem cell therapy , the patient will have blood drawn for her then purified stem cells , ” said dr . Yudi in the seminar ” New Hope Treatment of Disease with Stem Cell Regenerative Therapy through ” in Prodia Tower Auditorium , Central Jakarta , Tuesday ( 03/12/2013 ) .

Furthermore , dr . Yudi explains that the stem cells will be cultivated in the laboratory .
Then , the stem cells are cultivated will continue with the process of cryogenic storage ( low temperature to -196 ° C ) .

” Or it can also be used directly by injection or intravenously its stem cells into the patient’s body , ” he continued .

Meanwhile , in the process of developing stem cell dr . Yudi said that it should also pay attention to sterility and engineering in the work environment . The processing of stem cells , ranging from separation until breeding facilities must be done in accordance with cGMP standards .

For therapeutic purposes , dr . Yudi said that the stem cells will be bred to reach sufficient numbers before being transplanted into the patient .
 In addition , any pengembangbiakannya period varies depending on the type of stem cell that is expected .

” For hematopoietic stem cell takes about 4-5 days , whereas for mesenchymal stem cells reach the incubation period of 4-5 weeks , ” he explained . ( tty )
INILAH.COM , Jakarta – been growing since 1998 , but has yet to bloom or stem cell treatment stem cells in Indonesia .
 Reportedly , no berkembangannya stem cell , because the cost is mahal.d

Beautiful doctor Yulianto Professor of Dermatology Association and the University of March Venerologi admit , in Indonesia the use of stem cells has not been well developed .
 In addition to the lack of regulations , costly problems also be a factor.

” Regulations have not been there , here no one would be examined because it is too difficult and expensive , while they asked him cheap , it’s a hassle , ” said Indah which is also Principal Researcher Dermama Biotechnology Laboratory , at Brawijaya Women & Children Hospital , Jakarta , new – recently.

Stem cell therapy is the latest medical technologies that harness stem cells to regenerate cells in the body so it can recover and regrow body tissue damaged by degenerative diseases .

Beautiful confirms continuing to develop the use of stem cells derived from umbilical cord blood and umbilical cord Wharton’s Jelly with holding four hospitals in Indonesia : Jakarta UB Women Children Hospital , Muwardi RS and RS PKU Muhammadiyah Solo and Mayapada Hospital in Tangerang .

” Because these stem cells is a form of healing that is created directly from the power , I do not want anyone to inhibit this , ” said Belle eagerly .

Beautifully explained , stem cell processing to mnjadi treatment requires lengthy and expensive process . ” Stem cells obtained will be processed in the laboratory and then berdeferensi be expected cell .
It will be an implant or implantation of stem cells into the patient’s body which will further evolve and connect with the body’s cells and perform system repair and regeneration of cells , “said Lovely ..
So far , the disease can be cured with stem cells : the complications of diabetes mellitus , epilepsy , Parkinson’s , heart disease, paralysis , Alzheimer , stroke .
 Stem cells can also treat autism , cerebral palsey and others .
Stem cells also can be used for beauty treatments and skin diseases such as pigmentation , acne and baldness cases . [ aji ]
Many people with kidney failure , heart disease, diabetes , stroke , Parkinson’s cure is now helped by stem cell therapy or stem cell therapy .

Not only degenerative diseases , stem cell therapy can also heal skin problems such as acne , burns , until the problem of aging . Stem cell therapy is also powerful to overcome baldness .

This therapy is the latest medical technology that serves to regenerate cells in the body so it can recover and regrow damaged tissue .

Through two choices therapeutic procedure , ie injection and topical , stem cells derived from humans and processed in the laboratory will be entered into the patient’s body . Implant or implantation of stem cells into the patient’s body is carried out when stem cell processing laboratory results have been developed ( progenitor cells) or differentiated into cells expected .

 Then , stem cells are implanted in the patient’s body will grow and connect with the body’s cells to repair systems and cell regeneration .

” By engineering biology , stem cells can alter other body cells , the damaged bone , skin destroyed , to be normal again , in addition to the cell will continue to improve, ”

said stem cell therapy expert , Dr. Indah Julianto , in launching a new breakthrough in stem cell Women’s and Children ‘s Hospital UB , Jakarta , Saturday ( 09/21/2013 ) .

Source of stem cells
Beautiful dr therapy practiced using stem cells from human sources , mainly from umbilical cord blood and umbilical cord Wharton’s jelly . According to Dr. Beautiful , stem cells derived from baby to have the best quality . In applying the therapy , he also uses a source of stem cells from the placenta , not the embryo .

” Immature cells are not known viruses or bacteria . Umbilical cord was never infected with the virus , ” he said .

Dr. Beautiful explains , stem cells derived from the placenta is the source of about 8-10 human stem cells that have been clinically proven through laboratory research . In addition to the placenta , other sources of human stem cells derived from fat , hair , skin , arteries , veins , and others .

Human stem cells , he explained , has 8,000 times the power of its antibiotic and anti – inflammatory . ” Stem cells that miracle . Were no side effects because it is not a drug and not chemicals , ” said Dr. Lovely .

To get optimum benefit from stem cell therapy , stem cells need to be considered quality .

 According to Dr. Beautiful , types of stem cells from the umbilical cord can last only 36 hours .

While stem cells derived from umbilical cord Wharton’s jelly after 48 hours can not function .

” Every 30 minutes , the ability of the cells decreased one percent , ” he said .

Using stem cells that supply is available in UNS Solo , stem cell therapy will take can not be beaten flat .

The duration of therapy depends illness . for certain diseases , stem cell therapy could take longer.

Dr. Lovely said , people with kidney failure requiring the longest time to undergo this therapy . ” It took about 18 times injection for kidney disease , ”

 

BEBERAPA penyakit telah diketahui dapat disembuhkan dengan terapi stem cell, seperti penyakit jantung, stroke, bahkan kanker. Lantas bagaimana tahapan pengobatan dari terapi stem cell?

Menurut dr. Yudi Her Oktaviono, Sp.JP(K), untuk proses terapi stem cell secara autologous yang sumbernya bukan berasal dari darah tali pusat, tahapan pengobatan dimulai dari pemeriksaan kondisi pasien secara menyeluruh.

“Apabila pasien memenuhi syarat untuk menjalani terapi stem cell, pasien akan diambil darahnya untuk kemudian stem cell-nya dimurnikan,”jelas dr. Yudi dalam seminar “Harapan Baru Pengobatan Penyakit dengan Stem Cell melalui Terapi Regeneratif” di Auditorium Prodia Tower, Jakarta Pusat, Selasa (3/12/2013).

Selanjutnya, dr. Yudi menjelaskan bahwa stem cell tersebut akan dikembangbiakkan di laboratorium.

Kemudian, stem cell yang dikembangbiakkan tersebut akan dilanjutkan dengan proses penyimpanan kriogenik (suhu rendah sampai -196 °C).

“Atau dapat juga langsung digunakan melalui penyuntikan atau diinfus stem cell-nya ke dalam tubuh pasien,”lanjutnya.

Sementara, dalam proses pengembangan stem cell dr. Yudi mengatakan bahwa itu juga harus memperhatikan kesterilan lingkungan dan teknik dalam bekerja. Proses pengolahan stem cell, mulai dari pemisahan sampai pengembangbiakan harus dilakukan dalam fasilitas yang sesuai dengan standar cGMP.

Untuk keperluan terapi, dr. Yudi mengatakan bahwa stem cell akan dikembangbiakkan hingga mencapai jumlah yang cukup sebelum ditransplantasikan ke tubuh pasien.

Selain itu, masa pengembangbiakannya pun bervariasi tergantung dari jenis stem cell yang diharapkan.

“Untuk stem cell hematopoitik dibutuhkan waktu sekitar 4-5 hari, sedangkan untuk stem cell mesenkimal masa inkubasinya mencapai 4-5 minggu,”terangnya. (tty)

INILAH.COM, Jakarta – Sudah berkembang sejak 1998, namun belum marak pengobatan stem cell atau sel punca di Indonesia.

Kabarnya, tak berkembangannya stem cell, karena biayanya yang mahal.d

 

Dokter Indah Yulianto dari Assosiasi Profesor Dermatologi dan Venerologi Universitas Sebelas Maret mengakui, di Indonesia penggunaan stem cell belum berkembang baik.

Selain belum adanya peraturan, masalah biaya yang mahal juga menjadi faktor penyebab.

“Peraturan belum ada, di sini belum ada yang mau meneliti karena ini terlalu sulit dan mahal, sementara mereka mintanya murah, ini kan repot,” kata Indah yang juga Principal Researcher Laboratorium Bioteknologi Dermama, di Brawijaya Women & Children Hospital, Jakarta, baru-baru ini.

Terapi stem cells merupakan teknologi kedokteran terkini yang memanfaatkan sel punca untuk meregenerasi sel dalam tubuh sehingga dapat memulihkan dan menumbuhkan kembali jaringan sel tubuh yang rusak akibat berbagai penyakit degeneratif.

 

Indah menegaskan terus mengembangkan penggunaan stem cell yang berasal dari darah tali pusat dan Wharton Jelly tali pusat dengan menggandeng empat rumah sakit di Indonesia: Brawijaya Women Children Hospital Jakarta, RS Muwardi dan RS PKU Muhammadiyah Solo dan Rumah Sakit Mayapada Tangerang.

“Karena stem cell ini adalah bentuk penyembuhan yang diciptakan langsung dari yang kuasa, saya tidak mau ada yang menghambat ini,” ujar Indah bersemangat.

Indah menjelaskan, pengolahan stem cell hingga mnjadi pengobatan memerlukan proses panjang dan mahal. “Stem cells yang diperoleh akan diproses di laboratorium kemudian berdeferensi menjadi sel yang diharapkan.

Maka akan dilakukan implan atau penanaman stem cells tersebut ke dalam tubuh pasien yang selanjutnya akan berkembang dan berkoneksi dengan sel-sel tubuh serta melakukan perbaikan sistem dan regenerasi sel,” terang Indah..

Sejauh ini, penyakit bisa sembuh dengan stem cells: diabetes melitus dengan komplikasi, epilepsi, parkinson, jantung, kelumpuhan, alzeimer, stroke.

Stem cell juga bisa mengobati autisme, cerebal palsy dan lainnya.

Stem cell juga bisa untuk perawatan kecantikan dan penyakit kulit seperti pigmentasi, jerawat dan kasus kebotakan. [aji]

Banyak penderita gagal ginjal, jantung, diabetes, stroke, parkinson yang penyembuhannya kini terbantu dengan terapi stem cells atau terapi sel punca.

 

Bukan hanya penyakit degeneratif, terapi sel punca juga dapat menyembuhkan masalah kulit seperti jerawat, luka bakar, hingga masalah penuaan. Terapi sel punca juga ampuh mengatasi kebotakan.

Terapi ini merupakan teknologi kedokteran terkini yang berfungsi meregenerasi sel dalam tubuh sehingga dapat memulihkan dan menumbuhkan kembali jaringan yang rusak.

Lewat dua pilihan prosedur terapi, yakni injeksi dan topikal, sel punca yang bersumber dari manusia dan diproses di laboratorium ini akan masuk ke tubuh pasien. Implan atau penanaman sel punca ke tubuh pasien ini dilakukan bila sel punca hasil pemrosesan di laboratorium sudah berkembang (progenitor cell) atau berdeferensiasi menjadi sel yang diharapkan.

 

Kemudian, sel punca yang ditanamkan di tubuh pasien ini akan berkembang dan berkoneksi dengan sel tubuh untuk melakukan perbaikan sistem dan regenerasi sel.

“Dengan rekayasa biologi, sel punca dapat mengubah sel tubuh lain, tulang yang rusak, kulit hancur, menjadi normal kembali, di samping sel akan terus memperbaiki diri,”

 

ungkap ahli terapi sel punca, dr Indah Julianto, dalam launching terobosan baru sel punca di Rumah Sakit Ibu dan Anak Brawijaya, Jakarta, Sabtu (21/9/2013).

 

 

 

 

 

 

 

Sumber sel punca
Terapi yang dipraktikkan dr Indah menggunakan sumber sel punca dari manusia, utamanya darah dari tali pusat dan jelly wharton tali pusat. Menurut dr Indah, sel punca yang bersumber dari bayi memiliki kualitas terbaik. Dalam mengaplikasikan terapi, ia juga menggunakan sumber sel punca dari plasenta, bukan embrio.

Sel immature tidak kenal virus atau kuman. Tali pusat tidak pernah terinfeksi virus,” ungkapnya.

Dr Indah menjelaskan, sel punca bersumber dari plasenta merupakan satu dari sekitar 8-10 sumber human stem cells yang telah teruji klinis melalui penelitian di laboratorium. Selain plasenta, sumber stem cells manusia lainnya berasal dari lemak, rambut, kulit, arteri, vena, dan lainnya.

Human stem cells, jelasnya, memiliki 8.000 kali kekuatan antibiotiknya dan anti-inflamasi. “Stem cells itu miracle. Tidak ada efek samping karena bukan obat dan bukan bahan kimia,” jelas dr Indah.

Untuk mendapatkan manfaat optimal dari terapi stem cells, kualitas stem cells perlu diperhatikan.

 

 

 

Menurut dr Indah, tipe stem cells dari tali pusat hanya bisa bertahan 36 jam.

 

 

 

Sementara sel punca yang berasal dari jeli wharton tali pusat setelah 48 jam tidak bisa berfungsi.

“Setiap 30 menit, kemampuan sel menurun satu persen,” ungkapnya.

Menggunakan sel punca yang pasokannya tersedia di UNS Solo, terapi stem cells akan memakan waktu yang tak bisa dipukul rata.

Durasi terapi ini bergantung penyakit yang diderita. untuk penyakit tertentu, terapi stem cells bisa memakan waktu lebih lama.

 Dr Indah menyebutkan, penderita gagal ginjal membutuhkan waktu paling lama untuk menjalani terapi ini. “Butuh sekitar 18 kali injeksi untuk penyakit gagal ginjal,”

Driwan Stem Cell Therapy Information Center (continiu)

 

 

FOUNDER
 
Dr Iwan Suwandy,MHA
more infocontact
iwansuwandygmail.com
all free of charge
this info to all human in the world
with
 
THE MIGHTY GOD BLESS
 

International Hospital Yogyakarta

 Indonesia establish cooperation >>>

President Adi Husada hospital Indonesia, Guo Shao Lin and his wife received an invitation to visit the Cave
Joy Tobing do Anti-Aging in Modern Hospital Guangzhou (Stem Cell Research and Treatment Center >>>

Rumah Sakit Internasional Yogyakarta Indonesia membangun kerjasama >>>

 

Presiden rumah sakit Adi Husada Indonesia, Guo Shao Lin dan istri mendapat undangan berkunjung ke Gua

Joy Tobing melakukan Anti-Aging di Modern Hospital Guangzhou (Stem Cell Research and Treatment Center >>>

 

  • Sistm promosi pusat terapi stem cell guangzhao ini sangat cangih, tetapi tidak pernah menyeduakan info tentang berapa biaya terapi ini dan evaluasi hasil terapi secara patologis dan scanning serta pemeriksaan laboratorium lainnya sebelum dan sesudah terapi juga tidak tersedia seperti bagainan a perbaikan fungsi ginjal dengan  hasil pemeriksaan CCT pada urin 24 jam khususnya ekresi protei urine dan creatine serum sebagai alat penilai adanya kebocoran dari glomeruli ginjal.Namun stem terapi ini sangat menjanjikan dan perlu para ahli Indonesia dikirim ke pusat stem cell ini untuk belajar dan kemudian mengembangkannya di Indonesia.catatan Dr Iwan

 

 

 

 

 

Two professional chief physicians instruct the Internal Medicine Department (IMD). They use stem cell technology to treat many kinds of the complicated diseases that the IMD specialize in such as diabetes (type1,type2), apituitarism disease, hypothyroidism disease, idiopathic sarcoidosis, osteoporosis (embrace Perthes’ disease), rheumatoid arthritis , ankylosing spondylitis , systemic lupus erythematosus, vasculitis , sicca syndrome and so on.

 

They have treated about 300 patients successfully. The treatment is safe and reliable, the results are remarkable. The outcomes have significantly improved the patients’ quality of life.

 

Diabetes is a metabolic disorder which is the cause of many kinds of other diseases. Its main characteristic is chronic hyperglycemia. There are two reasons that cause the blood sugar levels to heighten. One is insulin secretion and the other is function flaw, another reason is that both conditions may exist. Diabetes is divides into type 1, type 2, and other special types, including gestational diabetes and so on.

 

With people’s living conditions improving, and as a result, life expectancy increasing worldwide, according to a WHO report, in 1997, there were about 135 millions diabetics in the world and this number is expected to rise to 300 millions by 2025.

 

Stem cell therapy is a new method; it was developed with molecular biology, molecular immunology and cell biology. It can treat diabetes from the cell and the gene level and cure diabetes on the clinical. It has minor side effects. The merits are the minor side effects and the steadying of the blood sugar levels. The effect is good.

 

 

 

We use self activation of the island Langerhans’ stem cell and stem cell transplantation to cure diabetes.

 

The types of transplantation cells are embryo stem cells, the insulin type of cell which originates in the embryo and develops into bone mesenchymal stem cells.

 

 

adma Shri Dr. V. Mohan is an eminent Indian Diabetologist who has been working in the field of diabetes for over 30 years in Chennai in southern India. Dr. Mohan is the Chairman and Chief of Diabetology at Dr. Mohan’s Diabetes Specialities Centre, a WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control and an IDF Centre of Education.

 He is also President and Director of

 the Madras Diabetes Research Foundation.

Dr. Mohan completed his undergraduate (MBBS) and postgraduate medical education (MD, General Medicine) from Madras Medical College, Chennai, India. He then worked for a year as a Wellcome Trust Research Fellow at the Royal Postgraduate Medical School and Hammersmith Hospital, London, U.K and later for a year as an Alexander Von Humboldt Fellow at the University of Ulm, West Germany

 He was awarded a Ph.D.

and later a Doctor of Science (D.Sc.)

for his research on diabetes.

Prof. Mohan’s activities cover a wide range of clinical services, training and education, rural diabetes services and charity, research and public education and other activities on diabetes which are outlined below.

Dr. Mohan started working on diabetes as an undergraduate medical student when he joined his father late Prof. M. Viswanathan a pioneer in diabetes in India.

Together with his father, Dr. Mohan set up the first private diabetes centre in India in 1971 and continued to work at this centre till 1991. Dr. Mohan and his late wife Dr. Rema Mohan subsequently established their own diabetes centres under the name of

“Dr. Mohan’s Diabetes Specialities Centre”. 

Dr. Mohan and his colleagues currently oversee 13 diabetes centres and clinics in southern India and over 300,000 diabetic patients have been registered at these centres.

In 1996, Dr. Mohan established the Madras Diabetes Research Foundation (MDRF) in Asia. His research combines clinical, epidemiological and genomic aspects of diabetes. He has published nearly 834 papers including over 516 original research articles in peer reviewed journals, over 120 chapters in text books on diabetes, endocrinology and Internal Medicine and several invited reviews and editorials.

Dr. Mohan has received numerous awards and Fellowships. These includes the Padma Shri National Award by the Govt. of India for his accomplishments in the field of diabetology, Dr. BC Roy Award from the Medical Council of India and the Basanti Devi Amir Chand Prize from the Indian Council of Medical Research. Dr. Mohan was also awarded the Fellowships of the Wellcome Trust, UK and the Alexander Von Humboldt Foundation, Germany. He also received the Wockhardt Award for Medical Excellence from the Harvard Medical International, Boston. Dr. Mohan has been conferred Fellowships by all the four Royal Colleges of Physicians of London, Edinburgh, Glasgow and Ireland. He has also been elected Fellow of the National Academy of Sciences (FNASc).

Dr. Mohan’s work has been recognized by the World Health Organization (WHO) which has nominated his centre as a “WHO Collaborating Centre for Prevention and Control of Non-Communicable Diseases” as well as by the International Diabetes Federation (IDF) which nominated his centre as an “IDF Centre of Education”. He also serves on the Steering Committee of the Govt. of India’s National Program for Prevention and Control of Diabetes, Cardiovascular Diseases and Stroke (NPDCS) and on several other national scientific organizations. He is also a WHO Consultant on Diabetes and serves on several committees of the International Diabetes Federation.

 

Dr. V. Mohan receiving the Prestigious Padma Shri Award

 

 

 

 

 

 

 

 

 

 

 

Chennai: The Haven of Medical Research

Chennai has become the hotbed for breakthrough medical research work, thus attracting international collaborations, informs Nayantara Som.

Academicians in Hyderabad and Bangalore have competition now. There is another promising contestant in the race. Hitherto, Chennai was mainly associated with medical tourism, mushrooming hospitals and regular influx of patients. This is all passé. Now, the city seems to have gone through a metamorphosis. Today, walk into any hospital and, it is a common feature to see a separate research institute or a medical college attached, where intensive research work is deliberated upon and published.

“In diabetes, out of all Indian publications, around 40-50 per cent comes from Chennai”

 

– Dr V Mohan
Chairman
Dr Mohan’s Diabetes
Specialities Centre

Stem cell research, tissue engineering, molecular biology, nanotechnology, clinical and epidemiological studies, gene therapy, research in diabetes, you name it and Chennai has it all.

In diabetes alone, experts assert there is no competitor. Dr V Mohan, Chairman, Dr Mohan’s Diabetes Specialities Centre and President and Director of Madras Diabetes Research Foundation, Chennai, says,

“Chennai is definitely on the world map of medical research. In diabetes alone, if you browse through all the Indian publications, around 40-50 per cent comes from Chennai alone!”

 Prestigious institutes in the city like the Tuberculosis Research Centre, the Cancer Institute and the Madras Diabetes Research Foundation have come up with pioneering studies, making Chennai the locus of all research studies. Dr Sanjay Cherian, Managing Director, Frontier Lifeline, Chennai, says, “Chennai has a huge pool of experts and at the same time there is a large number of medical colleges growing rapidly.”

Collaborations with prestigious institutes abroad and in the country is a continuous process. Dr Samuel Abraham, Director, Nichi Centre for Regenerative Medicine (NCRM), Chennai, elaborates, “In Chennai, there are 14 or more institutes working on basic research and clinical applications of stem cell, which is the largest in any metro in the country, not only in number but also in diverse areas of the speciality.”

Research at some of the Hospitals

Frontier Lifeline

Its special unit, TICEL Bio Park is undertaking advanced research in Tissue Engineering

Sankara Nethralaya

Sankara Nethralaya is conducting research in nanotechnology for ophthalmology

MDRF, Chennai

The Madras Diabetes Research Foundation is specialising in genomics, clinical trials and vascular biology

NCRM, Chennai

NCRM is involved in the Chondrocytes for articular cartilage defect, Retinitis Pigmentosa, Cytotoxic T-Lymphocytes for Cancer and HIV, along with Biotherapy Institute, Japan

emodin inhibits 11β-HSD1 activity in 3T3-L1 adipocytes and improves inactive glucocorticoid-induced adipocyte dysfunction.

Diabetes

Stem Cell Research

Stem cell research is another prime area of focus for Chennai. “Research on cardiovascular diseases is ongoing by our genetic engineering lab,” says Dr Guhathakuta.

 In basic research, a project on bone marrow transplant is underway and is partly funded by the ICMR.

The Phase I trial with bone marrow derived stem cells with conditioning media is currently underway at the research facility at TICEL Bio Park.

In Phase II, progenitor cells harvested from blood and entirely autologous are the best cells available and ready for clinical use.

A technique is adopted whereby an injection (GcSF) is given for three days and subsequently the mononuclear stem cells are isolated by aphaeresis technique.

These cells are injected during surgery into the myocardium in the cardiac catheterisation laboratory.

 

This was performed in collaboration with Sri Venkateswara Institute of Medical Sciences, Tirupati. “This procedure has been performed in eight patients and another 20 patients are waiting,” says Dr S Cherian.

“The stem cells are separated and grown in Israel and used in Bangkok. There are more than 100 people waiting for this treatment. The cost in Bangkok for each patient is around $34,000 (including hospital stay).

In India, we could do it for $5,000,”says Dr KM Cherian.

Another project to look forward to is the Bio-Sciences Park, within the proposed Medicity, spearheaded by Frontier Lifeline, which will harbour a unit specially for R&D. Plans are on the anvil in which expert training, in the field of tissue engineering, for the whole of South East Asia will commence.

Again Sankara Nethralaya is involved in stem cell research like corneal limbal cell research.

If limbal stem cells are affected due to conditions such as acid or alkali burns, Steven Johnson syndrome etc, corneal grafting usually fails.

By transplanting limbal cells the success of grafting can be significantly improved.

 The practice has been to grow limbal stem cells on amniotic membranes.

Dr H N Madhavan, Director of research at Sankara Nethralaya was able to grow these limbal cells on a polymer (mebiol gel) in association with Dr Abraham from Japan.

We have been involved in this study since 2002 and after the animal experimentation which was completed, we are awaiting ICMR approval for the human trials.

 

The NCRM, Chennai (a Japanese collaboration) is collaborating with Sankara Netharalaya for this project.

The unique advantage here is there no usage of animal tissue or human tissue and so no possibility of rejection.

Cells are to be taken from patients’ own normal eye or normal portion of the affected eye.

One scientist is undergoing training for a year from an expert specialising in neuro stem cells.

There is research ongoing in neuro stem cells. Attempts are being made to convert a particular stem cell into a retinal nerve cell. “That, of course, is going to take decades before it can be introduced,” adds Dr Gopal.

Sankara Netharalaya has put in place multiple partnerships for research. Broad based MoUs have been inked with LV Prasad Eye Institute in Hyderabad and Aravind Eye Clinic, Madurai. “We are at a stage where we can bring together all our resources for better work,” says Dr Gopal. Other than broad-based agreements, there are individual-based agreements. The institute conducts drug trials for companies, with scientists from the US, New Zealand and Japan.

In technology,a recent acquisition is the Affymetrix machine, a state-of-art technology that does genetic analysis. Millions of genes can be looked and tested in one shot. An analysis that would take one year to identify the gene, will now take few days.

NCRM is also working on Corneal Endothelial Precursor Cells in collaboration with Tokyo University School of Medicine, who gave the technology and specimens and the harvesting was accomplished by Joseph Eye Hospital, Trichy.

This project is at the lab level and aims at treating bullous keratopathy, a disease that affects a lakh patients, each year. It affects the inner layer of the cornea, for which total corneal transplant is an option now. “By our technology, we have to take a few hundred cells from cadaver corneal endothelium (inner layer) and expand it to be put in the respective portion for cure, by doing which, the inner layer of cells of cornea of one cadaver eye can help recover the vision of a minimum of 40-60 people.”

Hurdles Faced

“Bangalore and Hyderabad boast of some of the best institutes in the country and the government allocates large amounts of money for infrastructure and development of these institutes. Chennai does not have such institutes and hence the opportunity for multisectoral research are less than Bangalore or Hyderabad,” says Dr Mohan who is also the President of the Madras Science Foundation. He, however, feels that there is enough funds available from various government agencies like ICMR, DBT, DST and CSIR.

“We need more money for medical research in India. It is currently difficult to get funds for medical research in our country. Similar to the situation in US and UK more organisations should donate money for medical research,” says Dr Viswanathan.

The Road Ahead

There are other experts in the city who beg to differ and are firm on their stand that Chennai rules the roost. Says Dr Abraham, “Though several prominent central government research institutes are present in Hyderabad and Bangalore (CCMB, IISc, NIMHANS), the gap between clinical faculty and basic sciences is too large in India. When an initiative is taken from clinical side the results are faster and better. This is where Chennai wins.”

The future is bright for Chennaites. “There is a lot in store for stem cell research. There is going to be stem cell research in plastic surgery, in orthopaedics and for cardio-vascular diseases,” says Dr S Cherian. In cases like diabetic ulcers and where a body part has to be amputated, stem cell therapy is a solution to free patients from this nightmare. Moreover in diabetes, large scale studies are on like the primary prevention programmes and awareness programmes. Experts also predict the coming together of biotechnological and pharmaceutical companies with the medical profession.

“A few partnerships are happening. The city is seeing and will see clinical trials, genetics, advances in insulin and vaccines and above all the why’s and how’s of diabetes,” says Dr Viswanathan.

 

 

 The Tuberculosis Research Centre is patenting a drug for HIV/AIDS. Construction of a new research facility of MDRF at SIRUSERI in the outskirts of Chennai is now nearing completion and is slated for inauguration in 2-3 months. This project will take the research at MDRF to the next level of basic research involving proteomics, tissue culture, stem cells and development of gene chips for accurate genomic classification of different subtypes of diabetes. As far as funding is concerned, institutes are concerned about solutions rather than whining about paucity. Collaborations both within and outside the country is a huge source for bringing in money. We sometime donate our own personal funds for conducting research projects.” says Dr. Viswanathan. “Sometimes hospital donate their own profits for the research projects,” adds Dr Viswanathan.

An optimistic approach is shared by a majority of experts from the city and perhaps it will be this approach which can keep Chennai ahead in the rat race.

nayantara.som@expressindia.com

 

Prof. John E. Rasko: Stem cell therapies at a crossroad

“Worldwide stem cell gene therapies are at a crossroad,” said Prof. Dr. John E. Rasko after the Universiti Tunku Abdul Rahman (UTAR) Seminar on Recent Advances in Stem Cell Research held at UTAR Sungai Long Campus on 25 May 2013.

Prof. Rasko, clinical hematologist, pathologist and scientist, is an Australian pioneer in the application of adult stem cell and genetic therapy.

  He directs the Department of Cell and Molecular Therapies at Royal Prince Alfred Hospital and heads the Gene and Stem Cell Therapy Programme at the Centenary Institute, University of Sydney. 

 He is the recipient of many national and international awards in recognition of his commitment to excellence in medical research, including appointment as an Officer of the Order of Australia.

 

“Stem cell therapy is at a crossroad of promises of new treatments versus unproven therapies,” Prof. Rasko elaborated, adding that many of these promises have turned to be false hopes for the people affected.

 In his two lectures, he said repeatedly that progress in stem cell therapy had always been ‘three steps forwards and two steps back’.

The situation is the same in Malaysia, where he said research in stem cells has generally been progressing well. 

While stem cell treatments are usually costly, unproven protocols bring no benefits and may even cause harm.

“As in many other countries, strict regulations must be established by the government to assure that people seeking stem cell treatments are not being taken advantage of by commercial interests,” Prof. Rasko’s message to Malaysia.

Prof. Rasko presented on two topics ‘Gene and Cell Therapy’ and ‘Haemopoiesis and the Stem Cell Niche’ at the seminar. 

 Prof. Dr. Tunku Kamarul from Universiti Malaya presented on ‘Stem Cell Research in Orthopaedics’, Dr Chin Sze Piaw from Cyopeutics Sdn Bhd lectured on ‘Current Clinical Applications of MSC in Malaysia’, and UTAR Centre for Stem Cell Research Chairperson Prof. Dr. Choo Kong Bung talked about ‘MicroRNAs in Stem Cells’.  Prof. Dr. Cheong Soon Keng, dean of UTAR Faculty of Medicine and Health Science, provided the opening remarks at the seminar.
 
The seminar attracted over 100 participants.  The sponsors of the seminar were All Eight Sdn Bhd, Axon Scientific Sdn Bhd, Biomarketing Sdn Bhd, Bita Lifescience Sdn Bhd, Matrioux Sdn Bhd and Stemedics Sdn. Bhd.

In the concluding remarks, Prof. Choo also announced that another one-day ‘UTAR Symposium on iPSC and Stem Cell Research: the Malaysian Scene 2013’ will be held on 29 November, 2013. The symposium will provide a platform for postgraduate students and young scientists in Malaysia to present their new research findings in stem cell research.

 

Prof. Rasko at the interview

 

VIPs at the seminar (from left): Prof. Cheong, Prof. Rasko, Prof. Choo, Prof. Kamarul and Dr. Chin

 

 

 

 

 

 

 

 

 

 

 

UTAR Centre

 for Stem Cell Research Chairperson

Prof. Dr. Choo Kong Bung

 

 

Members of the Centre for Stem Sell Research
 

No.

Member

Institution/ Faculty

Designation

E-mail

Research Area/ Interest

1

 

Emeritus Prof.
Dr. Cheong Soon Keng

UTAR FMHS

Dean;

Professorial Chair (Datuk and Datin Tan Kim Leong Professor of Medicine)

cheongsk@utar.edu.my

Blood cancer; dentritic cell vaccines; stem cells

2

Emeritus Prof.
Dr. Boo Nem Yun @ Mooi Nam Ying

UTAR FMHS

Deputy Dean (Academic Development and Undergraduate Programmes)

boony@utar.edu.my

G6PD deficiency-derived induced pluripotent stem cell (iPSC)

3

Prof. Dr. Choo Kong Bung

UTAR FMHS

Chairperson

Centre for Stem Cell Research

chookb@utar.edu.my

microRNA in cancer and stem cells

4

Prof. Dr Shelly Soo @ Soo Shelly

UTAR FMHS

Head of Department (Department of Medicine)

shellysoo@utar.edu.my

Cancer, stem cells

5

 

Assoc. Prof.
Dr Alan Ong Han Kiat

UTAR FMHS

Head of Programme (Postgraduate Programmes);

 

onghk@utar.edu.my

Cancer stem cells

6

 

Assoc. Prof.
Dr Gan Seng Chiew

UTAR FMHS

Associate Professor

gansc@utar.edu.my

iPSC derived from hair follicle keratinocytes

7

 

Assist. Prof.
Dr Leong Pooi Pooi

UTAR FMHS

Assistant Professor

Treasurer, CSCR

leongpp@utar.edu.my

Immunology; iPSC

8

Prof Dr Jenny Parameshvara Deva @ Nee Ng Gek Pheng

UTAR FMHS

Clinical Professor

Secretary, CSCR

jennypd@utar.edu.my

Genotype-phenotype in keratoconus/families; Stem cell research in treatment of ocular surface disorders

9

Prof. Dr M Parameshvara Deva a/l Muttu Ramalingam

UTAR FMHS

Professor

parameshvara@utar.edu.my

Mental illnesses

10 Assc. Prof. Dr Than Than Htwe UTAR FMHS

Associate Professor (Clinical)

thanth@utar.edu.my

Cancer research

No.

Associate member

Institution/ Faculty

Designation

E-mail

Research Area/ Interest

1

Dr Lim Kian Lam

UTAR FMHS;

Cryocord Sdn. Bhd.

Postdoctoral Fellow

promelkl@gmail.com

Stem cells

2

Wong Chee Yin

Cytopeutics Sdn. Bhd.

Chief Scientist

& PhD candidate

wongcyin@gmail.com

Mesenchymal stem cells in Regenerative medicine

3

Teoh Hoon Koon

PPUKM-MAKNA

Scientific Officer

& PhD candidate

hoonkoon@yahoo.com

Mesenchymal stem cells; RNAi;

iPSC; Disease Modelling

4

Erica Choong Pei Feng

PPUKM-MAKNA

Scientific Officer

erychoong@yahoo.com

Mesenchymal stem cells; Embryonic stem cells; iPSC

5

Liew Lee Chuen

PPUKM-MAKNA

Research Officer

& MSc. candidate

leechuen83@yahoo.com

Mesenchymal stem cells; Gene therapy

6

Ng Wei Yi

PPUKM-MAKNA

Research Officer

& MSc. candidate

ng_weiyi@hotmail.com

Immunobiology; Dendritic cell research

7

Nalini Devi A/P Verusingam

UTAR FMHS

MSc. candidate & Research assistant

nalinidv86@yahoo.com

Cancer stem cells; iPSC Regenerative medicine

8

Lim Sheng Jye

UTAR FMHS

MSc. candidate & Research assistant

shengjye2003@yahoo.com

Stem cells

9

Chiew Men Yee

UTAR FMHS

MSc. candidate & Research assistant

men-echiewf115@hotmail.com

Stem cells

10

   Soon Yuen Loon

UTAR FMHS

MSc. candidate & Research assistant

suen_yuenloon@hotmail.com

microRNA in cancer

11

Boo Lily

 

UTAR FMHS

Research assistant

ah_boo2001@yahoo.com

Cancer stem cells; iPSC

12

Norlaily Mohd Ali

 

UTAR FMHS

Research assistant

norlailyma@gmail.com

Mesenchymal stem cells

13

Teh Hui Xin

 

UTAR FMHS

Scientific Officer

tehhx@utar.edu.my

Stem cells

14

Ho Shu Cheow

UTAR FMHS

MSc. candidate & Research assistant

esther_sc87@hotmail.com

Stem cell; Hair regeneration

15

Nguyen Phan Nguyen Nhi

 

UTAR FMHS

Research assistant

nguyennhi204@hotmail.com

Stem cell ageing; microRNA

 

International Collaborators

 

Institution/Faculty

 

Designation

e-mail

Professor

Dr. Chiou Shih-Hwa

Department of Medical Research and Education, Taipei Veterans General Hospital &

Institute of Pharmacology, School of Medicine, National Yang-Ming University,  Taipei, Taiwan

 

Co-Director, Stem Cell Center, Taipei Veterans General Hospital

 

shchiou@vghtpe.gov.tw

Associate Professor

Dr. Huang Chiu-Jung

Department of Animal Science & Institute of Biotechnology,

College of Agriculture, Chinese Culture University, Taipei, Taiwan

 

Deputy Director, Office of Excellence in Teaching

hqr2@faculty.pccu.edu.tw

 

Stem cell terapi in Penang

 

 

 

Gleneagles Medical Centre Penang – overview

The Gleneagles Medical Centre is the pioneer private hospital in Penang. It is owned and managed by the Parkway Holdings Limited which operates other hospitals in neighboring countries. It is an acute care general hospital which specializes in a wide range of medical areas and equips advanced facilities.

 

It has been in service since 1973, and continues to provide quality care to both local and international patients until now.

 

 The Gleneagles Medical Centre Penang has undergone complete renovation from 1996 until 2000 which gave way for them to render the latest facilities for the best delivery of healthcare services. It is the first in the region to be awarded a three year full accreditation status by the Malaysian Society for Quality Health.

The Gleneagles Medical Centre has a total of 212 beds hospital-wide. There are over 40 professional doctors in the hospital designated in various specialty areas. The hospital offers foreign patient services which assists international patients and special packages for elderly people, pregnant women, and people seeking executive health screening programs.

Departments and specialty centers at Gleneagles Medical Centre Penang

        

        

        

       Bariatric Surgery

       Cardiac Surgery

       Cardiology

       Dialysis

       Endocrinology

       ENT

       Fertility Treatment

       Gastroenterology

       General Surgery

       Imaging

       Medical Check-ups

       Nephrology

       Neurology

       Neurosurgery

       Ob-Gyn

       Oncology

       Ophthalmology

       Orthopedics

       Pediatrics

       Rehabilitation

       Stem Cell Therapy

       Urology

Services

       Transportation services

       Family members can stay with patient

       Accommodation arrangements

Facilities

       Cafeteria/restaurant

       Recovery facilities

       Phone in rooms

       Internet connection

Certifications

       ISO 9001

Languages

       English

Numbers

       Number of doctors: 65

       Number of beds: 212

       Year established: 1973

 

 

 

 

Disclaimer:

The data provided in this page was collected from the Gleneagles Medical Centre Penang website (http://www.gleneagles-penang.com/), and other internet sources. last updated on Dec 26, 2013.
Please read our
disclaimer. If you have found any errors or missing data, please inform us.

Browse by specialty – Malaysia hospitals and clinics

       Aesthetics non surgical – Malaysia

 

 

Stem cell from fruit

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Just a spray may 10 miracle effectsSkin care has become a science in the modern, In addition to more women, many men also began to focus on the quality and safety of skin care products.

 

Our experts constantly to explore, finally got the breakthrough developed cell therapies Triple Stemcell Miracle Intense ESSENCE. In addition with PhytoCellTec Malus Domestica(Apple Stem Cell), PhytoCellTec Solar Vitis (Grape Stem Cell), PhytoCellTec Argan(Morocco Argan Fruit), DermCom Crocus Chrysanthus Bulb Extract(2012 Europh Innovation Prize),Hyaluronic Acid, Wheat Extract, Acid Hydrolyzed Cassava Extract, and has extensive with mineral springs.

Triple stemcell Miracle Intense Essence combining three kinds of plant stem cells, the invention won two European Innovation Invention Awards.

 

 

 

 

Twice Nobel Prize winner’s Dr. Linus Pualing recommended trace elements with small molecules and high penetrability , certainly be able to let you have immediate surface reaction, radiant, and confident.

 

 

Triple Stemcell Miracle Intense is very simple to use, after cleansing face, spray in the face. If there are some other parts, simply spray to see the miracle.

Uttwiller Spatlauber Apple Stemcell: Successfully developed by Mibelle Biochemistry chief scientist Dr Fred Zulli, this variety of apple stem cells can activate dormant stem cells in 80% of the human body cell regeneration and delay the aging process.

Gamay Teinturier Freaux Grape Stemcell: Successfully developed by Mibelle Biochemistry chief scientist Dr Fred Zulli, the product rich in anthocyanin pigments, delay the aging process effectively and prevent UV damage to skin tissue.

Argania Spinosa Morocco Argan Fruit: The world’s first proven have shown that the active substance having a dermal stem cells, the efficacy of protection and activation. Specifically for dermal stem cells ability to regenerate. In order to achieve a deep skin regeneration, skin restore firmness, and reduce wrinkles up to 26%.

DermCom Crocus Chrysanthus Bulb Extract: Won Innovation Award 2012 European invention, Its flower bulb extract based, by activating the communication between the cells of the skin, and thus reversed the degree of skin aging, the major applications are to promote the formation of collagen and elastin, improve skin density and help regain youth.

Sodium Hyaluronate: able to maintain skin elasticity, but also able to retain a relatively large amount of water , get smooth and moisturizing skin tissue, skin look plumpy, young and exlasting.

Wheat extract: By ECOCERT organic approval, Effectively inhibit the formation of melanin , but also to prevent UV-induced coloring, more rapid whitening.

Hydrolyzed cassava extract: Has immediate surface reaction, reduce wrinkles and fine lines, Firming the role of the skin

Mineral springs: Has a very rich trace elements, is a powerful anti-oxidant, fight again free radicals.

Copper: Neutralizes free radicals, contribute to the formation of collagen and elastin, and maintain the skin’s defense systems.
Selenium: against free radicals. Silicon: Contribute to the formation of collagen and elastin.
Zinc: can reduce the fine lines of the skin surface and uniform expression to the skin surface.
Magnesium: along with zinc to help skin tones.
Manganese: participate in the metabolism of collagen and eliminates free radical

Dr Linus Pualing YOU can trace every sickness, every disease and every aliment to a mineral deficiency

 

Nobel Prize winner’s Dr. Linus Pualing

Linus Pauling – Biographical

 

Linus Carl Pauling was born in Portland, Oregon, on 28th February, 1901, the son of a druggist, Herman Henry William Pauling, who, though born in Missouri, was of German descent, and his wife, Lucy Isabelle Darling, born in Oregon of English-Scottish ancestry.

Linus attended the public elementary and high schools in the town of Condon and the city of Portland, Oregon, and entered the Oregon State College in 1917, receiving the degree of B.Sc. in chemical engineering in 1922.

During the years 1919-1920 he served as a full-time teacher of quantitative analysis in the State College, after which he was appointed a Teaching Fellow in Chemistry in the California Institute of Technology and was a graduate student there from 1922 to 1925, working under Professor Roscoe G. Dickinson and Richard C. Tolman. In 1925 he was awarded the Ph.D. (summa cum laude) in chemistry, with minors in physics and mathematics.

 

Since 1919 his interest lay in the field of molecular structure and the nature of the chemical bond, inspired by papers by Irving Langmuir on the application of the Lewis theory of the sharing of pairs of electrons between atoms to many substances.

 In 1921 he suggested, and attempted to carry out, an experiment on the orientation of iron atoms by a magnetic field, through the electrolytic deposition of a layer of iron in a strong magnetic field and the determination of the orientation of the iron crystallises by polishing and etching the deposit, and microscopic examination of the etch figures.

With Professor Dickinson, he began in 1922 the experimental determination of the structures of some crystals, and also started theoretical work on the nature of the chemical bond.

Since his appointment to the Staff of California Institute of Technology, Professor Pauling was elected Research Associate in 1925; National Research Fellow in Chemistry, 1925-1926; Fellow of the John Simon Guggenheim Memorial Foundation, 1926-1927 (through this last he worked in European Universities with Sommerfeld, Schrödinger, and Bohr);

Assistant Professor of Chemistry, 1927-1929; Associate Professor, 1929-1931; Professor, 1931, when he was the first recipient of the American Chemical Society Award in Pure Chemistry – the Langmuir Prize – and Chairman of the Division of Chemistry and Chemical Engineering, and Director of the Gates and Crellin laboratories of Chemistry, 1936-1958.

 In 1963, he was awarded the Nobel Peace Prize.

Pauling is a member of numerous professional societies in the U.S.A. as well as in many European countries, India, Japan and Chile. Awards, medals, and honorary degrees were showered upon him in America and Europe, and in addition he was elected Rationalist of the Year for 1960 and Humanist of the Year for 1961.

 Several books have come from his pen, ranging from his most famous one The Nature of the Chemical Bond, and the Structure of Molecules and Crystals (1939, 1949, 1960) via General Chemistry (1947, 1953), which was translated into nine languages, to No More War! (1958, 1959,1962).

The subjects of the papers he published reflect his great scientific versatility: about 350 publications in the fields of experimental determination of the structure of crystals by the diffraction of X-rays and the interpretation of these structures in terms of the radii and other properties of atoms;

the application of quantum mechanics to physical and chemical problems, including dielectric constants, X-ray doublets, momentum distribution of electrons in atoms, rotational motion of molecules in crystals, Van der Waals forces, etc.;

 

 

the structure of metals and intermetallic compounds, the theory of ferromagnetism;

the nature of the chemical bond, including the resonance phenomenon in chemistry;

the experimental determination of the structure of gas molecules by the diffraction of electrons;

the structure of proteins;

the structure of antibodies and the nature of serological reactions;

 the structure and properties of hemoglobin and related substances;

abnormal hemoglobin molecules in relation to the hereditary hemolytic anemias;

 the molecular theory of general anesthesia;

an instrument for determining the partial pressure of oxygen in a gas; and other subjects.

Pauling married Ava Helen Miller of Beaver Creek, Oregon, in 1923. She is of English-Scottish and German descent. They have four children, Linus (Carl) Jr. (1925), Peter Jeffress (1931), Linda Helen (1932) and Edward Crellin (1937), and thirteen grandchildren.

From Nobel Lectures, Chemistry 1942-1962, Elsevier Publishing Company, Amsterdam, 1964

This autobiography/biography was written at the time of the award and first published in the book series Les Prix Nobel. It was later edited and republished in Nobel Lectures. To cite this document, always state the source as shown above.

 

Linus Pauling died on August 19, 1994

 

 

 

 

 

 

 

 

 

 

 

Stem cell terapi in Taipeh

Stem Cell Center

Taipei Veterams General Hospitals

 

Stem Cell Research Center – Taipei, Taiwan

Taipei Veterans General Hospital
No. 201, Sec. 2, Shih-Pai Road, Taipei 112
Taipei, Taiwan

Mission:

The Stem Cell Research Center of National Yang-Ming University focuses on studying stem cell biology, the characteristics and mechanisms of stem cells, and the applications of stem cells on human diseases. Applying stem cell therapy to repair injured cells and tissues, providing the adult stem cells in the body appropriate stimulation to regenerate vital organs, and exploring the role of stem cells in oncology and aging are the major interests of the center.

 

 

Director:

Oscar Kuang-Sheng Lee, MD, MSc, PhD

Background of Director:

The major research theme of Dr. Lee’s laboratory is plasticity and application of mesenchymal stem cells. Being an orthopaedic surgeon as well as a stem cell scientist, Dr. Lee is particularly interested in developing new application of mesenchymal stem cells to treat orthopaedic problems. The research interests also include osteoporosis, bone cell biology, and biophysical effects on bone cells and stem cells, and bone tumor biology. Dr. Lee is also the winner of Wu Ta-Yu Memorial Award from the National Science Council in Taiwan in 2006. In addition, he has been listed amongst the 2006-2007 International Who’s Who.

Major Accomplishments:

Dr. Lee’s lab has successfully isolated mesenchymal stem cells from human term umbilical cord blood. His work on this project was published in Blood on March 1, 2004 and his work was chosen as Cover Feature of that issue.

So far, this article has been cited more than 160 times. Also, his research team has demonstrated the differentiation potential of mesenchymal stem cells into hepatocytes in vitro and this has been published in Hepatology in December, 2004.

So far this article has been cited more than 110 times. The team also worked on an animal model of in utero transplantation of human mesenchymal stem cells into mice to investigate their in vivo differentiation potentials.

The team was able to demonstrate that human bone marrow-derived mesenchymal stem cells are able to differentiate into progenies originating from all three germ layers in vivo.

 

This work led to being awarded the New Investigator Recognition Award from the Orthopaedic Research Society in 2004.

 Importantly, the team also investigated the growth and differentiation of mesenchymal stem cells on Type 1 collagen nanofibers. This work has been published in Stem Cells in November 2006. Again his work was chosen as Cover Feature of that issue.

Current Projects:

The major research theme of Dr. Lee’s lab is plasticity and application of mesenchymal stem cells. Being an orthopaedic surgeon as well as a stem cell scientist, Dr Lee is particularly interested in developing new application of mesenchymal stem cells to treat orthopaedic problems.

The research interests also include osteoporosis, bone cell biology, and biophysical effects on bone cells and stem cells, and bone tumor biology.

The lab has successfully isolated mesenchymal stem cells from human term umbilical cord blood and this work has been published in Blood on March 1, 2004 and it has been chosen as Cover Feature of that issue.

So far, this article has been cited for more than 170 times. In addition, the research team has demonstrated the differentiation potential of mesenchymal stem cells into hepatocytes in vitro and this has been published in Hepatology in December, 2004 and the editorial highlight of the issue.

 So far this article has been cited for more than 110 times. The team also worked on an animal model of in utero transplantation of human mesenchymal stem cells into mice to investigate in their vivo differentiation potentials.

It has been demonstrated by us that that human bone marrow-derived mesenchymal stem cells are able to differentiate into progenies originated from all three germ layers in vivo.

This work leads to the winning of New Investigator Recognition Award from the Orthopaedic Research Society in 2004. Importantly, the team also investigated the growth and differentiation of mesenchymal stem cells on Type 1 collagen nanofibers. This work has been published in Stem Cells in November 2006 and again it was chosen as Cover Feature of that issue.

 


We have also looked into the possibility of incorporating gene therapy with stem cells to further enhance bone formation and found that concomitant overexpression of Cbfb and Cbfa-1 can efficiently enhance osteogenic differentiation of MSCs.

The results of which have been published in Stem Cells in 2007. Changes of mitochondrial biogenesis during osteogenic differentiation were also studied in human MSCs.

The results showed that coordinated regulation of mitochondrial biogenesis and antioxidant enzymes occurs synergistically during osteogenic differentiation of human MSCs and have been published in Stem Cells in June 2008.

To follow up on our previous study published in 2004, we investigated the therapeutic potential of MSCs for treatment of liver disease using a mouse model of fulminant hepatic failure and found that MSCs effectively rescued fulminant liver failure in a pre-clinical mouse model.

This work has been published in Gastroenterology in Jun 2008 and the editorial highlight of the issue.

Recently, Dr Lee and his graduate students reported the existence of stem cells in anterior and posterior cruciate ligaments of the human knee joint, as well as in human parathyroid glands. Both manuscripts have already been accepted by Cell Proliferation.


Dr. Lee is the winner of Wu Ta-Yu Memorial Award from the National Science Council in Taiwan in 2006. Besides, he has been listed amongst the 2006-2007 International Who’s who. He was also invited as the discussion leader of Gordon Conference in 2008
.

Website:

http://www.ym.edu.tw/scrc/

 

All information is © 2013 by the Cell Therapy Foundation

 

Driwan Stem Cell Therapy information center (continiu)

STEM CELL TERAPY

INFORMATION ONE

 

FOUNDER
 
Dr Iwan Suwandy,MHA
more infocontact
iwansuwandygmail.com
all free of charge
this info to all human in the world
with
 
THE MIGHTY GOD BLESS

TERAPI STEM CELL

Understanding Stem Cell


 
Stem cells are the body when an organ and tissue damage can make cells regenerate themselves , enough to cut the tail like a gecko can regenerate after it . Stem cell technology is the latest technology in the field of biotechnology , medical illness can not be cured at this time have a good effect , such as liver cirrhosis , renal failure , Parkinson’s , cerebral palsy , spinal cord injury , stroke , aging , diabetes and so on .

Patient Story

Here there are patients from Indonesia , the Philippines , Vietnam , Cambodia , and others . Once they do stem cell treatment , they get very good results .

 
Stem cell treatment gives confidence for people with Parkinson’s

 Stem cells,

Cirrhosis Patients Healing Light

 

treatment
humanist

We organize activities within a certain time , patients and families can participate .
Treatment Processes in Hospitals
This will enable you to consult and provide better service , we have a consultation center in Jakarta , Surabaya , and Medan .

Address in London:
Citicon Tower Floor 11, Block C2 , JL . Lieutenant General S. Parman Lot 72 , Slipi , West Jakarta 11410
Surabaya Address : 7th Floor Wisma BII no. 715 , JL . Youth no. 60-70 , Jakarta 60271
Address on field : Multatuli Indah Complex Block B – 50 , Medan , North Sumatra 20151

STEM CELL THERAPY IN CHINA


Reputation Modern Hospital Guangzhou ( Stem Cell Research & Treatment Center )


in Southeast AsiaModern Hospital Guangzhou ( Stem Cell Research & Treatment Center )

is an international organization of stem cell treatment , with some offices in Southeast Asia , with national politicians , universities , hospitals , community groups and the majority of patients to build rapport and trust .

treatment of Disease
• Liver Cirrhosis
• Kidney Failure
• Parkinson’s
• Cerebral Palsy
• Spinal Nerve Injury
• Stroke
• Anti – Aging
• Diabetes

The principle of treatment of diabetes with stem cell method


Stem cells are stem cells that are in our own bodies that have the ability to renew and restore .

Under these conditions , it can be classified as multifunctional cells , with the effect of restoring , supplement or remove damaged cells , even renewing organ .

Stem cell method for diabetes using stem cells ability to restore and renew damaged pancreatic cells . , So as to reduce the suffering of patients to insulin in a long period of time .


Stem cell method to treat a type of diabetes below
The effects of stem cell therapy for diabetes is very real , both to diabetes I, II diabetes , Gestational diabetes and the result is very effective .

Excess Stem cell treatment method


In the results of a study published < Journal of the American Medical Association > reported , the expert doctors perform stem cell therapy on 15 people with diabetes I in Brazil , the results are 13 people who successfully overcome their dependency on insulin , is also no longer dependent on drugs . The first patient who underwent this therapy has been stopped from insulin for 3 years now .


Minor side effects


Stem cell therapy is very safe , no adverse effects were small . Before stem cell therapy , generally they undergo treatment for anti – body , targeted induction treatment , and treatment to maintain stability and security for the sake of another series of tests , including toxicity testing , genetic testing , immunotoxicity testing , etc. .

The result proved , stem cell method has no side effects , safe and non-toxic .
Treatment using drugs is one way of treating diabetes , using drugs in a certain period can control diabetes for a while . In addition , the use of drugs in the long -term side effects are very large , because many people are affected by it , such as kidney failure , liver damage , etc. .
Short treatment process , only 3 weeks
The process of stem cell therapy is very short , it only takes 3 weeks . Stem cell therapy for diabetes , patients are required only in the hospital about 3 weeks , a process method takes approximately 1 month , in a short time , the interference experienced by people with diabetes will be resolved soon .
In traditional medicine , some patients are forced to live through insulin injections , even until the end of his life could not let go of their dependence on insulin .
The process of stem cell therapy
The course of the process of stem cell therapy , including prior to , execution , and after therapy , usually takes about 10 days , the following specifics :
( 1 ) Prior to therapy
Day 1 : Log Hospital . Register .
Day 2 : Examination . Overall checkup , with related indicators , ensuring the implementation of stem cell therapy .
Day 3-6 : The initial phase of therapy . Based on the patient’s condition and disease progression , performed stem cell therapy and control of body condition .
( 2 ) Stem cell therapy
Day 7 : Implementation of a stem cell transplant through the arteries . Through the parts that have been locally anesthetized , perform a stem cell transplant .
( 3 ) After therapy
Day 8-9 : Observation . Assessment of the effectiveness , as well as organize and assist patients in consolidation therapy .
Day 10 : Exit the hospital and the implementation of the re-examination . The doctor will inform the patient about the time to do a re-examination .
Related Reading :

Medical Team
 
Our expert team is regarded as “One of the founders of stem cell technology in China ” , there is a doctor in charge of a liver disease specialist , nephrology neurology da -rich clinical experience , there is also the MD and MA are mastering the current medical theory . We believe in the quality of medical care comes from the close cooperation of the entire team .
Medical Team
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Wang Ronghua
Imaging Center director of the stem cell transplant expert
The minimally invasive treatment of the Professional Committee of the Standing Committee member of the Chinese Society of Radiology , minimally invasive treatment of members of the Professional Committee of Chinese Anti – Cancer Association , Guangdong Province Anti – Cancer Association , Managing Editor of the editorial board of ” Modern Medical Imaging expert .
Have a deep knowledge on stem cell transplantation in the treatment of cirrhosis of the liver , and other related diseases , Wang Ronghua , where the team lead in implementation of team approach to the treatment of arterial stem cell transplantation , the use of stem cell transplantation in the treatment of an artery in the treatment of diabetes and cirrhosis of the liver this disease has a good effect , leading international

 


Memahami Stem Cell

Selinduk adalah ketika suatu organ tubuh kita mengalami kerusakan jaringan dan dapat membuat sel-sel regenerasi sendiri, cukup memotong ekor seperti tokek dapat beregenerasi setelah itu. Teknologi stem cell merupakan teknologi mutakhir di bidang bioteknologi, penyakit medis tidak dapat disembuhkan saat ini memiliki efek yang baik, seperti sirosis hati, gagal ginjal, Parkinson, cerebral palsy, cedera tulang belakang, stroke, penuaan, diabetes dan sebagainya.

 

 

 

 

 

 

Kisah Pasien

 

Disini ada pasien dari Indonesia, Filipina, Vietnam, Kamboja, dan lainnya. Setelah mereka melakukan pengobatan stem cell, mereka mendapatkan hasil yang sangat baik.

 

 

Pengobatan Stem sel memberi kepercayaan bagi penderita parkinson

 

 

 

Stem cells, Cahaya Kesembuhan Penderita Sirosis Sta

 

 

 

Menghadapi gagal ginjal, istri saya memberi saya ke

 

 

 

Stem cell Menyelamatkan Kebahagiaan Keluarga Pender

 

 

 

 

 

 

 

 

Kegiatan Dan Berita

Kami menyediakan pelayanan medis yang berkualitas kepada pasien di Asia Tenggara, juga memperoleh kepercayaan dari pemerintah daerah, rumah sakit, lembaga-lembaga akademis dan media.

 

 

[Indonesia]Kepala Angkatan Laut Indonesia bertemu dengan Ketua Kelompok Lin Cheng

 

 

 

[Indonesia]Delegasi dari Sulawesi Melakukan Kunjung

 

 

 

[Indonesia]Pemerintah Provinsi DKI Jakarta bertemu

 

 

Layanan Pasien Internasional

 

Pelayanan 
Rumah Sakit

 

layanan penerjemahan, diet bergizi, rawat inap, pembayaran dan asuransi kesehatan serta pengenalan akan layanan lainnya.

 

Informasi 
Mengenai Travel

 

visa, pemesanan tiket, antar jemput bandara, penukaran mata uang dan panduan layanan lainnya.

 

Perawatan 
Humanis

 

Kami dalam waktu tertentu menyelenggarakan kegiatan, pasien dan keluarga bisa berpartisipasi.

Proses Perawatan di Rumah sakit

Demi memudahkan Anda untuk berkonsultasi dan memberikan pelayanan yang lebih baik, kami memiliki pusat konsultasi di Jakarta, Surabaya, dan Medan. 

Alamat di Jakarta :

Menara Citicon Lantai 11 Blok C2, JL. Letjen S. Parman Kavling 72, Slipi, Jakarta Barat 11410 
Alamat di Surabaya : Wisma BII Lantai 7 no. 715, JL. Pemuda no. 60 – 70, Surabaya 60271
 
Alamat di Medan : Kompleks Multatuli Indah Blok BB – 50, Medan, Sumatera Utara 20151

STEM CELL THERAPY IN CHINA

Reputasi Modern Hospital Guangzhou (Stem Cell Research & Treatment Center)
di Asia Tenggara

Modern Hospital Guangzhou (Stem Cell Research & Treatment Center) adalah sebuah lembaga pengobatan sel induk internasional, dengan beberapa kantor di Asia Tenggara, dengan politisi nasional, universitas, rumah sakit, kelompok masyarakat dan mayoritas pasien untuk membangun hubungan baik dan saling percaya.

 

 

 

 

Pengobatan Penyakit

Prinsip pengobatan diabetes dengan metode stem cell

Stem cell adalah sel induk yang berada dalam tubuh kita sendiri yang memiliki kemampuan memperbaharui dan memulihkan. Dalam kondisi seperti ini, ia dapat dikelompokkan sebagai sel multifungsi, dengan efek memulihkan, melengkapi atau menghapus sel-sel yang rusak, bahkan memperbaharui organ. Metode stem cell terhadap penyakit diabetes menggunakan kemampuan stem cell yang dapat memulihkan dan memperbaharui sel pancreas yang rusak., sehingga dapat mengurangi penderitaan pasien terhadap insulin dalam jangka waktu yang lama.

Metode stem cell dapat mengobati jenis diabetes di bawah ini

Efek dari terapi stem cell terhadap penyakit diabetes sangat nyata, baik terhadap diabetes I, diabetes II, maupun Gestational diabetes hasilnya sangat efektif.

Kelebihan metode pengobatan Stem cell

Dalam hasil suatu penelitian yang diterbitkan < Journal of American Medical Association > dilaporkan, para dokter ahli melakukan terapi stem cell terhadap 15 orang penderita Diabetes I di Brazil, hasilnya terdapat 13 orang yang berhasil mengatasi ketergantungannya terhadap insulin, juga tidak lagi tergantung pada obat-obatan. Pasien pertama yang menjalani terapi ini sudah berhenti dari insulin selama 3 tahun hingga saat ini.

Efek sampingnya kecil

Terapi Stem cell sangat aman, efek sampingnya pun kecil. Sebelum melakukan terapi stem cell, umumnya mereka menjalani pengobatan untuk anti-body, pengobatan induksi bertarget, serta pengobatan untuk menjaga kestabilan dan serangkaian pemeriksaan demi keamanan lainnya, termasuk uji toksisitas, uji genetik, uji immunotoxicity, dll. Hasilnya membuktikan, metode stem cell tidak memiliki efek samping, aman dan tidak beracun.

Pengobatan dengan menggunakan obat-obatan adalah salah satu cara pengobatan diabetes, menggunakan obat-obatan dalam jangka waktu tertentu dapat mengontrol penyakit diabetes untuk sementara. Selain itu, penggunaan obat-obatan dalam jangka waktu yang lama mempunyai efek samping yang sangat besar, banyak orang yang dikarenakan hal itu terkena dampak, seperti gagal ginjal, rusaknya fungsi hati, dll.

Proses pengobatan yang singkat, hanya 3 minggu

Proses terapi stem cell sangat singkat, hanya membutuhkan waktu 3 minggu. Terapi stem cell terhadap diabetes, pasien hanya diharuskan ada di rumah sakit sekitar 3 minggu, satu proses metodenya membutuhkan waktu sekitar 1 bulan, dalam waktu yang singkat, gangguan yang dialami oleh penderita diabetes akan segera teratasi.

Pada pengobatan tradisional, beberapa pasien terpaksa hidup melalui suntikan insulin, bahkan sampai akhirnya hidupnya pun tidak bisa melepaskan ketergantungannya terhadap insulin.

Proses terapi sel induk

Proses jalannya terapi stem cell, termasuk sebelum, pelaksanaan, dan setelah terapi, biasanya memerlukan waktu sekitar 10 hari, berikut perinciannya :

(1) Sebelum terapi

Hari ke 1 : Masuk Rumah Sakit. Registrasi.

Hari ke 2 : Pemeriksaan. Menjalani pemeriksaan secara keseluruhan, dengan indikator terkait, memastikan pelaksanaan terapi stem cell.

Hari ke 3-6 : Tahap awal terapi. Berdasarkan kondisi dan perkembangan penyakit pasien, dilaksanakan terapi stem cell dan pengontrolan kondisi tubuh.

(2) Terapi Stem cell

Hari ke 7 : Pelaksanaan transplantasi stem cell melalui pembuluh arteri. Melalui bagian yang sudah dibius secara lokal, melakukan transplantasi stem cell.

(3) Setelah terapi

Hari ke 8-9 : Pengamatan. Penilaian terhadap efektifitas, serta mengatur dan membantu pasien dalam menjalani terapi konsolidasi.

Hari ke 10 : Keluar rumah sakit dan pelaksanaan pemeriksaan kembali. Dokter akan menginformasikan kepada pasien mengenai waktu untuk melakukan pemeriksaan kembali.

Bacaan terkait:

 

Tim Medis

Tim ahli kami dianggap sebagai “Salah satu pendiri teknologi Stem cell di China”, ada dokter penanggung jawab dari ahli penyakit hati, nefrologi da neurologi yang kaya akan pengalaman klinis, juga terdapat MD dan MA yang menguasai teori medis terkini. Kami percaya pada pelayanan medis yang berkualitas berasal dari kerjasama yang erat dari keseluruhan tim.

Tim Medis

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Wang Ronghua

Imaging Center direktur ahli transplantasi sel induk

The pengobatan minimal invasif dari Komite Profesional Komite Tetap anggota Masyarakat Cina Radiologi, pengobatan minimal invasif dari anggota Komite Profesional Anti-Kanker Chinese Association, Provinsi Guangdong Anti-Kanker Asosiasi, Managing Editor dari dewan redaksi dari “Modern Medical Imaging ahli.

Memiliki pengetahuan yang mendalam pada transplantasi stem cell dalam pengobatan sirosis hati, dan penyakit terkait lainnya, Wang Ronghua, di mana tim memimpin dalam pelaksanaan tim dari arteri pendekatan pengobatan transplantasi sel induk, penggunaan transplantasi stem cell dalam pengobatan saluran arteri dalam pengobatan diabetes dan sirosis hati penyakit ini telah efek yang baik, terkemuka internasional

 

Qin Zuxuan
Medical director of the clinical diabetes stem cell expert
Involved in the medical and clinical work for more than 20 years , in the case of incurable diseases , and clinical diagnosis and treatment of critically ill save her accumulated a lot of experience , while independently cardiac pacing , percutaneous tracheostomy surgery and emergency surgery in the medical oncology clinical work of master tumors and clinical skills , which specializes in the treatment of complications after cancer chemotherapy .
Stem cell research clinical treatment of diseases of the nervous system disease , complications of diabetes , cirrhosis , laboratory guidelines for stem cell expert differentiated treatment center , is primarily responsible for the formulation laboratory practices and laboratory personnel training and specific guidelines to protect the quality of the clinical application of stem cells to meet the relevant national standards of medical papers Cellular and hospital management articles published in several national magazines provincial magazine .
 
Zhen Xiang lin
Deputy Chief Physician cirrhosis clinical stem cell expert
Graduated from Wuhan Tongji Medical University , in clinical medicine , teaching , scientific research over the past 30 years , specializing in the use of methods of Integrative Medicine to treat various types of liver disease , cirrhosis and ascites and other diseases . He led the medical staff to continue to strive to diligently dedicated to study the biology of immune therapy and stem cell transplantation in the treatment of molecular biology and cell biology engineering scientific research involved in research and development and the first to introduce new technology biological immune cell therapy and stem in the treatment of liver disease usage requirements to make significant progress . More than 20 research papers in national magazines and province , including children with cytomegalovirus trigger jaundice clinical research ” , ” clinical observation and treatment of severe hepatitis cirrhosis high jaundice , and ascites Integrative Medicine medicine research and won several awards .
 
Zhenyan Li
Interventional Radiology , director of the stem cell transplant expert
The Chinese are well-known minimally invasive intervention specialist , a modern cancer center hospital treatment interventions targeted therapy expert , founder of the modern hospital intervention .
Involved in stem cell research and treatment of clinical interventions over the years , especially specializes in a wide range of diabetes , cirrhosis of the liver targeting selective percutaneous arterial transplant stem cell treatment , experienced . A significant effect .

 
Jiangxi Lin
Digestion stem cell medical treatment director of clinical experts
Chinese Medical Association members digestion process , the Chinese Medical Association Chinese and Western combined Gastroenterology Chapter member , has been working in Guangzhou 421 Medical Hospital of PLA , long-term commitment to the study of gastrointestinal diseases and gastrointestinal tumors early diagnosis and treatment , specializes in gastrointestinal tumors , endocrine diagnosis and treatment of blood , respiratory and other internal diseases . The first in the country to implement capsule endoscopy in the diagnosis and treatment of digestive diseases , has a wealth of successful experience , up to three of more than thirty published an article in a medical journal of Pharmacy , Medical misdiagnosed , percutaneous catheter treatment of primary liver cancer , ” published in the journal Naval Medical Technology Progress Award for the military Sidengjiang .
 
Jiao Yan
Director of Spinal Nerve Injury expert orthopedic stem cell therapy clinical
Medicine Department of Cell Biology research experts , bone defects and defective bone marrow experts involved in orthopedic clinical work 20 years to master a variety of advanced orthopedic treatment technology , specializing in the minimally invasive treatment of lumbar disc disease of the cervical limbs , joints , bones major orthopedic surgery . The successful implementation of minimally invasive treatment of lumbar disc surgery a thousand cases , a number of surgical technology has reached the leading domestic level , both at home and abroad will be the first neural stem cell transplantation technology applied to clinical research to treat spinal cord injuries and degenerative diseases , and achieved encouraging results are now well-known surgeon . Published several papers in academic journals in major orthopedic country .

Things to consider in the care of patients with kidney failure
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In everyday life , family or patients with kidney failure should learn how to care . Because through treatment , can prevent complications , mem slow the progression of the disease , and is also beneficial for healing . Here is the advice given by the Guangzhou Modern Hospital Center ( stem cell research ) about the care of patients with kidney failure :
Psychological treatment
Due to a period long enough kidney disease , mood patients often become depressed , pessimistic , panic , anxiety , and this is not good for healing .
The patient’s family should entertain the patients , so that patients can be optimistic face of illness , get rid of bad mood , and encourage patients to participate in daily activities .
Maintenance diet
Patients with renal failure diet must be considered nutritional balance , maintaining inventory source of nutrition , do not eat foods that are too oil .

Preferred diet of fresh , easy to digest , avoid flavoring foods and foods that are stimulating , controlling the intake of protein , salt and water , note the additional vitamins and minerals .
Daily care
In patients with renal failure symptoms will appear tired , dizziness , headache , nausea and diarrhea .
Therefore, it should ensure patients get enough rest and sleep , providing a comfortable environment , ensure the indoor temperature and cleanliness , attention to ventilate the room .
Patients who lie can not move must be helped to turn around periodically , to prevent pressure sores .
 If the disease had improved somewhat, should try to do activities that first light .
Received medical services 5
Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) is a professional hospital , you can feel very very satisfactory service here .
Inpatient rooms were clean and tidy , spacious and comfortable , available items of daily needs ; physician who made ​​a visit to the patient’s room accompanied by an interpreter , ask the patient , and calm the patient .
The attitude of the entire staff is friendly as well as international standards .

 The important thing is this hospital is one of the hospitals that have the authority early in stem cell research , has conducted numerous clinical studies of the methods of this stem cell therapy .
Sensing his own miracle of stem cell therapy
In February 2013 , I underwent stem cell therapy .
At that time I did not have the slightest doubt or fear .
Because previous doctors and nurses said to me : stem cell therapy , is a minimally invasive technique method , no surgery , safety is assured , does not cause bad side effects , etc. .
One week after treatment , most of the pain that I feel lost , I can walk normally up to 3 hours , I can also eat , change clothes , go to the bathroom , and other daily activities themselves .
In the recovery period , the doctor asked me to participate in various entertainment activities , which makes me even more rapid recovery , and strengthen the quality of my body .
This love is expressed in different ways depending
It has now been one year since I was discharged from the hospital . My current situation is stable , there are no signs of recurrence of osteonecrosis , I can go back to work . I tried to work while still maintaining my health , because everyone who has been paying attention to me , what I should make them worry again ? Osteonerosis drop can make a person’s health , it can also destroy the happiness of the family . But the disease still can not preclude affection between people . When sick, I really feel the love from all sides , the love of my wife , the love of my parents , the love of friends, and love of the entire hospital staff course . Good service and advanced technology is the embodiment of love from hospital .
Of Dao Ming Wei healthy
Indonesia, Jakarta , May 6, 2013

Notice : The results of treatment depends on the condition of each patient . Information on the website of Modern Hospital Guangzhou ( Stem Cell Research & Treatment Center ) is just for reference only , it can not serve as the basis for treatment of a medical diagnosis , can not replace the diagnosis and treatment of a doctor . For more details , please refer to the terms and conditions .
roots stem from China – Prof . Wang Ronghua
stem cell experts from China , Prof. . Wang Ronghua , who will explain about the use of stem cell method , the effects of treatment , and other knowledge .
Prof . Wang Ronghua has tremendous experience in the stem cell treatment for liver cirrhosis and other diseases .
Where Prof. Tim . Wang is right now is one team that did the first implementation in the stem cell treatment in China , clicking through the use of stem cell transplantation to treat cerebral arteries palsy , stroke , kidney failure , diabetes , liver cirrhosis and other diseases , which produce effects good , and internationally prominent .
Hold hands , and grow old
– Chinese Proverb
 
Picture : patients with renal failure Huang Ronghua , his condition improved after stem cell therapy , the urine from 0 ml to 1000 ml .
My name is Huang Ronghua , aged 63 , one of the Philippines’ kidney failure patients .
 About 10 days ago , I can not fully discharge the urine , two times a week for dialysis to sustain life .
10 days later , after the stem cell treatment , I was issued a 1000 ml urine in a day , a good spirit , strong legs .
After this day , I remember my 10 years of this disease , my biggest sentiment is : I am not the one who struggled . My wife always beside me , give me courage , let me continue to face it . He said : ” We have overcome together now . ” So , today there is not just because of me, but also my wife . ”

My wife and I met in the last 70s .
At that time I just went to the Philippines in Jinjiang , Fujian , engaged in import and export trade of milk .
The wife is a woman who is intelligent and gentle and loving , she helped me take care of business , housework .
After 20 years of hard work , we have become a businessman , day -to-day better day by day .
I think we should enjoy life with time – wife to accompany me for the rest of my life , and now I have to give him to live a good life .
But never think this time my body started no problem .
I was found to have had diabetes for 10 years .
Isolated from that day , the wife became ” personal care . ”
I’m in a long treatment . Wife gave me good care .
Seeing that I was in a stable condition , the child is slowly taking over my business .
 I want to remove the burden of his wife , finally can. However , fate once again make fun of us .

3 years ago , I often appeared fatigue , lack of energy , nausea , vomiting , bloating and back pain and other symptoms , and daily urine decreased .
Me to the nearest hospital , told that I was suffering from chronic renal failure .
 This to me , is a big blow . I do not believe this is true . Wife with strong , shook my hand and said : We are together beat the disease . I know that he is more sad than me .
Two years later , I can not fully discharge the urine , it should be twice a week hemo dialysis to sustain life .
During these two years , if not for the dedication of the wife , I’m afraid I will not survive – during my coma , he waited at the bedside , spoke some wonderful memories .
I was awake , he pushed me out to relax – I can only rely on a wheelchair for traveling . Wife gave me a body massage …… wife made ​​me realize the amount of love and selfless .
On 9 September 2013 , accompanied by my wife went to China for stem cell treatment .
I have no idea of stem cells , I just saw on the web about the stem cell treatment for kidney failure , we hold a glimmer of hope came to China , and pray that a miracle occurred .
3 days later , I had a stem cell therapy .
The first seven days , I was shivering again , appetite improves sleep quality improved , redness , strong legs , the indicator tends to normal , and urine output reached about 1000 ml per day .
For the first 10 days , I was able to leave the hospital –
I was also very surprised to see an unexpected effect , of course , most unhappy wife .
He saw my body is slowly getting better , has a smile on his face – in the last 10 years , maybe in 10 days this was the happiest moment for my wife ! ! !
 
Picture : patients with renal failure Huang Ronghua , thumbs-up for stem cell technology Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center )

On May 19 , his wife took me out of the hospital .
I suddenly remembered a Chinese proverb : hold hands , and grow old .
I think this should be explained as we do now – my wife and I were from different countries , with different languages ​​, customs and different ways of thinking .
But love will keep us together , but also because of love , so that we can better care for and care about each other .
I’m not sure how the future , I’m not sure what the future will face difficulties to , but I ‘m sure , no matter what , the wife is always by my side , giving me encouragement and courage to .
 
Picture : battle with kidney failure , his wife gave me encouragement and courage

Guangzhou Modern Hospital Chief Physician ( Stem Cell Research and Treatment Center ) Xianglin advised :
Huang Ronghua patient first came to our hospital when malaise , lack of energy , nausea and abdominal distention , pain , inability to urinate , and double- face and lower extremities edema , serum creatinine check up 1022.00um0l / L.
After stem cell therapy , urine Huang Ronghua increased to 1000 ml , and strong limbs , a good spirit , appetite and an increase in the quality of sleep , facial redness .
 After examination , the body indicators are within normal range .
During treatment , the greatest feeling Huang has been given to patients with the encouragement and confidence , taking care of the daily diet . Today, the health of the patient is discharged from the hospital , and I hope they have good health and family harmony .

Notice : The results of treatment depends on the condition of each patient . Information on the website of Modern Hospital Guangzhou ( Stem Cell Research & Treatment Center ) is just for reference only , it can not serve as the basis for treatment of a medical diagnosis , can not replace the diagnosis and treatment of a doctor . For more details , please refer to the terms and conditions .

Hospital Room Position And Environment
Adjacent to the Hospital of Baiyun Mountain and have fresh air .
We have VIP rooms and standard rooms , with private bathroom, living room , full kitchen and other facilities . [ Hospital Environment ]
    

HOSPITAL ENVIRONMENT
• The location and profile
• Conditions inpatient unit
• Facility environment
• Doctors and Nurses
The hospital is supported by natural air – Baiyun Mountain , the beautiful scenery .
 
Hospitals are in the vicinity of Mount BaiYun .
 
Escalators Hospital .
 
space Nurse
 
spacious hall
 
Hospitals with circular staircase
 
laboratory
activity
News
 
Translation Services
We provide Indonesian translators , UK , Philippines , Thailand , Cambodia , Vietnam and other languages ​​.
  
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Diet and Climate
We have a professional nutritionist will determine your nutritional intake and also provide a kitchen for the patient or family to make favorite foods . Guangzhou is located in the temperate zone , the annual average temperature is 22.8 .
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Telephone and Internet Networks
We can provide phone cards that can be used in the territory of China or if the patient using their own phone card country please activate international roaming . Wifi is provided in the patient’s room , and the patient can also watch state television channel itself .
   
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Health Insurance
Patients who purchase health insurance in their own country , to consult with the insurance company or the center of our consultation regarding insurance , the hospital will issue a proof of payment for the treatment of patients in the hospital .

Day-to- day care
Our medical staff on duty 24 hours . Room cleaning and laundry services provide , as well as the delivery of breakfast and tea -break .
   

Companion Services For Patients
Patient rooms provide 1 bed for family members accompanying the patient, family members can also enjoy the food provided by the hospital cafeteria .

religion
We respect the religious beliefs of each patient , so we provide a place for prayer , and can also help patients contact the church around .
 

method of Payment
You can pay by cash ( limited RMB and U.S. dollar ) , you can also use VISA , MasterCard , JCB credit cards and other credit cards .
 Patients can pay medical expenses in the office , or you may directly transfer money to bank accounts hospital .

Repeat visits
After patients are discharged from the hospital , the staff will go through the center of our consultation visits , e – mail or telephone to ask medical condition of the patient , the patient’s recovery , and provide other related services . Before the next visit , consultation center staff will remind you to re- consult with the appropriate time

 

Qin Zuxuan

Direktur medis diabetes ahli sel induk klinis

Terlibat dalam pekerjaan medis dan klinis selama lebih dari 20 tahun, dalam hal penyakit tak tersembuhkan, dan diagnosis klinis dan pengobatan sakit kritis menyelamat -kannya terakumulasi banyak pengalaman, pacing jantung secara independen sementara, percutaneous bedah trakeostomi darurat dan operasi dalam pekerjaan onkologi medis klinis menguasai tumor dan keterampilan klinik, yang mengkhususkan diri dalam pengobatan komplikasi setelah kemoterapi kanker.

Penelitian sel induk pengobatan klinis dari penyakit penyakit sistem saraf , komplikasi diabetes , sirosis , laboratorium pedoman bagi ahli sel induk pusat perawatan dibedakan , terutama bertanggung jawab untuk formulasi praktik laboratorium dan laboratorium pelatihan personil dan pedoman khusus untuk melindungi aplikasi klinis kualitas dari sel-sel induk untuk memenuhi standar nasional yang relevan makalah medis Seluler dan artikel manajemen rumah sakit diterbitkan dalam majalah nasional beberapa majalah provinsi.

Zhen Xiang lin

Dokter Wakil Kepala sirosis ahli sel induk klinis

Lulus dari Wuhan Tongji Medical University, dalam kedokteran klinis, pengajaran, penelitian ilmiah selama 30 tahun terakhir, mengkhususkan diri dalam penggunaan metode Integrative Medicine untuk mengobati berbagai jenis penyakit hati, sirosis dan ascites dan penyakit lainnya. Dia memimpin staf medis untuk terus berusaha untuk tekun didedikasikan untuk mempelajari terapi kekebalan biologi dan transplantasi stem cell dalam pengobatan biologi molekuler dan sel penelitian rekayasa biologi ilmiah yang terlibat dalam penelitian dan pengembangan dan yang pertama memperkenalkan teknologi baru terapi sel biologi kekebalan tubuh dan batang dalam pengobatan penyakit hati persyaratan penggunaan membuat kemajuan yang signifikan. Makalah penelitian lebih dari 20 dalam majalah nasional dan provinsi, termasuk anak-anak dengan sitomegalovirus memicu penyakit kuning penelitian klinis “,” pengamatan klinis dan pengobatan hepatitis berat sirosis penyakit kuning yang tinggi, dan ascites Integrative Medicine pengobatan penelitian dan memenangkan beberapa penghargaan.

Zhenyan Li

Interventional Radiologi, direktur ahli transplantasi sel induk

Orang Cina yang terkenal intervensi spesialis minimal invasif, rumah sakit pusat kanker modern pengobatan intervensi ahli terapi yang menarget, rumah sakit pendiri modern yang intervensi.

Terlibat dalam penelitian stem cell dan pengobatan intervensi klinis selama bertahun-tahun, terutama mengkhususkan diri dalam berbagai diabetes, sirosis hati menargetkan arteri transplantasi perkutan selektif pengobatan sel induk, berpengalaman. Sebuah efek yang signifikan.

 

 

 

 

Jiangxi Lin

Pencernaan Direktur pengobatan medis sel induk ahli klinis

Chinese Medical anggota proses pencernaan Asosiasi, Asosiasi Medis China Cina dan Barat anggota Bab Gastroenterologi gabungan, telah bekerja di Guangzhou 421 Rumah Sakit Medis dari PLA, komitmen jangka panjang untuk mempelajari penyakit gastrointestinal dan tumor pencernaan diagnosis dini dan pengobatan, spesialisasi dalam tumor gastrointestinal, endokrin diagnosis dan pengobatan darah, pernapasan dan penyakit internal lainnya. Yang pertama di negara itu untuk melaksanakan endoskopi kapsul dalam diagnosis dan pengobatan penyakit pencernaan, memiliki kekayaan pengalaman sukses, sampai tiga lebih dari tiga puluh menerbitkan sebuah artikel dalam jurnal medis dari Farmasi, Kedokteran misdiagnosed, percutaneous perawatan kateter kanker hati primer, “diterbitkan dalam jurnal Medical Naval untuk Progress Teknologi Penghargaan militer Sidengjiang tersebut.

Jiao Yan

Direktur Cedera Syaraf Tulang belakang ortopedi batang ahli terapi sel klinis

Kedokteran Departemen penelitian para ahli Biologi Sel, cacat tulang dan ahli tulang cacat sumsum terlibat dalam pekerjaan klinis ortopedi 20 tahun untuk menguasai berbagai teknologi pengolahan ortopedi canggih, mengkhususkan diri dalam pengobatan minimal invasif dari penyakit disc lumbal serviks dari tungkai, sendi, tulang ortopedi operasi besar. Keberhasilan pelaksanaan pengobatan minimal invasif operasi disc lumbal dari seribu kasus, sejumlah teknologi bedah telah mencapai tingkat domestik terkemuka, baik di dalam maupun luar negeri akan menjadi sel induk pertama saraf transplantasi teknologi yang diterapkan untuk penelitian klinis untuk mengobati Cedera Syaraf Tulang belakang dan penyakit degeneratif, dan mencapai mendorong hasilnya saat ini ahli bedah terkenal. Ditampilkan beberapa makalah di dalam negeri jurnal akademis utama ortopedi.

 

 

Hal yang perlu diperhatikan dalam perawatan terhadap penderita gagal ginjal

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Dalam kehidupan sehari-hari , Keluarga atau pasien gagal ginjal harus mempelajari cara perawatan. Karena melalui perawatan , dapat mencegah terjadinya komplikasi, mem perlambat perkembangan penyakit,dan juga bermanfaat bagi kesembuhan. Berikut ini adalah saran yang diberikan oleh Modern Hospital Guangzhou (Pusat penelitian stem sel) tentang perawatan terhadap penderita gagal ginjal :

Perawatan Psikologis

Berhubung periode penyakit gagal ginjal cukup lama, suasana hati pasien sering menjadi depresi, pesimis, panik, cemas, dan ini sangat tidak baik bagi penyembuhan.

Keluarga pasien hendaknya menghibur pasien, agar pasien dapat dengan optimis menghadapi penyakitnya, hilangkan suasana hati yang tidak baik, dan mendorong pasien untuk turut berpartisipasi dalam kegiatan sehari-hari.

Perawatan pola makanan

Pola makan penderita gagal ginjal harus diperhatikan keseimbangan gizinya, menjaga sumber persediaan gizi,jangan makan makanan yang terlalu minyak.

 

 

Pola makanan diutamakan tawar, mudah dicerna,hindari penyedap makanan dan makanan yang bersifat merangsang, mengontrol asupan protein, garam dan air, perhatikan tambahan vitamin dan mineral.

Perawatan sehari-hari

Pada penderita gagal ginjal akan muncul gejala lelah, pusing, sakit kepala, mual dan diare.

Oleh karena itu harus menjamin pasien mendapatkan istirahat dan tidur yang cukup, menyediakan lingkungan yang nyaman, menjamin suhu dan kebersihan dalam ruangan, memperhatikan ventilasi ruangan.

Pasien yang baring tidak bisa bergerak harus dibantu untuk membalikkan badannya secara berkala,untuk mencegah dekubitus.

 Jika penyakit agak membaik, boleh coba untuk melakukan aktivitas yang ringan dulu.

Mendapat pelayanan medis bintang 5

Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) adalah sebuah rumah sakit profesional, anda dapat merasakan pelayanan yang sangat amat memuaskan di sini.

Kamar inap yang bersih dan rapi, luas dan nyaman, tersedia barang-barang kebutuhan sehari-hari; dokter ahli yang melakukan kunjungan ke kamar pasien dengan didampingi penerjemah, menanyakan keadaan pasien, serta menenangkan pasien.

Sikap dari seluruh stafnya merupakan standar internasional serta ramah.

 

 

 Yang terpenting adalah rumah sakit ini merupakan salah satu rumah sakit yang mempunyai wewenang sejak dini dalam penelitian stem cell, telah melakukan berbagai penelitian secara klinis terhadap metode terapi stem cell ini.

Merasakan sendiri keajaiban dari terapi stem cell

Pada Februari 2013, saya menjalani terapi stem cell.

Saat itu saya tidak mengalami keraguan atau ketakutan sedikit pun.

Karena sebelumnya dokter dan perawat berkata pada saya : terapi stem cell, merupakan metode teknik minimal invasif, tidak ada tindakan operasi, keamanannya terjamin, tidak menimbulkan efek samping yang buruk, dll.

Satu minggu setelah menjalani terapi, sebagian besar rasa sakit yang saya rasakan hilang, saya dapat berjalan secara normal hingga 3 jam, saya juga dapat makan, mengganti baju, ke kamar mandi, dan kegiatan sehari-hari lainnya sendiri.

Dalam masa pemulihan, para dokter mengajak saya untuk mengikuti berbagai kegiatan hiburan, yang membuat pemulihan saya semakin cepat, dan memperkuat kualitas tubuh saya.

Rasa cinta diungkapkan dengan cara yang berbeda-beda

Kini telah satu tahun semenjak saya keluar dari rumah sakit. Keadaannya saya saat ini stabil, tidak ada tanda-tanda kekambuhan dari osteonekrosis, saya dapat kembali bekerja. Saya berusaha bekerja sambil tetap menjaga kesehatan saya, karena semua orang yang telah memperhatikan saya, apa saya boleh membuat mereka khawatir kembali? Osteonerosis dapat membuat kesehatan seseorang drop, juga dapat menghancurkan kebahagiaan keluarga. Tapi penyakit tetap tidak bisa menghalangi kasih sayang antar manusia. Ketika jatuh sakit, saya benar-benar merasakan cinta dari semua pihak, cinta dari istri saya, cinta dari orang tua saya, cinta dari teman-teman, dan cinta dari seluruh staf rumah sakit tentunya. Pelayanan yang baik dan teknologi canggih merupakan perwujudan cinta dari rumah sakit.

Dari Dao Ming Wei yang sehat

Indonesia, Jakarta, 6 Mei 2013

 

Pemberitahuan : Hasil pengobatan tergantung pada kondisi setiap pasien. Informasi di website Modern Hospital Guangzhou (Stem Cell Research & Treatment Center) hanyalah sebagai referensi saja, tidak dapat dijadikan sebagai dasar diagnosa medis untuk pengobatan, tidak bisa menggantikan diagnosa dan pengobatan dokter. Untuk lebih jelas, silahkan lihat syarat dan ketentuan.

akar stem cell dari China – Prof. Wang RongHua

ahli stem cell dari China, Prof. Wang RongHua, yang akan menjelaskan tentang penggunaan metode stem cell, efek pengobatan, dan pengetahuan lainnya.

Prof. Wang RongHua memiliki pengalaman luar biasa dalam pengobatan stem cell untuk sirosis hati dan penyakit lainnya.

Tim dimana Prof. Wang berada saat ini merupakan salah satu tim yang melakukan implementasi pertama pada sel induk dalam pengobatan di China, meng gunakan transplantasi sel induk melalui pembuluh arteri untuk mengobati celebral palsy, stroke, gagal ginjal, diabetes, sirosis hati dan penyakit lainnya, yang menghasilkan efek yang baik, dan terkemuka secara internasional.

Berpegangan tangan, dan menjadi tua

– Peribahasa Cina

 

Gambar: pasien dengan gagal ginjal Huang Ronghua, kondisinya membaik setelah terapi sel induk, urin dari 0 ml sampai 1000 ml.

Nama saya Huang Ronghua, berusia 63, satu dari pasien Filipina yang gagal ginjal.

 Sekitar 10 hari yang lalu, saya tidak bisa sepenuhnya mengeluarkan urin, dua kali seminggu untuk cuci darah untuk mempertahankan hidup.

10 hari kemudian, setelah pengobatan sel induk, saya mengeluarkan urine 1000 ml dalam sehari, semangat yang baik, kaki yang kuat.

Setelah hari ini, saya ingat penyakit 10 tahun saya ini, sentimen terbesar saya adalah: Saya bukan orang yang berjuang. Istri saya selalu di samping saya, beri saya keberanian, biarkan saya tetap menghadapi hal ini. Dia mengatakan: “Kami telah mengatasi bersama-sama sekarang.” Jadi, hari ini ada bukan hanya karena saya, tapi juga istri saya.”

 

Saya dan istri saya bertemu di tahun 70-an lalu.

Saat itu saya hanya pergi ke Filipina di Jinjiang, Fujian, terlibat dalam impor dan ekspor perdagangan susu.

Istri adalah seorang yang cerdas dan wanita yang lembut dan penuh kasih, dia membantu saya mengurus bisnis, pekerjaan rumah tangga.

Setelah 20 tahun kerja keras, kita telah menjadi pebisnis, hari-hari yang lebih baik hari demi hari.

Saya pikir kita harus menikmati hidup dengan waktu – istri untuk menemani saya untuk sisa hidupku, dan sekarang saya harus memberikan dia untuk menjalani kehidupan yang baik.

Tapi tidak pernah berpikir saat ini tubuh saya mulai ada masalah.

Saya ditemukan telah menderita diabetes selama 10 tahun.

Terisolasi dari hari itu, istri menjadi “perawatan pribadi.”

Saya dalam pengobatan panjang. Istri memberi saya perawatan yang baik.

Melihat bahwa saya dalam kondisi stabil, anak perlahan-lahan mengambil alih bisnis saya.

 Saya ingin menghapus beban istri, akhirnya bisa. Namun, nasib sekali lagi mengejek kita.

 

3 tahun yang lalu, saya sering muncul kelelahan, kekurangan energi, mual, muntah, kembung dan nyeri punggung dan gejala lain, dan urin harian menurun.

Saya ke rumah sakit terdekat, diberitahukan bahwa saya menderita gagal ginjal kronis.

 Ini bagi saya, adalah pukulan besar. Aku tidak percaya ini benar. Istri dengan tegar, menjabat tangan saya dan berkata: Kita bersama mengalahkan penyakit itu. Saya tahu bahwa dia lebih sedih daripada saya.

Dua tahun kemudian, saya tidak bisa sepenuhnya mengeluarkan urin, perlu dua kali seminggu hemo dialisis untuk mempertahankan hidup.

Selama dua tahun ini, jika bukan karena dedikasi istri, aku takut aku tidak akan bertahan – selama saya koma, dia menunggu di samping tempat tidur, berbicara beberapa kenangan indah.

Aku terjaga, dia mendorong saya keluar untuk bersantai – saya hanya bisa mengandalkan kursi roda untuk bepergian. Istri memberi saya pijat tubuh …… istri membuat saya menyadari besarnya kasih dan tanpa pamrih.

Pada 9 September 2013, didampingi oleh istri saya pergi ke China untuk pengobatan sel induk.

Saya tidak tahu dari sel induk, saya hanya melihat di web tentang pengobatan sel induk untuk gagal ginjal, kami memegang secercah harapan datang ke Cina, dan berdoa agar mukjizat terjadi.

3 hari kemudian, aku punya terapi sel induk.

Tujuh hari pertama, saya menggigil lagi, nafsu makan meningkatkan kualitas tidur membaik, kemerahan, kaki kuat, indikator cenderung normal, dan output urin mencapai sekitar 1000 ml per hari.

Untuk 10 hari pertama, saya bisa meninggalkan rumah sakit –

Saya juga sangat terkejut melihat efek tak terduga, tentu saja, istri yang paling bahagia.

Dia melihat tubuh saya perlahan-lahan menjadi lebih baik, memiliki senyum di wajahnya – dalam 10 tahun terakhir, mungkin pada 10 hari ini lah saat paling bahagia untuk istri saya! ! !

 

  Gambar: pasien dengan gagal ginjal Huang Ronghua, mengacungkan jempol untuk teknologi sel induk Modern Hospital Guangzhou (Stem Cell Research and Treatment Center)

 

 

Pada tanggal 19, istrinya mengantar saya keluar rumah sakit.

Aku tiba-tiba teringat pepatah Cina: berpegangan tangan, dan menjadi tua.

Saya pikir ini harus dijelaskan seperti sekarang kita melakukannya – saya dan istri saya dari negara yang berbeda, dengan bahasa yang berbeda, kebiasaan dan cara berpikir berbeda.

Tapi cinta akan membuat kita bersama-sama, tetapi juga karena cinta, sehingga kami dapat lebih merawat dan peduli satu sama lain.

Saya tidak yakin bagaimana masa depan, saya tidak yakin apa yang masa depan akan menghadapi ke sulitan , tapi saya yakin, tidak peduli apa, istri selalu berada di sisi saya, memberi saya dorongan dan ke beranian.

 

  Gambar: pertarungan dengan gagal ginjal, istri memberi saya dorongan dan keberanian

 

Dokter Kepala Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) Xianglin berpesan: 

pasien Huang Ronghua pertama kali datang ke rumah sakit kami ketika malaise, kekurangan energi, mual dan distensi abdomen, nyeri, ketidakmampuan untuk buang air kecil, dan wajah dan ganda edema ekstrimitas bawah, serum kreatinin check up 1022.00um0l / L.

Setelah terapi sel induk, urin Huang Ronghua meningkat menjadi 1000 ml, dan anggota tubuh yang kuat, semangat yang baik, nafsu makan dan pe ningkatan kualitas tidur, wajah kemerahan.

 Setelah dilakukan pemeriksaan, tubuh indikator berada dalam kisaran normal.

Selama pengobatan, perasaan terbesar Huang telah diberikan kepada pasien dengan dorongan dan kepercayaan diri, mengurus pola makan sehari-hari. Hari ini, kesehatan pasien dipulangkan dari rumah sakit, dan saya berharap mereka memiliki kesehatan yang baik dan keharmonisan keluarga.

 

 

 

 

 

 

Pemberitahuan : Hasil pengobatan tergantung pada kondisi setiap pasien. Informasi di website Modern Hospital Guangzhou (Stem Cell Research & Treatment Center) hanyalah sebagai referensi saja, tidak dapat dijadikan sebagai dasar diagnosa medis untuk pengobatan, tidak bisa menggantikan diagnosa dan pengobatan dokter. Untuk lebih jelas, silahkan lihat syarat dan ketentuan.

 

Posisi Kamar Rumah Sakit Dan Lingkungan

Rumah Sakit berdekatan dengan Gunung Baiyun dan memiliki udara yang segar.

Kami memiliki kamar VIP dan kamar standar, dengan kamar mandi dalam, ruang tamu, dapur dan fasilitas lengkap lainnya. [Lingkungan Rumah Sakit]

 

 

LINGKUNGAN RUMAH SAKIT

Rumah sakit yang didukung oleh udara alami — Gunung BaiYun, pemandangan indah.

 

Rumah Sakit berada di sekitar Gunung BaiYun.

 

Eskalator Rumah Sakit.

 

Ruang Perawat

 

aula yang luas

 

Rumah sakit dengan tangga melingkar

 

Laboratorium

Kegiatan
Dan Berita

 

Layanan Terjemahan

Kami menyediakan penerjemah bahasa Indonesia, Inggris, Filipina, Thailand, Kamboja, Vietnam dan bahasa lainnya.

 

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Diet Dan Iklim

Kami memiliki ahli gizi profesional yang akan menentukan asupan gizi anda dan juga menyediakan dapur bagi pasien atau keluarga untuk membuat makanan kesukaan. Guangzhou terletak di zona subtropis, suhu rata-rata tahunan adalah 22.8 .

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Telepon Dan Jaringan Internet

Kami dapat menyediakan kartu telepon yang bisa digunakan di wilayah Cina atau jika pasien mengunakan kartu telepon negara mereka sendiri silahkan mengaktifkan roaming internasional. Dalam kamar pasien disediakan wifi, dan pasien juga dapat menonton saluran televisi negara sendiri.

 

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Asuransi Kesehatan

Pasien yang membeli asuransi kesehatan di negara mereka sendiri, dapat berkonsultasi dengan perusahaan asuransi atau pusat konsultasi kami mengenai asuransi, rumah sakit akan mengeluarkan bukti pembayaran pengobatan pasien selama dirumah sakit.

 

 

 

Perawatan Sehari-hari

Staf medis kami bertugas 24 jam. Kamar menyediakan layanan kebersihan dan laundry, serta pengiriman sarapan dan tea-break.

 

 

 

Layanan Bagi Pendamping Pasien

Kamar pasien menyediakan 1 tempat tidur bagi anggota keluarga yang mendampingi pasien, keluarga pasien juga dapat menikmati makanan yang disediakan oleh kantin rumah sakit.

 

Agama

Kami menghormati kepercayaan religius setiap pasien, karena itu kami menyediakan tempat untuk berdoa, dan juga dapat membantu pasien menghubungi gereja disekitar.

 

 

 

 

Metode Pembayaran

Anda dapat melakukan pembayaran dengan tunai (terbatas RMB dan dolar AS), Anda juga dapat menggunakan VISA, MasterCard, kartu kredit JCB dan kartu kredit lainnya.

 Pasien dapat membayar biaya pengobatan di kantor, atau Anda boleh langsung mentransfer uang ke rekening bank rumah sakit.

 

Kunjungan Ulang

Setelah pasien keluar dari rumah sakit, staf pusat konsultasi kami akan melalui kunjungan, e-mail atau telepon untuk menanyakan kondisi pengobatan pasien, pemulihan pasien, dan menyediakan layanan yang berhubungan lainnya. Sebelum kunjungan berikutnya, staf pusat konsultasi akan mengingatkan anda untuk kembali berkonsultasi dengan tepat waktu.

 

 

 

 

Recognized by the central government and university

[ Indonesia ] Jakarta Provincial Government Jakart
March 23, 2013 , the provincial government in Jakarta , the Indonesian Foreign Minister Meets Chinese Brotherhood Group Chairman Lin Zhi Cheng . Both sides fraternity Medical Group Investment in Indonesia to discuss cooperation matters … [ Read more ]

Jakarta Provincial Government met with the Foreign Minister of Gano ” old friend ” of China
March 23, 2013 , the provincial government in Jakarta , Indonesia , Minister of Foreign Affairs in Berlin , Sura Hotel Gargano filled with ” old friend ” of China China Brotherhood Group Chairman Lin Cheng . Gano Minister Lin Cheng welcomed the arrival of the medical fraternity party and investment in Indonesia to discuss cooperation matters .

Chairman Lin Zhi Cheng to Gano ‘s first minister for many years chairman of Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center )
the support and assistance provided by the Office , expressing gratitude Indonesia .
 Lin Cheng Chairman said : China and India established diplomatic ties 60 years , bilateral friendly cooperative relations have been developed in cooperation deepening medical .
In early 2006 , China Hospital of Guangzhou fraternity Group Modern ( Stem Cell Research and Treatment Center ) on the establishment of an office in Jakarta , began contacting local hospitals for exchange and cooperation .
 This initiative was when he was president of the Navy General Hospital General Coulee Indonesian Novo appreciated .
Over the years , the mission of the office is to
 ” providing the most convenient for human health , the most intimate , high- quality medical services , ” the company’s mission , received a lot of diabetes , cirrhosis , diseases such as cerebral palsy and Parkinson’s patient consultation , and provide free treatment programs .

Office also organized a health talk repeatedly publicize knowledge of various diseases of defense , so that more people learn to prevent disease in Indonesia , to get rid of the disease .

” Health Without Borders , Love Without Boundaries , every advanced medical services should be distributed to the entire world community , we must be in Southeast Asia and around the world to promote the common development of a medical career and make every effort . ” Lin Zhi Cheng said with conviction and passion .
Minister Gano against friendly relations expressed high appreciation and said ,
” either now or in the future , China’s Fraternity Group is our old friend . ”
Gano Minister sincerely hope fraternal groups to strengthen cooperation with the Indonesian national hospital , the real benefit of two people !

President Adi Husada hospital Indonesia , Guo Shao Lin and his wife received an invitation to the Guangzhou Modern Hospi
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Since the Guangzhou Modern Hospital ( Center for Research and Treatment of Stem Cells ) founded , never stopped working with the organization in question is well-known in the world , through comparative studies and research techniques , to maintain right medicine concepts , services and advanced techniques .

July 6 , President Adi Husada hospital Indonesia , Guo Shao Lin and his wife received an invitation to the Guangzhou Modern Hospital ( Center for Research and Treatment of Stem Cells ) .
During the visit , Guo Shao Lin showed his admiration for the environment and servicing the Guangzhou Modern Hospital ( Center for Research and Treatment of Stem Cells ) .
Recently , Guo Shao Lin and wife with the research center staff assisted stroll to the famous tourist spot of Guangzhou , ” Bai Yun Shan ” .

Erland University of Surabaya , Indonesia conduct academic exchanges with the center of our doctors .
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More recently , a delegation of about 40 doctors from the University of Surabaya Indonesia grants , in traditional medicine department under the leadership of a responsible person to Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) for academic exchange .
According to the medical department officials said the line was chosen Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) as an academic purposes , is based Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) on the power and cutting-edge medical technology . It is reported that Guangzhou Modern Hospital ( Stem Cell Research and Treatment Center ) is the first international hospital in stem cell research and application of authority .
 have a lot of clinical experience and exceptional treatment techniques for patients in various countries of Asia , especially in Indonesia patients with cirrhosis , diabetes , cerebral palsy and Parkinson’s to provide scientific methods and effective treatment .
Make a major contribution to medicine careers in Asia . The process of development of Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) relentless pursuit of medical technology . The doctors at the University of grants with a great knowledge of the conduct of traditional medicine .

A student from Jakarta with gusto after the visit , said : We do not just know the medical equipment and technology of international level , also felt enjoys an international hospital services over the medical services they provide . This is what we must learn from them . These exchanges will also attract local press media in Indonesia.

 

Pusat diakui oleh pemerintah dan universitas

 

[Indonesia]Pemerintah Provinsi DKI Jakart

23 Maret 2013, pemerintah provinsi di Jakarta, Menteri Luar Negeri Indonesia Bertemu Kelompok Persaudaraan China Ketua Lin Zhi Cheng. Kedua belah pihak persaudaraan Medical Group Investasi di Indonesia untuk membahas masalah kerjasama…[Baca selengkapnya]

 

Pemerintah Provinsi DKI Jakarta bertemu dengan Menteri Luar Negeri Gano dari “teman lama” China

23 Maret 2013, pemerintah provinsi di Jakarta, Indonesia, Menteri Luar Negeri di Berlin, Sura Hotel Gargano dipenuhi dengan “teman lama” China China Persaudaraan Ketua Kelompok Lin Cheng. Menteri Gano Lin Cheng menyambut kedatangan partainya dan investasi persaudaraan medis di Indonesia untuk membahas masalah kerjasama.

 

 

 

Ketua Lin Zhi Cheng terhadap Gano menteri pertama selama bertahun-tahun ketua Modern Hospital Guangzhou (Stem Cell Research and Treatment Center)

dalam mendukung dan bantuan yang diberikan oleh Kantor, mengungkapkan rasa terima kasih Indonesia.

 Lin Cheng Ketua mengatakan: China dan India menjalin hubungan diplomatik 60 tahun, hubungan kerjasama bersahabat bilateral telah dikembangkan dalam kerjasama medis pendalaman.

Pada awal tahun 2006, Rumah Sakit China Guangzhou persaudaraan Group Modern (Stem Cell Research and Treatment Center) tentang pembentukan kantor di Jakarta, mulai menghubungi rumah sakit setempat untuk pertukaran dan kerjasama.

 Inisiatif ini adalah ketika dia adalah presiden dari Angkatan Laut Rumah Sakit Umum Novo Coulee Umum Indonesia dihargai.

Selama bertahun-tahun, misi kantor adalah untuk

 “memberikan yang paling nyaman bagi kesehatan manusia, yang paling intim, pelayanan medis yang berkualitas tinggi,” misi perusahaan, menerima banyak diabetes ,  sirosis,  penyakit seperti cerebral palsy dan konsultasi pasien Parkinson , dan memberikan secara gratis program pengobatan.

 

Kantor juga diselenggarakan kesehatan berbicara berulang kali mempublikasikan pengetahuan berbagai penyakit pertahanan, sehingga lebih banyak orang belajar untuk mencegah penyakit di Indonesia, untuk menyingkirkan penyakit.

 

 

“Kesehatan Tanpa Batas, Cinta Tanpa Batas, Setiap layanan medis canggih harus dibagi kepada seluruh masyarakat dunia, kita harus berada di Asia Tenggara dan di seluruh dunia untuk mempromosikan pengembangan umum karir medis dan membuat setiap usaha. “Kata Lin Zhi Cheng dengan keyakinan dan semangat.

Menteri Gano terhadap hubungan persahabatan menyatakan penghargaan yang tinggi dan berkata,

“baik sekarang atau di masa depan, China Persaudaraan Grup adalah teman lama kami.”

Menteri Gano sungguh-sungguh berharap Kelompok persaudaraan untuk memperkuat kerjasama dengan rumah sakit nasional Indonesia, manfaat nyata dari dua orang!

 

Presiden rumah sakit Adi Husada Indonesia, Guo Shao Lin dan istri mendapat undangan berkunjung ke Guangzhou Modern Hospi

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Semenjak Guangzhou Modern Hospital (Pusat Penelitian dan Pengobatan Stem Sel) dirikan, tidak henti-hentinya bekerja sama dengan organisasi yang bersangkutan yang terkenal di dunia, melalui studi banding dan penelitian teknik, untuk mempertahan kan konsep kedokteran, pelayanan dan teknik yang canggih.

 

 

 

6 Juli, Presiden rumah sakit Adi Husada Indonesia, Guo Shao Lin dan istri mendapat undangan berkunjung ke Guangzhou Modern Hospital (Pusat Penelitian dan Pengobatan Stem Sel).

Dalam kunjungan, Guo Shao Lin menunjukkan kekaguman nya terhadap lingkungan dan pelayanan Guangzhou Modern Hospital (Pusat Penelitian dan Pengobatan Stem Sel).

Terakhir, Guo Shao Lin dan istri dengan dampingan staff pusat penelitian berjalan-jalan ke tempat wisata terkenal Guangzhou, “Bai Yun Shan”.

 

 

Universitas Erlangga Surabaya, Indonesia melakukan pertukaran akademik dengan para dokter pusat kami.

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Baru-baru ini, sekitar 40 dokter delegasi dari Universitas Erlangga Surabaya Indonesia, di departemen obat tradisional di bawah kepemimpinan orang yang bertanggung jawab ke Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) untuk pertukaran akademis .

Menurut pejabat departemen medis mengatakan, Jalur ini dipilih Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) sebagai tujuan akademis, ini didasarkan Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) pada kekuatan dan teknologi medis yang terdepan. Hal ini melaporkan bahwa Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) adalah rumah sakit internasional pertama dalam penelitian sel induk dan otoritas aplikasi.

 memiliki banyak pengalaman klinis dan teknik pengobatan yang luar biasa untuk pasien di berbagai negara Asia, terutama pasien di wilayah Indonesia dengan penyakit sirosis, diabetes, cerebral palsy dan parkinson untuk memberikan metode ilmiah dan pengobatan efektif.

Membuat kontribusi yang besar untuk karir pengobatan di Asia. Proses perkembangan Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) tanpa henti mengejar teknologi medis. Para dokter di Universitas Erlangga dengan pengetahuan yang besar melakukan pengobatan tradisional tersebut.

 

Seorang mahasiswa dari Jakarta dengan penuh semangat setelah kunjungan, berkata : Kita tidak hanya mengetahui peralatan medis dan teknologi tingkat internasional, juga merasa menikmati pelayanan rumah sakit bertaraf internasional atas pelayanan medis yang mereka berikan. Ini adalah apa yang harus kita pelajari dari mereka. Pertukaran ini juga akan menarik media pers lokal Indonesia.

 

Top of Form

[ Indonesia ] Indonesian Navy Chief meets with Chairman Kel >>>
Indonesia ] Indonesian Navy Chief meets with the Group Chairman Lin Cheng
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On March 27, Chief of Naval STAFF Staff met in Jakarta, Indonesia Suba medical fraternity Nuo China Enterprises Group Chairman Cheng Lin , the two sides held talks suave .

Chinese fraternity currently the largest private healthcare company in China.
For a long time , the Indonesian national medical institutions and medical fraternity China Enterprise Group maintain academic exchange and cooperation , especially in the Navy Indonesian military medical institutions and medical fraternity Enterprise Group has a very close cooperation .

 Indonesian military importance Navy has a deep friendship with the fraternal Chinese groups , in line with the best medical care with a patient approach , fully recommend fraternity Medical Group cooperation with China to benefit both patients .
At the meeting , Lin Cheng suggested that Guangzhou Medical Group in collaboration with Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) and the Indonesian Navy Hospital in the field of stem cell therapy .
Both sides in response to diabetes , liver cirrhosis , renal insufficiency , Parkinson’s disease and other common exchange of experience , according to co-operation and gradually move forward from the pilot areas of cooperation to expand wider . Suba Nuo Indonesia on behalf of the Department of the Navy General Staff and naval hospitals at all levels under the warm welcome Lin Cheng visited .
Lin Cheng Su Banuo strongly agreed with these recommendations .
Suba Nuo Lin Cheng chairman said the visit to Indonesia , has a very important significance , is expected to promote cooperation and development in the medical profession .
 Suba Nuo said that the Indonesian government or organization of health care organizations folk medicine military , medical cooperation will always form a group of nearby business with China as a good friend , I hope this friendship could be future cooperation and development in the process , continually deepened .
After the talks , Lin Cheng and Su Banuo exchange gifts symbolizes the traditional friendship .
 The audience applauded . Deputy Chief of General Staff of the Indonesian Navy Staff , political commissar of the Chinese Healthcare Enterprise Group Chairman Lin Cheng and his entourage attended the meeting together .


High-level leaders , Lin Zhi Cheng was invited to Cambodia >>>
[ Philippine ] Mayor of Manila , Alfredo Lin when he met the president of Bo Ai Group Lin Zhi Cheng >>>
[ Viet Nam ] The head of the health department of Hoan Kiem District Hanoi Vietnam , Nguyen Mai Huong Dao menginsp >>>
Engineering stem cells have been promoted to any country in Asia , making the patient more >>>
Vice president of the Philippines , Binay Bo Ai Group welcomes the president of China , Lin Zhi Cheng >>>
The center of the local hospital trust with the media

Indonesian delegation visited more than
Surabaya , Indonesia’s second largest city by the relevant authorities responsible for health care , Medical College Hospital , a large general hospital and the country is composed of more than 30 leaders in the field of medicine visit Mo. .. [ Read more ]
Indonesian delegation visited more than thirty hospitals and expand the exchange of experience and technology
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Indonesian national football captain Ronnie , the wife of the Minister of Indonesian society , child transport minister , and many other social officials and their families suffering from various diseases , multinational removed after treatment , finally chose to come to Guangzhou Modern Hospital Guangzhou to modern medicine , this is not a myth and legend , but because of the facts .
More recently , the second largest city officials in Surabaya , Indonesia, which is responsible for the relevant health care , Medical College Hospital , a large general hospital and the country is composed of more than 30 head of the line medical field exchange visits , gathered in the Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) .
Delegation condolences to the families of patients
May 8, 2010 , the city of Surabaya in Indonesia , 30 people from the local health authorities , a large general hospital Hospital Medical College and dean of the composition of the delegation came to visit Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) . From the city of Surabaya , the Dean of Medicine and hospital representatives Indonesia pictured with the head of Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) .
The Indonesian province of East Java , the medical association secretary , Mr Fu said that Sida Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) for treating diabetes , cirrhosis , renal dysfunction , Parkinson’s , many local hospitals are worth learning the application of this advanced treatment .
 Treatment methods and advanced technology , according to the different patients with different symptoms and diseases , implementation of different therapies , and achieved good results . Has a high reputation in the industry , and immediately well received by patients .

It is reported that , as of now , Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ) received more than 6,000 patients at home and abroad all kinds of people , among 95 % of patients , was sentenced only lasted two months . However , after referral to Modern Cancer Hospital Guangzhou , have received effective treatment , the survival of patients with advanced stage has been extended for six months to three years .


Bangladesh observed the reporter Tim Cave
21 September 2012 , a team of reporters that consists of a combination of some of the major mass media of Bangladesh came to observe the Guangzhou Modern Hospital ( Center for Research and Treatment of Stem Cells ) … [ Read more ]
Read More >>

Indonesian observation team visited the Guangzhou Modern Hospital ( pussy >>>

 

 

[Indonesia]Kepala Angkatan Laut Indonesia bertemu dengan Ketua Kel >>>

Indonesia]Kepala Angkatan Laut Indonesia bertemu dengan Ketua Kelompok Lin Cheng

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Pada tanggal 27 Maret Kepala STAF TNI Angkatan Laut Indonesia Staf bertemu di Jakarta Suba Nuo medis persaudaraan China Enterprises Ketua Kelompok Lin Cheng, kedua belah pihak mengadakan pembicaraan ramah tamah. 

 

Kelompok persaudaraan Cina saat perusahaan terbesar layanan kesehatan swasta China.

Untuk waktu yang lama, lembaga medis nasional Indonesia dan medis persaudaraan China Enterprise Group memper -tahankan pertukaran akademis dan kerjasama, khususnya di Angkatan Laut lembaga medis militer Indonesia dan medis persaudaraan Enterprise Group memiliki kerjasama yang sangat dekat.

 

 Pentingnya militer Angkatan Laut Indonesia memiliki persahabatan mendalam dengan persaudaraan Grup China, sejalan dengan yang terbaik pelayanan medis dengan pendekatan pasien, sepenuhnya merekomendasikan persaudaraan Medical Group kerjasama dengan Cina untuk menguntungkan kedua pasien.

Di dalam pertemuan, Lin Cheng menyarankan agar Guangzhou Medical Group bekerja sama dengan Modern Hospital Guangzhou (Stem Cell Research and Treatment Center) dan Rumah Sakit Angkatan Laut Indonesia di bidang terapi sel induk.

Kedua belah pihak dalam menanggapi diabetes, sirosis hati, insufisiensi ginjal, penyakit Parkinson dan pertukaran umum lainnya pengalaman, menurut kerjasama dan secara bertahap bergerak maju dari daerah percontohan kerjasama untuk memperluas yang lebih luas. Suba Nuo Indonesia Angkatan Laut atas nama Departemen Staf Umum dan rumah sakit angkatan laut di semua tingkat di bawah sambutan hangat Lin Cheng dikunjungi.

Lin Cheng Su Banuo sangat setuju dengan rekomendasi tersebut.

Suba Nuo mengatakan kunjungan ketua Lin Cheng ke Indonesia, memiliki makna yang sangat penting, diharapkan akan meningkatkan kerjasama dan pengembangan dalam profesi medis.

 Suba Nuo mengatakan bahwa baik pemerintah Indonesia atau organisasi perawatan organisasi obat rakyat kesehatan militer, kerjasama medis akan selalu membentuk kelompok bisnis terdekat dengan China sebagai teman baik, saya berharap persahabatan ini bisa menjadi kerjasama masa depan dan pengembangan dalam proses, terus-menerus diperdalam. 

Setelah pembicaraan, Lin Cheng dan Su Banuo bertukar hadiah melambangkan persahabatan tradisional.

 Para penonton bertepuk tangan meriah. Jenderal Wakil Kepala Staf Angkatan Laut Indonesia Staf, komisaris politik dari Cina Healthcare Enterprise Group Ketua Lin Cheng dan rombongan menghadiri pertemuan tersebut bersama-sama.

 

Pemimpin tingkat tinggi, Lin Zhi Cheng diundang ke Kamboja >>>

Pusat kepercayaan rumah sakit setempat dengan media

 

Delegasi Indonesia mengunjungi lebih dari

Surabaya, kota terbesar kedua di Indonesia oleh pejabat terkait yang bertanggung jawab atas perawatan kesehatan, Medical College Hospital, sebuah rumah sakit umum besar dan negara terdiri dari lebih dari 30 pemimpin di bidang kedokteran mengunjungi Mo..[Baca selengkapnya]

Delegasi Indonesia mengunjungi lebih dari tiga puluh rumah sakit dan memperluas pertukaran pengalaman dan teknologi

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Kapten sepakbola nasional Indonesia Ronnie, istri Menteri masyarakat Indonesia, anak menteri transportasi, dan banyak pejabat sosial lainnya dan keluarga mereka menderita berbagai penyakit, setelah perawatan multinasional dihapus, akhirnya memilih untuk datang ke Guangzhou Modern Hospital Guangzhou untuk pengobatan modern, ini bukan mitos dan legenda, tapi karena fakta-fakta.

Baru-baru ini, pejabat kota terbesar kedua di Surabaya, Indonesia yang bertanggung jawab atas perawatan kesehatan yang relevan, Medical College Hospital, sebuah rumah sakit umum besar dan negara terdiri dari lebih dari 30 kepala garis bidang medis melakukan kunjungan pertukaran, berkumpul di Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center ).

Delegasi belasungkawa kepada keluarga pasien

8 Mei 2010, kota Surabaya di Indonesia, 30 orang dari otoritas kesehatan setempat, rumah sakit umum besar Hospital Medical College dan dekan komposisi delegasi datang mengunjungi Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center). Dari kota Surabaya, Dekan Kedokteran dan perwakilan rumah sakit Indonesia berfoto dengan kepala Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center).

Provinsi di Indonesia Jawa Timur, sekretaris asosiasi medis, Mr Sida Fu mengatakan bahwa Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center) untuk mengobati diabetes, sirosis, disfungsi ginjal, Parkinson, banyak rumah sakit setempat patut belajar penerapan pengobatan canggih ini.

 Metode pengobatan dan teknologi canggih ini, sesuai dengan pasien yang berbeda dengan gejala dan penyakit yang berbeda, pelaksanaan terapi yang berbeda, dan mencapai hasil yang baik. Memiliki reputasi tinggi dalam industri ini, dan langsung diterima dengan baik oleh pasien.

 

Hal ini melaporkan bahwa, seperti yang sekarang, Modern Hospital Guangzhou ( Stem Cell Research and Treatment Center) menerima lebih dari 6.000 pasien di dalam dan di luar negeri semua jenis orang, diantara 95% dari pasien, divonis hanya bertahan dua bulan. Namun, setelah dirujuk ke Modern Cancer Hospital Guangzhou, telah menerima pengobatan yang efektif, kelangsungan hidup pasien dengan stadium lanjut telah diperpanjang untuk enam bulan sampai tiga tahun.

 

 

 

Tim wartawan Bangladesh mengobservasi Gua

21 September 2012, tim wartawan yang terdiri dari gabungan beberapa media masssa utama Bangladesh datang mengobservasi Guangzhou Modern Hospital (Pusat Penelitian dan Pengobatan Stem Sel)…[Baca selengkapnya]

Baca Lebih Lanjut >>

Tim observasi Indonesia mengunjungi Guangzhou Modern Hospital (pus >>>

Driwan Stem Cell Therapy Information Center (intro)

Driwan Stem Cell therapy

Information Center

Introduction

By

Dr Iwan Suwandy,MHA

Copyright @ 2014

 

 

FOUNDER
 
Dr Iwan Suwandy,MHA
more infocontact
iwansuwandygmail.com
all free of charge
this info to all human in the world
with
 
THE MIGHTY GOD BLESS
 
 

 

 

 

 

 

 

 

 

This project dedicated

To ny family

Especially from my grand daughter

Anabella Tifanny  Pricessa (Cessa)

And MY Grandson Antoni William Suwandy

In hoping they will continiue this project’

In the future

For helping the human life against

All kinds of disease which

The power of Stem Cell

which created by The GOD

through

the human Scholars

 

 

 

INTRODUCTION

During studies of new terapy for Diabetic rype2 Nephropathy, I found many information at Referencese study about Stem Cell Terapy.

I think thisStem cell Terapy must studies and created in the laboratoirum ,after that we must making many

Clinical trail as soon as possible,

But this are not my knowledge area,

Due to this reason I will promoting

This gen biotechnology  Stem Cell terapy

In my web blog Driwancybermuseum

With name Driwan Stem Cell Project Promotion

With hoping my own grandson and grand daughter with all new generation will starting to learn

And will make the imterest to built

 The Stem Cell terapy Studies

For helping the human who need

This  amazing and miracle terapy,

also helping everybody who need informations

related to this therapy, I will put the informations everday one by one and  I hope many communications and discussion which making this new therapy more knowing by everybody who need the information related to to this therapy

please contact me

the coordinator of

The Stem Cell Therapy Information Centers Project

Through email

iwansuwandy@gmail.com

Jakarta February 2014

Dr Iwan suwandy,MHA

 

BENCANA TERBESAR DI ASIA BUKAN DI INDONESIA

BENCANA ALAM TERBESAR DIASIA

 BUKAN TERJADI DI INDONESIA

OLEH

Dr Iwan Suwandy,MHA

Copyright @ 2014

 

PENDAHULUAN

Baru saja terjadi bencana alam berupa letusan Gunung Kelud dengan dampak yang cukup berat yang melumpuhkan beberapa lapangan terbang di Jawa tengah dan jawa Timur akibat debu vulkanis, kejadian ini relative lebih ringan dari letusan Gunung kelud tempo9 dulu sehingga abu vulkanisnya  menutup hamper seluruh jawa tengah teramsuk candi Borobudur tertimbun sampai hilang dari pandangan mata, hal ini mengakibatkan terjadilah perpindahan Kerajaan Jawa ke Jawa Timur mulai dari kerajaan Kediri, Airlangga,Singosari, kemudian jadi Mojopahit dan seterusnya yang hamper seluruh rakyat Indonesia pasti sudah mengetahuinya karena di tulis dalam buku-buku sejarah yang dipelajari di sekolah.

Apakah letusan Gunung berapi di Indonesia ,yang terkenal dengan Ring Of Fire ,merupakan kejadian bencana Alam terbesar di Asia ?

Bencana Alam Indonesia tersebut seperti letusan gunun g Krakatau,Gunung Tambora, dan sebagainya,serta gempa tektonis dengan pergeseran lempeng bumi di Indonesia dengan timbulnua Tsunami pada tahun 2006 yang lalu dan tentunya juga pada masa yang lalu. Ternyata bukanlah bencana yang terbesar yang telah kita ketahui bersama ,

Ternyata ada bencana Alam yang terbesar di Asia tetapi tidak menimbulkan bencana yang sama di Indonesia, hal ini saya belum pernah pelajari di buku-buku sekolah, padahal bencana Alam terbesar di Asia Barat tersebut menimbulkan dampak yang luar biasa terhadap Negara local bencana tersebut,

Kemudian setelah Bencana tersebut  itu  timbul dampak sosio ekonomi besar akibat migrasi penduduk Negara terlibat Bencana kearah Asia Timur termasuk Indonesia  dan hal ini  sangat berpengaruh terhadap perkembangan etnis penduduk Indonesi yang selama ini sulit diketahui mengapa kita Indonesia multi etnis and multi religious.

Kejadian ini perlu kita ketahui dan pelajari agar kejadian ini bila terjadi kita semua akan siap untuk menghadapinya,sesuai motto saya  dalam mepelajari sejarah

Learn From The Past

Alam terkembang Jadi Guru

Kejadian Bencana besar di Asia Barat tersebut terkenal dengan istilah

The Great Famine of 843 (90 AD)

INDIA MONSSON

Dimana terjadi perubahan cuaca ekstreem berupa angin badai yang memberikan dampak luar biasa

Untuk mengetahui informasi lebih lanjut silahkan membaca buku elektronik Dr Iwan

Yang berjudul

 

BENCANA ALAM TERBESAR DIASIA

 BUKAN TERJADI DI INDONESIA

 

Agar dapat menambah informasi, bagi yang belum memiliki buku elektronik ini saya upload sebagian contoh dari buku tersebut,bagi yang berminat dapat menghubngi saya liwat email

iwansuwandy@gmail.com

Jakarta
February 2014

Dr Iwan Suwandy,MHA

 

 

 

The Great Famine of 843 (90 AD)

 

 

India Monsoon  Onset Map 

monsun

adalah serangkaian angin yang membawa awan lembab yang basah kuyup di wilayah  India dan Asia tenggara selatan  dari tanggal terjadinya Monsoons di anak benua India .

Ini tterjadi pada tahun 843 ( 90 AD ) . Asia dalam hujan selama musim panas .

Pola cuaca ini sangat sensitif dan rentan terhadap perubahan lingkungan .

tahun 2013 terjadi lagi monsson di India

Pada musim panas tahun 843 ( 90 AD )

musim hujan tidak datang di Asia Tenggara dan orang-orang dari Nan(Vietnam) serta Sriwijaya jatuh ke kelaparan .

Pada saat yang sama

gurun Utara Sinica(China)

mulai mengirim

badai pasir besar jauh di luar gurun daripada yang pernah mereka capai sebelumnya, yang juga chocked banyak lembah-lembah sungai Sinica .

Kematian yang terjadi secara besar-besaran dan diperkuat bahkan lebih oleh kenyataan bahwa ia datang pada akhir waktu yang lama dan berkelanjutan perdamaian antara kekuatan Asia Timur .

Satu-satunya daerah yang agak Tidak terkena dampak   oleh perkembangan ini adalah pulau-pulau Indonesia dari Sriwijaya , yang banyak dari anggota yang lebih kaya dari masyarakat mereka melarikan diri ke setelah meninggalkan benua , serta wilayah paling timur dari Dinasti Han Kedua dan koloni Jepang .

 

Sriwijaya adalah , untuk sebagian besar orang Tiongkok  terlalu  jauh bagi omereka  untuk menjangkaunya  .

 

Orang-orang sekarat dari apa yang dilagukan

oleh

 

dinasti Tang pindah Timur.

Kematian yang dikelilingi orang-orang Sinica(Tiongkok) begitu besar bahwa itu menjadi

topik cerita novel pertama dari seorang anak muda kehilangan orang tuanya untuk perjalanan pindah yang panjang

ke kota Shanghai untuk mencari makanan dan masa depan .

Setiap uang yang bisa diambil dari orang-orang yang bepergian adalah , ketidakmampuan mereka untuk pergi setelah mereka kehabisan uang menyebabkan banyak untuk menetap di sekitar orang terkaya yang bisa mengatur pergerakan makanan .

 

Kota-kota baru dimulai pada rute bergerak ke Timur tumbuh menjadi pusat perdagangan setelah hujan kembali dan daerah Barat yang cocok untuk repopulation .

Contoh-contoh ini tertiup pergi praktis oleh kejadian-kejadian

di Mongolia di mana

Jepang diperbudak

banyak orang berimigrasi ke pertanian dan tenaga kerja industri , dan hampir semua dari mereka menyetujui perbudakan .

Langkah untuk merebut kembali

bagian-bagian Mongolia

dari Asia Utara oleh Jepang disambut tanpa perlawanan oleh pimpinan Mongolia yang akan menyapa setiap penghuni yang bisa menawarkan mereka makanan .

Perlakuan Jepang adalah keras tapi mereka membawa mereka akses ke beras dan tanah-tanah penggembalaan ternak mereka .

 

Orang Jepang dan Sinicans memiliki banjir rekrutan baru untuk militer mereka yang merupakan salah satu dari beberapa bentuk sisa terhormat pekerjaan belum dilibatkan dalam pengendalian serikat buruh melindungi karir seperti pembuatan kertas untuk diri mereka sendiri dan keluarga mereka .  

Peta Dunia di sekitar Samudra Hindia setelah Kelaparan Mahahebat dari 843 ( 90 AD ) .

 Merah: Maurya Empire , Orange: Kekaisaran Romawi , Hijau : Sriwijaya Empire , Light Blue : Parthia Empire , Blue: Ethiopia Raya , Purple : Satavahana Raya paling tidak ada pertahanan di perbatasan mereka dengan mundurnya tentara kembali ke pulau-pulau .

 Sriwijaya namun dari tanah diplomatik perusahaan dengan Kekaisaran lainnya .

Gerakan berikutnya di Benua Asia dalam menanggapi musim hujan berada di negara yang paling dipengaruhi oleh siklus monsoon, India .

Orang-orang Indian memulai kampanye migrasi untuk mencari makanan dan uang .

Apa cadangan sukses Maurya Kekaisaran telah pergi ke kapal-kapal tersebut yang mulai menjelajahi Samudera Hindia dan mengontrolnya sehingga mereka dapat memperoleh makanan dari daerah yang lebih subur .

Langkah pertama dibuat oleh sebuah keluarga kaya dari seluruh Andhra Coast.

Mereka dikirim oleh Samraat ( Kaisar ) Brihadrata II ke Pantai Timur Afrika di mana mereka bertemu Kerajaan Ethiopia yang menjadi mitra dalam perdagangan gandum .

 Selain itu , keluarga yang dikirim ke Afrika , bernama Satavahana , mendirikan Kerajaan mereka sendiri di pulau tak berpenghuni dari Madagaskar dan area yang lebih kecil di pantai Tenggara , dengan nama keluarga mereka .

Cabang kedua dari eksplorasi untuk makanan India pergi ke pulau-pulau dari Kekaisaran Sriwijaya .

 Banyak berimigrasi di sana dan meninggalkan masa lalu mereka di Maurya Empire belakang .

Kemudian , keluarga lanjut dikirim untuk memberikan India kontrol atas wilayah-wilayah yang subur dan mengembalikan imigran ke pemerintahan Kaisar tersinggung .

 Banyak dari keluarga berimigrasi adalah bagian dari keluarga Sunga yang telah mencoba untuk mendirikan pemerintahan mereka sendiri , karena mereka brahmana dan dalam agama Hindu diyakini mereka ditakdirkan untuk memerintah atas orang lain .

Mereka dikalahkan oleh putra Samraat Brihadrata pertama , bernama Dakshesh , dan dianggap sebagai bagian dari kasta hamba yang menyamar kasta yang lebih tinggi

 

 

 

 

 

Original info

The monsoons

are a series of winds that bring in moist clouds that drench the areas of India and SoutheastA picture of the onset dates of Monsoons in the Indian Subcontinent. These did not occur in the year 843 (90 AD).Asia in rain during the Summer.

These weather patterns are very sensitive and vulnerable to changes in the environment. In the summer of the year 843 (90 AD)

the monsoons did not arrive in Southeast Asia and the people of Nan as well as Srivijaya fell into famine.

 

At the same time the deserts of Northern Sinica began to send great sandstorms further outside the desert than they had ever reached before, which also chocked many of the river valleys of Sinica.

The death that ensued was massive and amplified even more so by the fact that it came at the end of a time of long and sustained peace between the powers of East Asia.

The only areas that were rather uneffected by these developments were the Indonesian islands of Srivijaya, which many of the wealthier members of their society fled to after leaving the continent, as well as the Easternmost areas of the Second Han Dynasty and the Japanese Colonies.

The Srivijaya were, for the most part, to far for people from Sinica to reach them.

 

The dying people of

what was So

Song and Tang moved East.

The death that surrounded the people of Sinica was so great

 

that it became the topic of the first novel story of a young boy losing his parents to a long move to the the city of Shanghai to find food and a future.

Any money that could be extracted from the traveling people was, the inability of them to leave after they ran out of money led many to settle around the richest person who could orchestrate the movement of food.

 

These new cities were started on routes moving to the East grew into trading centers once the rains returned and the Western areas were suitable for repopulation.

These examples were blown away practically by the events in Mongolia where the Japanese enslaved many of the immigrating people into farm and industrial labor, and almost all of them consented to the enslavement.

The move to retake the Mongolian parts of North Asia by the Japanese was met without resistance by the leadership of Mongolia who would greet any occupier who could offer them food.

The treatment of the Japanese was harsh but they brought them access to rice and to grazing land for their cattle.

The Japanese and the Sinicans had a flood of new recruits to their military which was one of the few respectable remaining forms of employment not already entangled in the control of trade guilds protecting careers like paper making for themselves and their families.

The Srivijaya had aim

 

The World around the Indian Ocean after the Great Famine of 843 (90 AD).

 Red: Maurya Empire, Orange: Roman Empire, Green: Srivijaya Empire, Light Blue: Parthian Empire, Blue: Ethiopian Kingdom, Purple: Satavahana Kingdom most no defenses on their borders with the retreat of the soldiers back to the islands.

 

 

 Srivijaya was however of a firm diplomatic ground with the other Empires.

The next movement in the Asian Continent in response to the monsoons was in the country that was most effected by monsoon cycle, India.

The Indians began a campaign of migration in search of food and money. What reserves the successful Maurya Empire had went to these ships that began to explore the Indian Ocean and to control it so that they can gain food from more fertile areas.

The first move was made by a wealthy family from around the Andhra Coast.

They were sent by the Samraat (Emperor) Brihadrata II to the East Coast of Africa where they encountered the Kingdom of Ethiopia which became a partner in the trade of grain.

 Furthermore, the family sent to Africa, named the Satavahana, established their own Kingdom in the uninhabited island of Madagascar and a smaller area on the Southeast coast, under their families name.

The second branch of the Indian exploration for food went to the islands of the Srivijaya Empire.

 Many immigrated there and left their pasts in the Mauryan Empire behind.

Later, further families were sent in order to give India control over these fertile regions and to return the immigrants to the rule of the offended Emperor.

 

 

 Many of these immigrating families were part of the Sunga family which had tried to establish their own rule, because they were brahmins and in the Hindu religion believed themselves destined to reign over others.

They were defeated by the son of Samraat Brihadrata the first, named Dakshesh, and were regarded as part of the servant caste that had impersonated a higher caste

2nd  Century

desa Sang Hyang Dengdek 31 km dari kota padeglang

.

 di kampung Cipurut,

 

Situs Sang Hyang Dengdek

 

Sanghyang Dengdek ”Sang Hyang Dengdek” atau yang mempunyai nama “ Prabu Jayasati Wisesa” adalah arca laki-laki dan Sanghyang Heuleut atau “Mas Ratu Lenglang Jagad” adalah arca perempuannya

Situs Batu Goong – Citaman

 

 

 

 

 

 near ancient telaga

 

situs Cihunjuran

diduga kuat sebagai tempat persinggahan atau peristirhatan

 

 

 Angling Dharma

 yang kemudian membangun Kerajaan Salakanagara.

 

Selain itu juga terdapat makam Angling Darma yang mempunyai gelar “Aki Jangkung”.

 

Konon Aki Jangkung ini atau yang mempunyai nama ”Kyai Prabu Raja Angling Darma Kusuma” membuat kerajaan di tepi Gunung Pulosari ini Sebagai tempat peristirahatannya.

 

 

Dan kolam pemandian cihunjuran ini merupakan tempat penyempurnaan dari segala ritual yang dilakukan oleh Angling Darma dan pernah juga dipakai oleh Sultan Hasanudin. Berdasarkan nasakah Pustaka Rajyarajya I Bhumi Nusantara” (disusun oleh sebuah panitia diketuai Pangeran Wangsa Kerta)

 

 

130-150 AD

 

.

Rudradaman I (r. 130–150) was a Saka ruler from the Western Kshatrapas dynasty.

He was the grandson of the celebrated Sah[1] king Chastana.

 

 Rudradaman I was instrumental in the decline of the Satavahana Empire.

 

after he became the king and then strengthened his kingdom. During his reign he married a Hindu woman and converted to Hinduism

Kingdom of Salakapura

Start in 130 A.D.

King .Dewawarman I  until VIII

3rd Century

However, in the 3rd century the warlike Yaudheyas became more powerful.

 The indigenous Nagas also were aggressiv toward 

Saka kshatrapas

 in the 3rd century.

The Satavahanas

In the 3rd century CE the empire was split into smaller states

 

 

 

 

 

According to the data of China Koying were trading

in the 3rd century AD

Pasemah

also in South Sumatra and Lampung Ranau area

 has found indications of trading activities undertaken by Tonkin or Tongkin and Vietnam or Fu – nan in the same century . Instead of tiles Han dynasty ( 2nd century BC to 2nd century AD ) found in a particular region of Sumatra .

 

Candi muara Jambi

 

 

 

 

 

4TH CENTURY AD

Considered one of the oldest archaeological sites in Malay, it is dated to the 4th Century A.D. This is, without question, a Hindu and Buddhist site, with over 50 temples (or chandis) so far excavated.

These artifacts, dating to the 4th Century A.D. include pottery shards, stone statues of Hindu icons, inscribedc stone tables, metal tools, Song and Ming Dynasties ceramic wares, ornaments, beads and semi precious stones.

Kedah was the transit port for traders (awaiting the monsoon winds) traveling through the Melaka straits. Kedah Peak was used as a navigational beacon for th

ese traders, and the settlement grew into a kingdom from this trade route. Most structures are believed to be of wooden pillars, thus the remains found here are mainly foundations of the chandi structures.

While the earliest date is the 4th Century A.D., the area flourished in the 7th Century A.D. and was eventually replaced by the Malacca kingdom in the 11th Century A.D. This Hindu-Budha temple dates to around the 8th to 10th Century A.D.

 

Kota Gelanggi

 

 is one of the oldest pre-Islamic Malay Kingdoms of

 

 South East Asia’s Malay Peninsula.

The oldest archaeological site in Malay, and the first capital of the ancient Malay Empire of Srivijaya, dates to around 650 A.D. to 900 A.D. It is located in the dense jungles of

 the southern Malaysian state of Johor at Darul Takzim

Explore this 150 million year old historical and mythical caves complex and witness its unique flora, fauna and its magnificent rock formations which will definitely captivate you.

 

With cave chambers dubbed to be one of the best in this region, Kota Gelanggi Caves offers an inspiring and breathtaking adventure experience.

 

 Indulge in the myths behind these caves and explore the wonderful works of nature through beautiful rock formations sculptured by time.

 

 

 Legend has it that these caves were actually ancient ruins of inhabitants who were turned into stones together with their belongings. .

 

 Drop by and witness these wonders yourself and experience the beauty of the stalagmites and stalactites as well as the unique and strangely shaped rock formations. All crafted with fitness by the time and nature.

 

 

4th Century

358

Salakanagara later replace by

 Tarumanegara dynasty

the road to the Candi “Jiwa” (Ancient Soul -BudhishTemple), after enter the Rengasdengklok ,from the Jakarta Cikampek Toll Road, at West Cikampek I foun dthe sign

 

,then tern left and after the railways t’s turn to the right,

I came to the very crowded market

Then the turn right until at then of that market

,turn left near the small river, I drive straight until arrived the sign

 

, the Jiwa Temple at the right circa 40 km in very bad road,with very small arrow directions of Candi Jiwa , then turn to the right about 500 m.

 

 

 

I enter the broken candi Jiwa, and with the helping of the native peoples there I have seen other borken candi, they talled me about 24 candi beside Candi Jiwa there.

 

 

 

All the candi built frome “Bata” sands break.

please look my profile at two candi Jiwa at Batujaya krawang west Java

 

 

LOOK THE COMPLETE INFO AT

THE CHINESE KAPITAN PART TWO C

THE CHINESE EMMINENT RELIC BEFORE SRIVIJAYA

 

 

Several events from the 4th to 6th centuries

 

mark the transitional period during which the Roman Empire’s east and west divided.

In 285,

 

 

 The emperor Diocletian (r. 284–305)

 

 

partitioned the Roman Empire’s administration into eastern and western halves.[3] 

Between 324 and 330

 

,Constantine I (r. 306–337)

transferred the main capital from Rome to Byzantium, later known as Constantinople (“City of Constantine”) andNova Roma (“New Rome”).[n 1] 

 

 

Under 

 

 

Theodosius I (r. 379–395),

 Christianity became the Empire’s official state religion and others such asRoman polytheism were proscribed.

And finally,

 under

 

the reign of Heraclius (r. 610–641),

the Empire’s military and administration were restructured and adopted Greek for official use instead of Latin.[5]

 

 

 

 In summary,

 while it maintained Roman state traditions, Byzantium is distinguished from ancient Rome proper insofar as it was oriented towards Greek rather than Latin culture, and characterised by

 

 

 Orthodox Christianity 

 

 

 

 

rather than

 

 

 Roman polytheism.[6]

 

The borders of the Empire evolved significantly over its existence, as it went through several cycles of decline and recovery.

 

 

 

 

During

 

 

the reign of

 

 

Justinian I (r. 527–565),

the Empire reached its greatest extent after reconquering much of the historically Roman western Mediterraneancoast, including north Africa, Italy, and Rome itself, which it held for two more centuries.

During

 

the reign of

 

 

 Maurice (r. 582–602),

the Empire’s eastern frontier was expanded and the north stabilised.

 

However, his assassination caused a two-decade-long war with 

 

 

 

Sassanid Persia

 

 which exhausted the Empire’s resources and contributed to major territorial losses during the Muslim conquests of the 7th century.

 

 

 

 

Dr Iwan Noteas

In 2011 I found

 

The Queen Sasanid silver coin

in Bukittinggi west Sumatra

The Iran  Sasanid kindom during

 

Empress Puran 7th Century,

bring by Gujarat Trader during Srivijaya empire in Indonesia and they had trading with the Minangkabau marchant at Mingkabau Kingdom (Pagaruyung),( The first report found in Indonesia-auth,anoher report from Rusia)

 

 

 

Gujarat trader

 

The Chinese records

 

give a graphic picture of the long trade routes across their country,

 

 

 

around the south of the Gobi desert,

 

to the Oxus River,

 

 

 into

 

Parthia

 

and on to

 

Mesopotamia.

 

 

 

 

 

 

 

 

 

An alternate route was by sea from

 

 Canton,

 

 

 

around

 

the Malay peninsula

 

 

, pass

 

 the southern tip of India

 

 

 and into

 

 the Persian Gulf.

 

Yule writes, “At this time, (early fifth century)

 

the Euphrates

 

 

was navigable

 

as high as Hira,

 

a city lying

 

southwest of ancient Babylon …

 

 

and the ships of India and China were constantly to be seen moored before the houses of the town.”38

 

The Chinese either turned their goods,

 

 

 chiefly silks,

 

 over to the Arabs here, or over to the Parthians at the Oxus River, the latter then bringing them to Hira.

 

 

There they were transshipped around

 

the Arabian peninsula,

 up

 

the Red Sea

 

 

to

 

 

Solomon’s Ezion-geber

 

 

Or

 

 the Aelana (modern Akabah) of the Romans;

from there

 

 caravans carried them

 

 

 to

 

Petra, the great market city,

 

 

to sell them to

 

the western traders.

 

 

 

Ancient Chinese traders

 

 

 

 

Of Petra Hirth writes:

During the first two centuries A D.,

 

Petra

 

or Rekem,

was the great emporium of Indian (and, we may add, Chinese) commodities, where merchants from all parts of the world met for the purpose of traffic…. Under the auspices of Rome, Petra rose, along with her dependencies, to an incredible opulence….

 This prosperity was entirely dependent upon the caravan trade, which at this entrepot changed carriage, and passed from the hands of the southern to those of the northern merchants.39

6th Century

Around the year 500,

Srivijayan roots began to develop around present day 

 Palembang, 

Sumatra,

in modern Indonesia.

The empire was organised in three main zones — the estuarine capital region centred on Palembang, the Musi River basin which served as hinterland and rival estuarine areas capable of forming rival power centres.

The areas upstream of the Musi River were rich in various commodities valuable to Chinese traders.[16] 

The capital was administered directly by the ruler while the hinterland remained under its own local datus or chiefs, who were organized into a network of alliances with the Srivijaya maharaja or king. Force was the dominant element in the empire’s relations with rival river systems such as Batang Hari, centred in Jambi

 

 

 

7th Century

 

 

605

The country of Fu-lin, also called Ta-ts’in, lies above the western sea. In the southeast it borders on Po-ssu (Persia)…. The emperor Yang-ti of the Sui dynasty (A.D. 605-617) always wished to open intercourse with Fu-lin, but did not succeed.

 

The several accounts known in Chinese literature of the mysterious country in the west called Fu-lin is declared to be identical with the country from ancient times known as Ta-ts’in.

This is known from the texts of the T’ang dynasty, which use the two names are interchangeable terms.

It has been concluded by the Chinese that Ta-ts’in is Syria, and if that is the case, then Fu-lin must be Syria.

The author is disinclined to be guided by this kind of logic. Friedrich Hirth believes that Ta-ts’in is the Roman empire.

However the detail placed on record in the contemporary Chinese texts is confined to its Asiatic provinces, for which reason Antioch is described as the capital city.

 

 Hirth considers Fu-lin to be Byzantium and Ta-ts’in to be certain Asiatic portions of the empire.

 After this analysis, there still remain quite a number of important points to be settled in connection with both Ta-ts’in and Fu-lin

The Byzantine Empire was the predominantly Greek-speaking continuation of the Roman Empire during Late Antiquity and the Middle Ages.

 

 

Its capital city was Constantinople

 

 

(modern-day Istanbul), originally known as Byzantium. Initially the eastern half of the Roman Empire (often called the Eastern Roman Empire in this context),  it survived the 5th century 

 

 

fragmentation   

 

 and fall of the Western Roman Empire

and continued to exist for an additional thousand years until it fell to the Ottoman Turks in 1453.

. Both “Byzantine Empire” and “Eastern Roman Empire” are historiographical terms applied in later centuries; its citizens continued to refer to their empire as the Roma Empire (Ancient Greek: Βασιλεία Ῥωμαίων, tr.Basileia Rhōmaiōn; Latin: Imperium Romanum),[1] and Romania (Ῥωμανία).[2]

 

c.616 CE:

 

The maternal uncle of the prophet Muhammad, Abu Waqqas, joined a trading voyage from Ethiopia to Guangzhou. He then returned to Arabia, and came back to Guangzhou 21 years later with a copy of the Koran.

 

He founded the Mosque of Remembrance,

 

near the Kwang Ta (Smooth Minaret) built by the Arabs as a lighthouse.

 

Abu Waqqas tomb is in the Muslim cemetery in Guangzhou.

 

 

 

 

 

 

 

 


Liu Chih,

The Life of the Prophet (12 vols), 1721, quoted by the Islamic Council of Victoria, http://www.icv.org.au/history2.shtml
Four missionaries were sent to China by the prophet Mohammad, and two died in Quanzhou.

 

 

 They were buried as honoured guests, and the tombs repeatedly repaired and embellished until the present.
Wang Lianmao (ed),
Return to the City of Light, p.99, and Quanzhou site captions, citing Ming Shu, ‘A history of Fujian province

Chinese influence in Islamic pottery

`

 

 

 

 

 

 

618

Tang Dynasty

The death of

 

Emperor Yang Ti of Sui

 

resulted in a Sui Kingdom civil war from which

 

King Li Yuan (of Western Wei) later became

 

the first Tang Emperor Kao Tsu

and

 

his son Li Shih-min arose victorious,

 

establishing the T’ang dynasty and extending the unification of China for another 300 years. Li Yuan, adopting the title

 

 

T’ang Kao Tsu, ruled from AD 618-626

 

 

then abdicated in favor of his son Li Shih-min who adopted the title

 

T’ai Tsung and ruled from AD 627 to 649.

Both were able rules under whom T’ang began its rise to greatness. The next 300 years was a time of relative calm, prosperity and enlightenment with the cultural arts dominating over the military arts.

 

 

 

 

 

636

During the patriarchate of Syrian missionaries

 

Mar Ishu Jahb II, 636,

 

 went to China, and for 150 years this mission was active…. 109 Syrian missionaries have worked in China during 150 years of the Chinese mission….

They went out from Beth Nahrin, the birthplace of Abraham, the father of all believers.

The Syrian missionaries traveled on foot;

 they had sandals on their feet, and a staff in their hands, and carried a basket on their backs, and in the basket was the Holy Write and the cross.

They took the road around the Persian Gulf; went over deep rivers and high mountains, thousands of miles. On their way they met many heathen nations and preached to them the gospel of Christ.20

 

 

 

 

 

LOOK  COMPLETE INFORMATION AT

THE BOOK

BYFOOT TO CHINA

During the early years of the Mohammedan regime,

 the Syrian Christian churches had more freedom and peace than under the Persian kings.

A concordat was signed with Mohammed whereby the Christians would pay tribute, in time of war shelter endangered Muslims and refrain from helping the enemy.

In exchange they were to be given religious toleration, though they were not to proselytize, and they would not be required to fight for Mohammed.21

He had reason to be friend the Christians for a “Nestorian” had been Mohammed’s teacher at one point and, in some early battles, certain Christian communities had actually fought on his side against pagan tribes.22

So much Christian influence, though highly distorted, is apparent in his teaching that Islam has been called a Christian heresy

 

 

 

 

 

It was not until the seventh century that two events brought about the demise of this great trading center.

The first was

 

the smuggling of silkmoth eggs

 

 

 into Syria, concealed in a bamboo cane,

 

 

 

the presumption being that it was done by “Nestorians,”40 with the result that “by the end of the sixth century (Syria) appears to have been meeting the west’s demand for the raw material.”41

The Chronology Srivijaya History Collections

Distorted history of Southeast Asia in Śrīvijaya times

At the beginning of the twenty-first century, few people doubt that the location of the Śrīvijaya was Palembang in Sumatra, because, according to G. Coedès, Palembang was the center of the trade between the East and West in the Śrīvijaya times as well as that of Mahāyāna Buddhism.

However it is quite dubious if the hypotheses reflect historical facts or not. As the entrepôt between India and China, Jambi was located at more preferable location than Palembang.

As the center of Mahāyāna Buddhism, the states of Malay Peninsula, such as Chaiya had more advantage than Palembang.

5th Century

According to the Chinese annals, Funan and Pan-pan were known where Mahāyāna Buddhism flourished since the fifth century and contributed to China in the field of Buddhism.So, when the anboy of Srivijaya, the Tan court gave them the name of ‘室利佛逝Shi-li-fo-shi). This name includes the Buddha (佛). This means special treatment for Srivijaya.

In the history of Śrīvijaya, the role of Palembang was too exaggerated, as the result the ancient history of Southeast Asia has been distorted.

For instance the trade relation between China and Indonesia (Java and Sumatra) was not so developed before the seventh century. Even the inscription was rare before the seventh century in the central Java.

The ancient Chinese courts preferred the Indian, Arabic and Persian goods as well as the products of Southeast Asia, such as incense woods and ivories.

The Java Island was not in the position to get the western goods easily, compared with Funan and Champa. Funan obtained them mainly at the port of Takua Pa and carried them through the land route to Chaiya. From Chaiya, Funan shipped them to its own port, ‘Oc-Eo’ and directly China and Champa. Chaiya and Champa maintained good relations for long time.

Historically from very ancient times,

Indian people and their cultural influences came to Southeast Asia in successive waves. The details of them cannot be discussed here.

However the first migrant group came to Southeast Asia as treasury hunters. They primarily looked for gold and other precious things. They found several gold mines in this area, for instance Pahang in the middle of the Malay Peninsula. The Indian migrants brought beads and cotton clothes to exchange with gold and daily necessities from indigenous people.

605

605

Little physical evidence of Srivijaya remains.[13] According to the Kedukan Bukit Inscription, dated 605 Saka (683 CE), the empire of Srivijaya was founded by Dapunta Hyang Çri Yacanaca (Dapunta Hyang Sri Jayanasa). He led 20,000 troops and 312 people in boats with 1312 foot soldiers from Minanga Tamwan to Jambi and Palembang.

Although according to this inscription, Srivijaya was first established in the vicinity of today’s Palembang, it mentions that Dapunta Hyang came from Minanga Tamwan. The exact location of Minanga Tamwan is still a subject of discussion.

 

 

The Kedukan Bukit Inscription was discovered by the Dutchman M. Batenburg on 29 November 1920 at Kedukan Bukit, South Sumatra, on the banks of the River Tatang, a tributary of the River Musi. Barring the potentially earlier (but undated) Dong Yen Chau inscription, it is the oldest surviving specimen of the Malay language, in a form known as Old Malay. It is a small stone of 45 by 80 cm. This inscription is dated the year 605 Saka (683 AD) and contains numerous Sanskrit words

Original Text in Old Malay Language

All these inscriptions were written in Pallava script, a form of ancient script used in Tamil kingdoms of ancient India.

Transliteration 1:

svasti śrī śakavaŕşātīta 605 (604?) ekādaśī śu-

klapakşa vulan vaiśākha ḍapunta hiya<ṃ> nāyik di

sāmvau mangalap siddhayātra di saptamī śuklapakşa

vulan jyeşţha ḍapunta hiya<ṃ> maŕlapas dari minānga

tāmvan mamāva yaṃ vala dualakşa dangan ko-

duaratus cāra di sāmvau dangan jālan sarivu

tlurātus sapulu dua vañakña dātaṃ di mata jap

sukhacitta di pañcamī śuklapakşa vula<n> <…>

laghu mudita dātaṃ marvuat vanua <…>

śrīvijaya jaya siddhayātra subhikşa <…>

Transliteration 2:[1]

Swasti Shri Shakawarsatita 605 ekadashi

Shuklapaksa wulan Waishaka dapunta hiyang naik

Disambau mangalap siddhayatra di Saptami Shuklapaksa

Wulan Jyestha dapunta hiyang marlapas dari Minanga

Tamvan (Tamvar?) mamawa jang bala dua laksa dangan <…>

dua ratus tsyara disambau dangan jalan saribu

Tlu ratus sapuloh dua banyaknya. Datang di Matajap (Mataya?)

Sukhatshitta. Di pantshami shuklapaksa Wulan <…>

Laghu mudik datang marwuat manua <…>

Syriwijaya jayasiddhayatra subhiksa.

Translation in Malay Language[edit]

Literal translation:

Selamat dan Bahagia. Dalam Syaka 605

Sebelas hari Bulan Waisyaka. Baginda naik kapal

Mencari untungnya pada tujuh hari

Bulan Jyestha, Baginda berlepas dari Muara

Tamvan membawa bala dua laksa dengan <…>

Dua ratus pawang di kapal dengan jalan seribu

Tiga ratus sepuluh dua banyaknya. Datang di Matajap

Sukacita. Di lima hari Bulan <…>

Belayar mudik datang membuat benua <…>

Srivijaya kota yang jaya, bahagia dan makmur.

 

Detailed translation:

Salam bahagia, batu bersurat ini ditulis pada hari ke-11 bulan Waisyaka Tahun 605 Syaka:

Baginda menaiki kapal untuk mencari untungnya pada 7 hari di bulan Jyestha.

Baginda berlepas dari Muara Tamvan dengan membawa dua puluh ribu bala

dengan <…> serta dua ratus pawang dan tentera sebanyak

seribu tiga ratus dua belas banyaknya dengan sukacitanya datang ke Matajap.

Pada lima haribulan <…>, mereka datang belayar mudik ke hulu untuk membuka negara <…>.

Srivijaya, kota yang jaya, bahagia dan makmur.

English Translation for Malay Language version of the Inscription[edit]

All hail and prosperity! In the year 605 of the Saka calendar, on the eleventh

day on the full moon of Waisaka, His Majesty took

a boat to make a profit. On the seventh day

on the full moon of Jyesta, His Majesty

brings 20000 troops and

312 people in boats from firth of Tamvan, With 1312 foot soldiers

and came to Matajap

happily. On the fifth day on the bright moon of …,

they docked and open a country …

Great, prosperous and peaceful Srivijaya!

English Translation[edit]

Om swasti astu! All hail and prosperity. In the year 605 of the [Indian] Saka calendar, on the eleventh day at half-moon of Waisaka, Sri Baginda took dugouts in order to obtain siddhayatra.[2] On Day 7, on the 15th day at half-moon of Jyestha, Sri Baginda extricated himself from minānga tāmvan.[3] He took 20,000 troops with him … as many as 200 in dugouts, with 1,312 foot soldiers. They arrived at … Truly merry on the fifteenth day of the half-moon…, agile, happy, and they made a trip to the country … Great Sriwijaya! Prosperity and riches …”

 

 

 

680

Under the leadership of Jayanasa, the kingdom of Malayu became the first kingdom to be integrated into the Srivijayan Empire. This possibly occurred in the 680s. Malayu, also known as Jambi, rich in gold and was held in high esteem. Srivijaya recognized that the submission of Malayu would increase its own prestige.[18]

 

The Palembang theory as the place where Srivijaya was first established, was presented by Coedes and supported by Pierre-Yves Manguin. Soekmono on the other hand, argues that Palembang is not the capital of Srivijaya and suggests that the Kampar river system in Riau where the Muara Takus temple is located as Minanga Tamwan.[14] Another theory suggests that Dapunta Hyang came from the east coast of the Malay Peninsula, and suggests Chaiya as the center of Srivijaya.[15]

680 AD

 

This possibly occurred in the 680s.

Malayu, also known as Jambi,

rich in gold and was held in high esteem.

Srivijaya recognized that the submission of Malayu would increase its own prestige.[18]

 

 

 

682 CE:

Kedukan Bukit Inscription

The first known inscription of a king of Srivijaya was incised on a river boulder at Kedukan Bukit, Palembang in Sumatra.
Stuart Munro-Hay, Nakhon Sri Thammarat, 1.6.

 

683 AD

Little physical evidence of Srivijaya remains.[13]

According to the Kedukan Bukit Inscription, dated 605 Saka (683 CE), the empire of Srivijaya was founded by Dapunta Hyang Çri Yacanaca (Dapunta Hyang Sri Jayanasa). He led 20,000 troops and 312 people in boats with 1312 foot soldiers from Minanga Tamwan to Jambi and Palembang.

Although according to this inscription, Srivijaya was first established in the vicinity of today’s Palembang, it mentions that Dapunta Hyang came from Minanga Tamwan.

The exact location of Minanga Tamwan

 is still a subject of discussion.

The Palembang theory as the place where Srivijaya was first established, was presented by Coedes and supported by Pierre-Yves Manguin. Soekmono on the other hand, argues that Palembang is not the capital of Srivijaya and suggests that the Kampar river system in Riau where theMuara Takus temple is located as Minanga Tamwan.[14] 

Another theory suggests that Dapunta Hyang came from the east coast of the Malay Peninsula, and suggests Chaiya as the center of Srivijaya.[15]

684

From Sanskrit inscriptions, it’s notable that the King Jayanasa launched a maritime conquest in 684 with 20,000 men to acquire wealth, power, and ‘magic power’.[17] 

Under the leadership of Jayanasa, thekingdom of Malayu became the first kingdom to be integrated into the Srivijayan Empire.

the end of the third quarter of 7th century,

According to Chinese sources by the end of the third quarter of 7th century, became the leader of an Arab merchant Muslim Arab settlements on the coast of Sumatra. Islam also gives effect to the existing political institutions

684

From Sanskrit inscriptions, it’s notable that the King Jayanasa launched a maritime conquest in 684 with 20,000 men to acquire wealth, power, and ‘magic power’.[17]

693

According to the Kota Kapur Inscription, discovered on Bangka Island, the empire conquered most of Southern Sumatra and the neighboring island of Bangka, as far as Lampung.

Also according to the inscription, Jayanasa launched a military campaign against Bhumi Java in the late 7th century, a period which coincides with the decline of Tarumanagara in West Java and Holing (Kalingga) in Central Java. The empire thus grew to control the trade on the Strait of Malacca, the Sunda Strait, the South China Sea, the Java Sea, and the Karimata Strait

Chinese records dating to the late 7th century

mention two Sumatran kingdoms, as well as three other kingdoms on Java as part of Srivijaya.

By the end of the 8th century,

many western Javanese kingdoms, such as Tarumanagara and Holing, were within the Srivijayan sphere of influence. It has also been recorded that a Buddhist family related to Srivijaya dominated central Java at that time.[19] The family was probably the Sailendras.[20] The ruling lineage of Srivijaya intermarried with the Sailendras of Central Java and lived along the Javanese Sanjaya dynasty when the Srivijayan capital was located in Java.

During the same century, Langkasuka on the Malay Peninsula became part of Srivijaya.[21] Soon after this, Pan Pan and Trambralinga, which were located north of Langkasuka, came under Srivijayan influence. These kingdoms on the peninsula were major trading nations that transported goods across the peninsula’s isthmus.

With the expansion into Java and the Malay Peninsula, Srivijaya controlled two major trade choke points in Southeast Asia. Some Srivijayan temple ruins are observable in Thailand and Cambodia.

The area of Chaiya, in Surat Thani Province, Thailand, was already inhabited in prehistoric times by Semang and Malayan tribes. Founded in the 3rd century, the Srivijaya kingdom dominated the Malay Peninsula and much of the island of Java from there until the 13th century.

 

The city of Chaiya‘s name may be derived from its original Malay name “Cahaya” (meaning ‘light’, ‘gleam’ or ‘glow’). However, some scholars believe that Chai-ya probably comes from Sri-vi-ja-ya. It was a regional capital in the Srivijaya empire of the 5th to 13th century. Some Thai historians argue it was the capital of Srivijaya itself, but this is generally discounted.

 

At some point in the 7th century,

Cham ports in eastern Indochina started to attract traders. This diverted the flow of trade from Srivijaya. In an effort to divert the flow, the Srivijayan king or maharaja, Dharmasetu, launched various raids against the coastal cities of Indochina.

 

8th  CENTURY

723

the Sundan king which became the Mataram and Majapahit King


Sanjaya

( Rakeyan Jamri / Prabu Harisdama,)

The second Sunda King

(723 – 732M),

Became the King of Mataram K8ingdom(732-860 AD(

 and he found the Ancient Mataram kingdom and also the  Sandjaja Reign

menjadi raja di Kerajaan Mataram (Hindu) (732 – 760M).

 Ia adalah pendiri Kerajaan Mataram Kuno, dan sekaligus pendiri Wangsa Sanjaya

 


Kompleks Candi Dieng

Kompleks candi-candi Hindu yang dibangun pada abad ke-7, antara lain: Candi Gatotkaca, Candi Bima, Candi Arjuna, Candi Semar, Candi Sembadra, Candi Srikandi, Candi Setyaki, Gangsiran Aswatama, dan Candi Dwarawati.

Kawasan ini terletak sekitar 26 km di sebelah Utara ibukota Kabupaten Wonosobo, dengan ketinggian mencapai 6000 kaki atau 2.093 m di atas permukaan laut. Suhu di Dieng sejuk mendekati dingin. Temperatur berkisar 15—20°C di siang hari dan 10°C di malam hari. Bahkan, suhu udara terkadang dapat mencapai 0°C di pagi hari, terutama antara Juli—Agustus. Penduduk setempat menyebut suhu ekstrem itu sebagai bun upas yang artinya “embun racun” karena embun ini menyebabkan kerusakan pada tanaman pertanian.

Nama Dieng berasal dari bahasa Sunda Kuna “Di” yang berarti “tempat” atau “gunung” dan “Hyang” yang bermakna (Dewa). Dengan demikian, Dieng berarti daerah pegunungan tempat para dewa dan dewi bersemayam. Nama Dieng berasal dari Bahasa Sunda karena diperkirakan sebelum tahun 600 daerah itu didiami oleh Suku Sunda dan bukan Suku Jawa.

 

 

732:

Sanjaya dynasty founded around this time according to Canggal inscription.[11]

8th century to 832: The agriculturally-based Buddhist Sailendra kingdom flourishes and declines.[11]

 

 

732

Again, “In the ninth month of the twentieth year K’ai-yuan (October 732) the king of Persia sent the chief Pan-na-mi (Barnubi) with the monk of great virtue, Chi-lieh (Cyriacus) as ambassadors with tribute.”62 But these casual references are too numerous to mention further. The evidence of the presence of the “Nestorian” missionaries in China during the T’ang era is incontestable. On the basis of the Chinese records alone Hirth states dogmatically, “all the first embassies sent from Fu-tin during the T’ang dynasty were carried out by Nestorian missionaries.”63

In Japan and Korea also, evidence of a past early Christian presence survives. Two beams of an ancient temple, dating from the late seventh century, with crosses on them and having inscriptions identified by professor Sayce as being “in an alphabet akin to Syriac,”64 are in the Tokyo National Museum. In northwest Japan is a large tomb, dating from about the same time, known to the local people as “the tomb of Jesus.” In all probability it is the tomb of a “Nestorian” Christian who preached Jesus, perhaps even bore His name, who was buried there in the tomb period.

Balaputradewa

seorang raja dari Kerajaan Sriwijaya. Balaputradewa memerintah pada abad VIII-IX masehi. Balaputradewa adalah raja yang paling terkenal dari Kerajaan Sriwijaya karena di masa pemerintahan beliaulah Kerajaan Sriwijaya mencapai puncak kejayaannya sebagai sebuah Kerajaan Maritime yang berkuasa hampir diseluruh Nusantara hingga mencapai Thailand, India, Filipina dan China.

Look the Museum Balaputra  dewa

 

Museum Balaputradewa terletak di Km 6,5 tepatnya di Jl. Srijaya Negara I No. 288, Palembang, Sumatera Selatan, Indonesia.

Museum Balaputradewa memiliki sekitar 3580 buah koleksi yang terdiri dari barang-barang tradisional Palembang, binatang awetan dari berbagai daerah di Sumatera Selatan, beberapa miniature rumah pedalaman, replica prasasti dari arca kuno yang pernah ditemukan di Bukit Siguntang, batu-batu ukir raksasa dari jaman Megalitikum, dan masih banyak lagi.

 

 

 

 

 

Koleksi di Museum Balaputradewa dibagi menjadi 10 macam kategori yaitu

 histografi atau historika (cerita-cerita),

 etnografi,

feologi,

keramik,

alat-alat teknologi modern,

seni rupa (berupa ukiran),

 flora fauna (biologika) dan geologi

serta terdapat rumah limas juga rumah Ulu Ali.

Koleksi-koleksi di Museum Balaputradewa ditempatkan pada 3 buah ruang pameran yang dikelompokan menjadi

ruang pamer zaman prasejarah,

 

 

 

Putri cave

 

 

 

 

 

 

Pasemah fossil

 

 

 

Stone axe

 

 

 

Burial eathern martavan

 

Stone inscription

 

 

 

 

 

 

 

 

 

 

Museum srivijaya at palembang

732

The Sailendras and the Sanjayas

From the beginning, a tension developed in central Java between competing Buddhist and Hindu ruling families.

 The first central-Javanese temples and inscriptions, dating from 732 A.D.,

were the work of a Hindu ruler by the name of Sanjaya.Very soon thereafter, however, a Budhist line of kings known as the Sailendras (Lords of the Mountain) seem to have comefrom the north coast of Java to impose their rule over Sanjaya and his descendants.

The Sailendras maintained close relations with Sriwijaya (both rulers were Buddhist) and ruled Java for about 100 years.

 During this relatively short period they constructed the magnificent Buddhist monuments of Borobudur, Mendut, Kalasan, Sewu and many others in the shadow of majestic Mt. Merapi. Still now this area is blessed with unusually fertile soils, and already in ancient times it must have supported a vast population, who all participated in the erection of these state monuments.

 

 

Plaosan temple

 


The statue of Durga Mahisasuramardini in northern cella of Shiva temple,

Prambanan temple complex in Central Java. Also called Durga Loro Jonggrang
Candi (pronounced /
ˈtʃandiː/) are commonly refer to Hindu and Buddhist temples
or sanctuaries in Indonesia, most of which were built from the 8th to the 15th centuries.

 

 However, ancient non-religious structures such as gates, habitation remnants, or pool and bathplaces are often also called as “candi”…The term “candi” itself derived from Candika one of the manifestation of the goddess Durga as the goddess of death.[Soekmono, Dr R. (1973). Pengantar Sejarah Kebudayaan Indonesia 2. Yogyakarta, Indonesia: Penerbit Kanisius. pp. 81.] This suggested in ancient Indonesia the “candi” has mortuary function as well as attributed with the afterlife. The association of the name “candi”, candika or durga with Hindu-Buddhist temples is unknown in India and other Indonesia’s Southeast Asian neighbours such as Cambodia, Thailand, or Burma.

 

 The historians suggested that temples of ancient Java also used to store the ashes of cremated deceased kings or royalties.

 

This is also in-line with buddhist concept of stupa as the structure to store buddhist relicts including the ashes and remnants of holy buddhist priest or the buddhist king, the patron of buddhism. The statue of god stored inside the garbhagriha (main chamber) of the temple often modelled after the deceased king and considered as deified self of the king portrayed as Vishnu or Shiva.

 

The Prambanan compound also known as Loro Jonggrang complex,

 

 named after the popular legend of Loro Jonggrang. There are 237 temples in this Shivaite temple complex, either big or small…The middle zone consists of four rows of 224 individual small shrines.

 

There are great numbers of these temples, but most of them are still in ruins and only some have been reconstructed. These concentric rows of temples were made in identical design. Each row towards the center is slightly elevated.

 

 These shrines are called “Candi Perwara” guardian or complementary temples,

 

the additional buildings of the main temple. Some believed it was offered to the king as a sign of submission. The Perwara are arranged in four rows around the central temples, some believed it has something to do with four castes, made according to the rank of the people allowed to enter them; the row nearest to the central compound was accessible to the priests only, the other three were reserved for the nobles, the knights, and the simple people respectively.

 While another believed that the four rows of Perwara has nothing to do with four castes, it just simply made as meditation place for priests and as worship place for devotees.

736

The Shoku-Nihongi, published in 797, refers to the return from China in 736 of an envoy who brought with him “a Persian by the name of Limitsi and another dignitary of the church of the Luminous Religion (Kei Kyo-Chinese, Ching Chiao) called Kohfu.”65

Elsewhere in Japanese history the Persian is referred to as Rimitsu, the physician. The Empress Komyo was very much influenced by his teaching and later built a hospital, an orphanage and a leprosarium, works of mercy typical of the “Nestorian” practical Christianity, but not of the Buddhism of that day.

One of the most sacred objects of the Shingon sect of Buddhism at the Nishi-Honganji Temple in Kyoto, founded by Kobo Daishi after he returned in 806 from China’s capital and contact with the “Nestorian” monastery there, is a copy of the early missionary manuscript, “The Lord of the Universe’s Discourse on Almsgiving,” a commentary on the Sermon on the Mount and other Matthew passages. It is said that Shiriran spent hours daily studying this Christian document

 

 745:

Arrival of Islam in the archipelago

 was first marked in the invention Batu Nisan Sandai Sandai, Ketapang territory of the Kingdom Tanjungpura bertarikh 127 Hijri (745 AD).

a Chinese monk,

 I-Tsing,

wrote that he visited…

 ruled Sumatra, the Malay peninsula, and western Java (Sunda)

sīlĕnˈdrä,

sīlĕnˈdrä,

name of a dynasty in Indonesia and SE Asia.

The dynasty appeared in central Java in the 7th cent. and had consolidated its position by the mid-8th cent appeared in central Java in the 7th cent. and had consolidated its position by the mid-8th cent.

The Sailendras, who adopted Buddhism,

extended their power over the Sumatran domains of Sri Vijaya and the Malay Peninsula and exerted influence in Siam and Indochina

 

752 to 1045:

 The Hindu Medang (Mataram) kingdom flourishes and declines.[12]

 

 

760 to 830:

 

Borobudur Buddhist monument constructed.[13]

 

748 CE: Chinese monk Jian Zhen (Jianzhou, of Daming monastery in Yangzhou), failed in his fifth attempt to sail to Japan, and drifted to Guangzhou where ‘many big ships came from Borneo, Persia, Qunglun [Indonesia/Java]… with… spices, pearls and jade piled up mountain high’. The largest ship looked like a mansion, with sails many zhangs high. [1 zhang = 3.11 metres.] Sri Lanka was by now the major shipping centre, with ships visiting from India, Persia and Ethiopia; Sri Lankan ships had gangways many zhangs high.
Tang Zhiba, ‘The influence of the sail on the development of the ancient navy’, p.61

 

The Tang Dynasty (Chinese: 唐朝; Mandarin Pinyin: Táng Cháo; Jyutping: tong4 ciu4; IPA: [tʰɑ̌ŋ tʂʰɑ̌ʊ]; Middle Chinese: Dâng) (618 – 907 AD) was an imperial dynasty of China preceded by the Sui Dynasty and followed by the Five Dynasties and Ten Kingdoms period. It was founded by the Li () family, who seized power during the decline and collapse of the Sui Empire. The dynasty was interrupted briefly when Empress Wu Zetian seized the throne proclaiming the Second Zhou Dynasty (October 8, 690 – March 3, 705) and becoming the only Chinese empress regnant.

 

 

The 7th century and first half of the 8th century is generally considered the zenith era of the Tang Dynasty. Emperor Tang Xuanzong brought the Middle Kingdom to its golden age while the Silk Road thrived, with sway over Indochina in the south, and to the west Tang China was master of the Pamirs (modern-day Tajikistan) and protector of Kashmir bordering Persia.[48]

 

Some of the kingdoms paying tribute to the Tang Dynasty included Kashmir, Nepal, Khotan, Kucha, Kashgar, Japan, Korea, Champa, and kingdoms located in Amu Darya and Syr Darya valley.[49][50]

There was great contact and interest in India as a hub for Buddhist knowledge, with famous travelers such as Xuanzang (d. 664) visiting the South Asian subcontinent.

After a 17-year long trip, Xuanzang managed to bring back valuable Sanskrit texts to be translated into Chinese. There was also a Turkic–Chinese dictionary available for serious scholars and students, while Turkic folksongs gave inspiration to some Chinese poetry.[103][104] In the interior of China, trade was facilitated by the Grand Canal and the Tang government’s rationalization of the greater canal system that reduced costs of transporting grain and other commodities.[105] The state also managed roughly 32,100 km (19,900 mi) of postal service routes by horse or boat.[106]

During the Tang Dynasty, thousands of foreigners came and lived in numerous Chinese cities for trade and commercial ties with China, including Persians, Arabs, Hindu Indians, Malays, Sinhalese, Khmers, Chams, Jews and Nestorian Christians of the Near East, and many others.[115][116] In 748,

the Buddhist monk Jian Zhen described Guangzhou as a bustling mercantile center where many large and impressive foreign ships came to dock. He wrote that “many big ships came from Borneo, Persia, Qunglun (Indonesia/Java)…with…spices, pearls, and jade piled up mountain high”,[117][118]

 

The Kwan Sing Bio Temple

is located in Tuban Regency, the city lying in the north coast of East Java.
It is also easy to reach by public transport such as bus or car since its strategic position close to the Surabaya and Jakarta main road, or take only a short walk about two hundred metres from the Tuban bus terminal.

The worship place of Kwan Sing Bio temple is predicted to have been built in the seventh century and it was also believed to have high supernatural quality, therefore lots of Hindu pilgrims visite there daily, especially on holidays of Chinese calendar Imlek and the birthday of Kwan Ping Thai Tjoe, Kwan Sing Tee Koen, and Tjoe pjong Tiang Koen. The temple faces northward to the seashore.

 

 

 

 

 

 

 

The Indonesian Chinese communities believe that God will easily grant every prayer spelt in this direction. One of its uniqueness is the giant crab standing on the gateway, and such a kind of this is away from the custom since most of the temples have symbol of dragon and peacock.

The  Belitung Shipwreck Tang Dynasty  Collection

 

Created by

Dr Iwan suwandy,MHA

Copyright@2014

 

 

 

1.The very rare and excellent Tang Dinasty ceramic s and other gold cup were found at the Belitung straits , but very pitty Indonesia fishermen only found the bad conditions collections, all the best collection were gone to Singapore Museum and trader.

 

2.Due to that condition I starting to seek the info about that collections via google explorations and show to all the Chinese Tang’s  Ceramic collector all over the world.

 

3. I hope this info will help the Indonesia and all over the world marine archeologist will used this info fore their research

 

 

 

 

 

 

 

The Gaspar Strait runs between the Indonesian islands of Bangka and Belitung, some 300 miles southeast of Singapore, where I sit today, writing these words.

Its calm, blue surface belies the snarl of rocks and reefs beneath, and the so-called Belitung Wreck is just one of many ships that met its demise in these perilous waters.

In 1998,

a German prospector by the name of Tilman Walterfang dove into the strait and struck gold: or rather, some gold, silver, and lots of pots.

Over the year, his prospecting company pulled 60,000 handmade artifacts out of the heavily silted waters in the Gaspar, from the wreck of a large ship that we now know sunk sometime in the ninth century.

Its contents, known vaguely as ‘the Tang treasure’, have been said to enlarge forever the boundaries of our knowledge of Chinese Tang dynasty maritime history and of the nature and dimensions of early Asian trade.

 

 

 

For the next six years or so,

the treasure languished in a New Zealand warehouse, while Qatar, Shanghai, Singapore and private collectors all vied vigorously for ownership.

In 2005,

Singapore bought the lot. And this afternoon, I had the good fortune to be taken for a private tour of it.

Junks and their junk

The vessel that sunk was likely a dhow of Arab or Indian origin, a conjecture substantiated well by Michael Flecker, an archaeologist who was invited by Tilman Walterfang himself to direct and document the excavation.

 

 

 

(Some of Flecker’s academic papers on the topic, as well as a fascinating but brief clip of part of the excavation, can be found here).

 

According to Flecker, one of the most striking features of the dhow is that it was not held together with nails or dowels, but sewn together, likely with coconut-husk fibers. Its probable destination is also well established. In the world of the ninth century, dominated economically by two imperial giants

 

 

— Tang Dynasty China

and

 

Abbasid Persia —

 

the ship has been reasonably thought to be sailing from one to the other, probably

 

 

 

 

 

 from

 

Guangzhou

 

To

 

 

 Basra.

 

 

Basra silver coin

 The vessel is purported to be the first of Middle Eastern origin found in Southeast Asian waters.

 

Singapore, alas, didn’t acquire the actual ship, so I didn’t get to see it. We saw the Tang treasure instead.

 

 

 

At present,

most of it is housed in an unassuming basement at the bottom of

the Hua Song Museum in Singapore.

The place looked to me, as I walked in this evening, a little like a bomb shelter.

 

What strikes you almost as soon as you walk into the warehouse is the sheer scale of production.

It seems that China then, as now, was mass producing and exporting their goods in staggering quantities — several centuries earlier than scholars have previously thought.

You might say that in the hold of this sunken ship lurked, for 1200 years, a kind of ancient Ikea.

 

The serial nature of most of the cargo, and the fact that the ceramics exhibit styles distinct to at least five different kilns from all over China, both seem to suggest that this was an export vessel.

Of particular interest is the enormous quantity of mint-condition Changsha pottery, a form of Southern Tang ceramic readily identified by its distinctive brown and straw-coloured glaze.

 

 

 

 

The Changsha specimens found in the Belitung wreck

are decorated with an enormous range of motifs. There is something for everyone: lotuses, makara fish and Chinese calligraphy for the Buddhists, invocations of Allah and non-pictorial, geometric patterns for the Muslims, and everything in between.

These are not terribly valuable in and of themselves; they are, as Simon Worrall’s droll appraisal in his article in National Geographic goes,

“the Tang equivalent of Fiestaware”.

762 CE:

The Abbasid caliph Al-Mansur founded a new capital at Baghdad: a carefully chosen site to which, an advisor noted, supplies would come up the Tigris river in ships from China and India.
Abu Ja’far Muhammad Al-Tabari (839-923), ‘The History of Al-Tabari’, cited in Amira Bennison, ‘The Great Caliphs’, p.69

 

766-804 CE:

China had very large river and canal boats, estimated at 700 tons. ‘The crews of these ships lived on board; they were born, married and died there. The ships had… lanes (between the dwellings), and even gardens. Each one had several hundred sailors… South to Chiangsi and north to Huainan they made one journey in each direction every year, with great profit….. The sea-going junks (hai-po) are foreign ships. Every year they come to Canton and An-i. Those from Ceylon are the largest…When these ships go to sea, they take with them white pigeons, so that in case of shipwreck the birds can return with messages.’
Michael L.Bosworth, http://www.cronab.demon.co.uk/china.htm, citing Joseph Needham Vol. 4 Part III, p.452-3 (Cambridge Univ Press, 1971), which in turn quotes Tang Yu Lin’s Tang Yu Lin (Miscellanea of the Tang Dynasty), compiled in the Song dynasty.

785-805 CE: Chinese merchant ships sailing from Guangzhou were calling regularly at Sufala on the east African coast, to cut out Arab middlemen.
Shen Fuwei, Cultural flow between China and the outside world, p.155,

786-809 CE: A diplomatic present of exquisite Chinese porcelain to Caliph Harun al Rashid of Baghdad caused a sensation at that court.
Shen Fuwei, Cultural flow between China and the outside world, p.163.

 

774 CE:

 Javanese attacked Champa, destroying the Po Nagar temple at Nha Trang.
Emmanuel Guillon, Cham Art, p.195

 

921

Prasasti Sukabumi itu, tertera angka tahun 921 M.

 

 

 

Di situ diceritakan soal pembangunan bendungan dan sungai yang dimulai pertama kali pada 804 M.

Prasasti Sukabumi adalah sebuah prasasti pada batu

yang ditemukan di perkebunan Sukabumi, kecamatan Pare, Kediri, Jawa Timur.

 

Prasasti ini menurut sebutan ahli epigrafi lebih dikenal dengan nama Prasasti Harinjing.

 

Tulisan yang terdapat pada kedua belah sisi prasasti ini ditulis dengan aksara dan bahasa Jawa Kuna.

 

Prasasti ini terdiri dari tiga buah piagam yang mengenai hal yang sama.

 

 

Bagian depan disebut Prasasti Harinjing A.

Isinya menyebutkan pada 11 Suklapaksa bulan Caitra tahun 726 Saka atau 25 Maret 804 Masehi, para pendeta di daerah Culangi memperoleh hak sima (tanah yang dilindungi) atas daerah mereka karena telah berjasa membuat sebuah saluran sungai bernama Harinjing.

Bagian belakang, Prasasti Harinjing B,

baris 1-23 menyebutkan bahwa Sri Maharaja Rake Layang Dyah Tulodhong pada 15 Suklapaksa bulan Asuji tahun 843 Saka atau 19 September 921 Masehi, mengakui hak-hak para pendeta di Culangi karena mereka masih tetap harus memelihara saluran Harinjing.

Mulai baris selanjutnya, disebut Prasasti Harinjing C,

 

 menyebutkan bahwa hak serupa diakui pula pada 1 Suklapaksa bulan Caitra tahun 849 Saka atau 7 Maret 927 Masehi.

.

 

khuluk_BABAT_JAWA.

1563

Terjadi bencana besar di Euro yang terkenal dengan

The Black Death

dan

dampak negatif dan positif yang timbul 

 

Ternyata Bencana besar akhirnya terjadi juga

di Indonesia

yaitu tahun

1586

 sehingga runtuhnya kerajaan majapahit

 

Yoh, Kediri mbesuk bakal pethuk piwalesku sing makaping-kaping, yaiku Kediri bakal dadi kali, Blitar dadi latar, lan Tulungagung dadi kedung” ~Lembu Sura~

– Kalimat di atas adalah “sepatan” alias kutukan yang diucapkan Lembu Sura, tokoh legenda yang mewarnai sejarah Kabupaten Kediri di Jawa Timur. Juga, sejarah kerajaan Majapahit.

Ada beragam versi soal Lembu Sura yang berakhir dengan kutukan dan menjadi sejarah lisan kehadiran Gunung Kelud ini.

Meski demikian, semua bertutur tentang cara seorang perempuan cantik menolak lamaran Lembu Sura.

Satu versi, adalah cerita dengan

perempuan cantik Dewi Kilisuci yang adalah anak Jenggolo Manik.

Versi lain, ini adalah kisah tentang

 

Dyah Ayu Pusparani, putri dari Raja Brawijaya, penguasa tahta Majapahit. Ada versi-versi lain tetapi inti cerita sama.

Kisah ini bermula dari kecantikan yang tersohor, mendatangkan para pelamar, sayangnya yang datang tak sesuai harapan. Tak enak menolak, maka cara sulit diterapkan. Tak beda dengan kisah Rorojonggrang dan legenda candi Prambanan.

Namun, dalam legenda Gunung Kelud, pelamar sang putri ini masih pula bukan manusia.

 Dia makhluk berkepala lembu.

Itulah Lembu Sura.

Untuk menolak lamaran Lembu Sura, dibuatlah syarat pembuatan sumur sangat dalam hanya dalam waktu semalam.

Tak dinyana, Lembu Sura ini punya kekuatan dan kemampuan untuk mewujudkan syarat itu.

Melihat perkembangan tak menggembirakan, sang putri pun menangis.

Ayahnya, dalam versi kisah yang mana pun, kemudian memerintahkan para prajurit untuk menimbun Lembu Sura yang masih terus menggali di sumur persyaratan itu.

Batu demi batu dimasukkan ke lubang sumur, menjadi sebentuk bukit menyembul karena ada Lembu Sura di dalamnya.

Saat batu dilemparkan, Lembu Sura masih memohon untuk tak ditimbun. 

Begitu menyadari bahwa permohonannya akan sia-sia, keluarlah “sepatan” sebagaimana menjadi kutipan di atas.

 

Yoh, Kediri mbesuk bakal pethuk piwalesku sing makaping-kaping, yaiku Kediri bakal dadi kali, Blitar dadi latar, lan Tulungagung dadi kedung

~Lembu Sura~

 Sejak saat itulah legenda Gunung Kelud dan kedahsyatan letusan maupun dampaknya mengemuka.

 

1586

Hancurnya Majapahit

Terlepas dari mitos Lembu Sura, tiga wilayah yang disebut dalam kutukannya itu memang kemudian luluh lantak. Para ahli sejarah memperkirakan letusan pada1586 yang menewaskan lebih dari 10.000 orang adalah akhir dari sejarah kekuasaan Kerajaan Majapahit.

Betul, catatan sejarah menyebutkan Kerajaan Majapahit diperkirakan runtuh pada kisaran angka tahun 1478.

 Namun, para sejarawan hari ini pun mengakui masih banyak yang belum terkuak soal sejarah kerajaan itu, seperti misalnya dugaan ada dua Majapahit pada satu masa.

Apa kaitannya dengan Gunung Kelud?

Tentu saja letusannya.

 

Peta rawan bencana letusan Gunung Kelud, yang dirilis Badan Geologi Kementerian Energi, Sumber Daya Alam, dan Mineral menyusul peningkatan status kegunungapian Gunung Kelud menjadi Awas, Kamis (13/2/2014) malam.

 

 Gunung ini kembali meletus pada Kamis dengan letusan pertama terjadi pada pukul 22.50 WIB.

 

Sebelum letusan pada 2007,

setidaknya sejak awal abad 1900-an

 diketahui bahwa kawah Gunung Kelud memiliki danau.

Kecuali letusan pada 2007, letusannya pun diketahui bertipe eksplosif, termasuk letusan pada Kamis (13/2/2014) malam.

Dalam sebuah wawancara mantan Kepala Pusat Vulkanologi dan Mitigasi Bencana Geologi (PVMBG) Badan Geologi Kementerian Energi, Sumber Daya Alam, dan Mineral (ESDM) Surono mengatakan keberadaan danau di kawah ini sama bahayanya dengan lontaran material padat dari letusan gunung.

Surono yang pada Jumat (14/2/2014) diangkat menjadi Kepala Badan Geologi, mengatakan lontaran air dari danau kawah, bila masih ada, bisa mencapai sekitar 37,5 kilometer. Sudah air panas, bercampur magma, masih dipadukan dengan seratusan juta ton material padat yang terlontar.

Kira-kira, karena tak ada catatan sejarahnya, itulah yang terjadi pada letusan 1586. Namun, bukan pula letusan itu saja yang menyebabkan korban jiwa mencapai lebih dari 10.000 jiwa. Dampak sesudah letusan, tak kurang buruknya.

Diduga, kematian puluhan ribu orang itu juga disebabkan kelaparan. Dengan muntahnya air danau kawah, lontaran material padat, dan abu vulkanik yang mematikan tanaman, dapat diduga tak ada pasokan makanan yang bisa disediakan dalam jumlah besar untuk jumlah warga pada saat itu.

Membaca simbol tradisi lisan untuk mitigasi bencana

Inilah yang kemudian diduga sebagai penyebab benar-benar paripurnanya sejarah kerajaan Majapahit, menutup beragam konflik politik internal zaman itu, maupun legenda kutukan Lembu Sura. 

Sebagai gambaran,

letusan pada 1919

 yang notabene relatif lebih modern dibandingkan kondisi pada 1586, juga menewaskan ribuan orang.

Angka yang tercatat adalah 5.160 orang. Letusan pada 1919 inilah yang mengawali dilanjutkannya upaya pembangunan terowongan di kaki gunung berketinggian 1.731 meter tersebut.

Terowongan-terowongan tersebut berfungsi mengurangi volume air di kawah danau.

Catatan tertua tentang upaya mengurangi dampak dari lahar cair, gabungan magma dan air danau yang mendidih, adalah “kelahiran” Sungai Harinjing yang sekarang dikenal sebagai Sungai Sarinjing di Desa Siman, Kecamatan Kepung, Kediri. Sungai ini merupakan sudetan dari Sungai Konto.

Kehadiran Sungai Serinjing tercatat dalam prasasti Harinjing di Desa Siman.

Dalam prasasti yang dikenal pula sebagai Prasasti Sukabumi itu, tertera angka tahun 921 M.

 

 

Di situ diceritakan soal pembangunan bendungan dan sungai yang dimulai pertama kali pada 804 M. 

Terowongan pengalir air dari danau kawah buatan 1926,

Pada 19 Mei 1919,

Gunung Kelud meletus, menewaskan sedikitnya 5.000 orang, sebagian besar dari mereka tewas karena diterjang lahar panas.

 

setelah letusan pada 1919,

masih berfungsi sampai sekarang.

Setelah cukup tenang selama beberapa puluh tahun, Kelud kembali aktif pada 1951, 1966,

 Namun, setelah letusan 1966,

 Pemerintah Indonesia membangun terowongan baru yang lokasinya 45 meter di bawah terowongan lama. 

Terowongan baru yang rampung dibangun pada 1967 ini diberi nama Terowongan Ampera.

 Fungsinya menjaga volume air danau kawah tak lebih dari 2,5 juta meter kubik. Volume air di kawah Gunung Kelud susut dan hanya menyisakan genangan pada letusan efusif 2007.

Letusan gunung kelud  1990,

yang secara total menewaskan 250 orang.

 

Pada letusan Kamis (13/2/2014) malam,

air danau bisa jadi bukan lagi ancaman.

Namun, terbukti pada malam itu bawa Gunung Kelud masih memiliki ciri letusan eksplosif.

 Lontaran material padat vulkanik pada letusan terbesar pada pukul 23.30 WIB mencapai ketinggian 17 kilometer, ketika letusan pertama melontarkan material hingga setinggi 3 kilometer.

Jangkauan abu vulkanik letusan Gunung Kelud pada malam itu pun menyebar luas mengikuti arah angin, menyebar luas di Jawa Tengah dan menjangkau Jawa Barat.

 Bisa jadi gabungan antara pembangunan saluran-saluran air yang telah menghadirkan 11 sungai berhulu di gunung itu, letusan efusif yang menyurutkan air danau kawah, dan persiapan yang lebih baik menjadi faktor yang meminimalkan jumlah korban.

Namun, barangkali pekerjaan rumah tetap belum habis.

Berdasarkan catatan sejarah, Gunung Kelud memiliki pola letusan berjeda pendek, antara 9 sampai 25 tahun.

Walaupun korban jiwa yang jatuh dalam dua hari ini bukan karena dampak langsung letusan, tetapi fakta sangat pendeknya tenggat waktu antara peningkatan status Awas sampai terjadi letusan pada Kamis malam, tetap merupakan sebuah catatan baru.

Jarak waktu peningkatan status hingga terjadinya letusan, tak sampai dua jam. Kalaupun kutukan Lembu Sura tak lagi relevan sebagai mitos, barangkali perlu dibaca ada simbol-simbol budaya dalam tradisi lisan sebagai “kode” mitigasi bencana. 

Percaya atau tidak, hari ini selain 11 sungai ada di Kediri, di Tulungagung pun ada Bendungan Wonorejo, dan Blitar menjadi sebidang tanah datar di kawasan yang dikelilingi danau dan sungai itu.

Agak terdengar familiar?

Betul, kalimat dalam legenda Lembu Sura.

 

The Great Plague of London 1665 – 1666 

Great London Plague 2

© Unknown

It’s been estimated that the Great Plague of London killed roughly 100,000 people within the span of about a year. There had been numerous smaller plagues raging throughout Europe in the preceding decades, but none compared with the Great Plague that centered on London during 1665-1666. As historians tell it, the Great Plague started in July of 1665 and persisted until September of 1666, right up until the Great Fire of London destroyed most of the city’s center. After this time, the city was deemed tolerable and the nobility, who had scurried off to the countryside at the first hints of an outbreak, returned to London. 

If you’ve ever heard the classic children’s song and game ‘Ring a ring of rosies’, then you’ve basically heard a description of what this particular plague was like since the song originated during this time. The original lyrics to this song wer

Ring a ring of rosies 
A pocketful of posies 
Atishoo, atishoo 
We all fall down!

One of the initial symptoms of the plague included a rose-colored rash in the shape of a ring. Pocket full of posies signified herbs that people would stuff in their pockets since many believed that the plague was carried by bad smells. “Atishoo” was the sound of the violent sneezing, another common symptom. “We all fall down!” Well, I think you can guess what that signifies. 

In any event, with mortality rates reaching record numbers during the Great Plague, the citizens of London were forced to take desperate measures. To add insult to injury, many of the city’s physicians, priests and others who were trained to handle the sick and dying simply up and left, not returning until after the worst was over. The poorest classes were left behind to suffer and deal with the sickness and dead bodies in whatever ways they could. With most of the trained physicians gone, people were forced to take their health into their own hands and find viable remedies to ward off the plague. You can imagine there must have been a strong ‘selection pressure’ with all those people dying, weeding out the useless remedies that offered no protection. So for the folks that did manage to weather the plague, did they have some common remedy that gave them protection? 

The gravediggers probably had the worst time of all trying to stay healthy during this time. Having to handle the bodies of the dead, they were easily infected and many did not live long. In the book A Journal of the Plague Year, written by Daniel Defoe, he recounts the story of a gravedigger named John Hayward who managed to survive the Great Plague by his own special method. As it states:

He never used any preservative against the infection, other than holding garlic and rue in his mouth, and smoking tobacco

. This I also had from his own mouth. And his wife’s remedy was washing her head in vinegar and sprinkling her head-clothes so with vinegar as to keep them always moist, and if the smell of any of those she waited on was more than ordinary offensive, she snuffed vinegar up her nose and sprinkled vinegar upon her head-clothes, and held a handkerchief wetted with vinegar to her mouth.

Okay, now this is interesting. Apparently, tobacco was part of his secret. But could this just be a fluke? After all, he also employed garlic and rue, and his wife used vinegar to protect herself as well.

 
 
The protection could have come from any of those substances. But as history shows, he wasn’t the only one who believed that tobacco offered some protection from the plague. According to one website which summarizes the history of the Great Plague:

Those who stayed in London did all they could to protect themselves from the plague. As no one knew what caused the plague, most of these were based around superstition. In 1665 the College of Physicians issued a directive that brimstone ‘burnt plentiful’ was recommended for a cure for the bad air that caused the plague. Those employed in the collection of bodies frequently smoked tobacco to avoid catching the plague. 

“For personal disinfections nothing enjoyed such favour as tobacco; the belief in it was widespread, and even children were made to light up a reaf in pipes. Thomas Hearnes remembers one Tom Rogers telling him that when he was a scholar at Eton in the year that the great plague raged, all the boys smoked in school by order, and that he was never whipped so much in his life as he was one morning for not smoking. It was long afterwards a tradition that none who kept a tobacconist shop in London had the plague.” – A J Bell writing in about 1700.

Did I just read that right? Children forced to smoke tobacco; actually whipped for not smoking? Can you imagine a whole classroom of elementary school children lighting up a reef in class? Well, I can’t. Not with all the anti-tobacco programming and disinformation we hear incessantly today. But there you have it! There seemed to be a widespread belief that tobacco protected people from whatever this plague was that was going around; enough of a belief anyways for people to force their children to smoke! It seems reasonable, given the environmental pressures at the time, that the belief in tobacco as a protective remedy against the plague was more than just a trite superstition. 


I hope that wasn’t too much of a shock to read, I know it was for me when I first came across it! I think this is probably enough to drive most people’s emotional reasoning into overdrive. After all, the anti-smoking mafia has beaten it into our heads that smoking tobacco is so bad that allowing a child to smoke is equivalent to murder. But perhaps children should be exposed to tobacco smoke at an early age, or at least allowed the chance to get some second-hand smoke? It might have other beneficial effects as well. Keep in mind, I’m talking about the smoke of pure natural tobacco, not commercial cigarettes which are loaded with a lot of other chemical junk. 

I realize this is a ‘hot-button’ topic as far as children and smoking goes, but perhaps it’s high time we have this discussion in our culture. I mean, there’s more than enough evidence to suggest that the worldwide campaign to stamp out tobacco is a bit suspicious to say the least. Consider for, example, the fact that the global rate of cancer (with lung cancer second on the list) has increased by 20% over the past 10 years, yet during the same period the number of smokers dropped (as a result of government propaganda) by large percentages in many countries around the world. Consider also the fact that the rate of lung cancer among non-smokers is on the rise. In places like Dehli in India, for example, one third of people with lung cancer are non-smokers. All of this data strongly suggests that the ‘books have been cooked’ on cancer and smoking and some seriously biased science is being promoted by governments. Why? 

Given the above historical data on tobacco during the times of the Great Plague, we might speculate that tobacco’s potentially life-saving properties during a plague are one of the main reasons why the PTB want to see tobacco banished in addition to everything else. So without tobacco, people are not only stressed out and unable to think straight, they might also be more prone to pandemic diseases as well. What a set-up! 

Since we now suspect tobacco might actually have been an effective remedy against the plague, could there be any modern-day scientific evidence to support this conjecture? Part of the problem is that there is much debate over what exactly caused the plague. According to modern historians, the Great Plague of London was caused by the same bug responsible for the Black Death in Europe that started around 1347 AD. The claim in both cases is that bubonic plague, or the bacterium Yersinia pestis, passed onto people by fleas from rats, was responsible for the outbreak of disease in both instances (and many others too). However, as Gabriela Segura, M.D. states in her article “New Light on the Black Death: The Viral and Cosmic Connection“, there is much evidence that rules out this theory:

[Susan Scott and Christopher Duncan in their book Return of the Black Death] explain how Yersinia pestis has never persisted in any European rodents because they are not resistant. In addition to that, the only species of rats in Europe came either some 60 years after the last European plague or could not survive without a warm climate, making it impossible to spread infection rapidly and wildly in winter. They argue that:

… it is known that the Black Death was carried across the sea to Iceland and that there were two severe and well-authenticated epidemics in the fifteenth century. […] Yet it is known that no rats were present on the island during the three centuries of the Black Death. Infections continued through the winter when the average temperature was below -3 degrees Celsius, where transmission by fleas is impossible. It is also agreed that there is no mention in any of the accounts of rat mortality during the Black Death. A temperature of between 18 degrees and 27 degrees Celsius and relative humidity of 70% are ideal for flea egg-laying, whereas temperatures below 18 degrees inhibit it. Researchers had collected all the available climatological data for central England during the Black Death and at no time was the average July-August temperature above 18.5 degrees Celsius.

Scott and Duncan note certain factors that narrow the causative agent of the Black Death down to a virus. The infectious agent also appeared to have been remarkably stable; if there were mutations, these didn’t change the course of the disease, at least not for 300 years. The plague was believed to have been passed by droplet infection; it was considered to be safe if one kept at least 4 meters (13 feet) away from an infected person out-of-doors. Most interesting of all, there exists a strong genetic selection among European populations in favor of the CCR5-Δ32 mutation. This mutation results in the genetic deletion of a portion of the CCR5 gene which codes for a protein that is an entry port used by some viruses. This mutation makes a homozygous carrier resistant to HIV-1 virus infections, and may have made them resistant to the Black Death. 

No known virus existing today is responsible for the Black Death, although the symptoms resemble those of Ebola, Marburg and the viral hemorrhagic fevers – diseases caused by filoviruses. They have a high mortality rate and tend to occur in explosive epidemics driven by person-to-person transmission. Outbreaks occur unpredictably and, as of yet, no animal reservoir is known.

So apparently the maligned rats and fleas are off the hook, but there still seems to be some question over what particular bug caused the Black Death. A virus certainly fits the bill, but perhaps once infection sets in, certain forms of bacteria would take hold as well? Kind of like how the common flu can sometimes lead to pneumonia in a weakened patient. So is there any evidence that tobacco or any of its components have an antimicrobial or antiviral effect? Although scientific data on this subject is hard to come by given the skewed tunnel vision with which corrupted science views tobacco, there is nonetheless some research which points to tobacco being anti-microbial. 

Antiviral Activity of Tobacco Smoke Condensate on Encephalomyocarditis Infection in Mice 

This study shows that cigarette smoke had an inhibitory effect on the growth of “EMC virus, vesicular stomatitis virus, reovirus type 2, vaccinia virus, and poliovirus type 2, but not against adenovirus type 12, in KB cell cultures.” 

The effect of chronic exposure to tobacco smoke on the antibacterial defenses of the lung. 

From the abstract:

… These studies indicate that chronic exposure to tobacco smoke does not impair, and in fact may stimulate, the host defenses of the lung…

And probably most intriguing of all: 

Antimicrobial activity of nicotine against a spectrum of bacterial and fungal pathogens

… Nicotine caused a dose-dependent growth inhibition of a broad spectrum of the test organisms, some of which are known pathogens. Gram-positive and gram-negative bacteria were affected equally, along with the acid-fastMycobacterium phlei and the opportunistic fungi Candida albicans and Cryptococcus neoformansthereby suggesting a common mechanism of action. Levels of inhibition >50% occurred when most of the affected organism were cultured with nicotine at 100-250 µg/ml. It is noteworthy that such concentrations of nicotine can be found in vivo [3], especially in the oral cavity of smokeless tobacco users, making these findings physiologically relevant. It should also be noted that theviridans steptococci used in these experiments – which were also highly susceptible to the effects of nicotine – are an almost universal inhabitant of the oropharynx. In contrast, Staphylococcus aureus and the spirochaete B. burgdorferi (the agent of Lyme disease), were only slightly inhibited or were completely unaffected following the exposure to nicotine.

So it appears that tobacco does have a broad anti-microbial effect that has so far has been only marginally explored. Could we be seeing hints from these studies as to why London residents took to tobacco as their remedy of choice against the plague – even to the point of forcing their children to smoke? Certainly, more research in this area would be good. 

Now, keep in mind that we’re not claiming that people can go smoke tobacco and then become impervious to pandemics, plagues, etc. At best, tobacco looks like a helpful tool to have in one’s arsenal. With the current toxic state of our world, proper diet and detoxing are going to be essential to maintaining health during these trying times as well. This is already the case even without any real plague to contend with. The human immune system is quite capable of fighting off new diseases as long as it’s not working against itself by attacking healthy tissue (autoimmune disease), or stressed from having to fight off too many invaders. Keep in mind also that the immune system treats many of the anti-nutrient chemicals in plant foods just as it does a virus. So the body needs an optimal form of fuel/food to function in an adequate way; anything less just leads to problems. Indeed, more and more medical studies are pointing the finger at the ‘modern lifestyle’ with its high-carb low-fat diet (among the massive amount of pollution floating around in our atmosphere) as the main culprit in the rise in cancer rates. 

In the research we’ve gathered here at SOTT, we’ve discovered that saturated fat, particularly coming from animals, is one of the most essential forms of nourishment. A diet with a high percentage of saturated fat turns out to be a very healthy and protective diet. The membranes around our cell are made of fat and cholesterol and our brain is made of the same stuff. What should this tell us? A healthy cell membrane protects cells from viral invaders, just like a healthy brain makes it difficult to believe lies (i.e. thought viruses). And no, we’re not suggesting that people go and load up on junk food, which provides the wrong kind of fat anyway; most of the fat used in processed foods is soy, corn or canola oil and is damaging to our bodies. For more on the story of fat, see the article Everything About Fat by Sott.net’s Doug DiPasquale. 

So are you feeling that emotional reasoning kick in yet? Don’t worry, you’re not alone. Many of us have had to get past the widely-held belief that animal fat is supposed to be bad for us. So please take this slow, read the links carefully and let the ideas percolate a bit before coming to any judgment on the matter. And don’t take our word for it, do the research yourself and come to your own conclusions! 

TEN TERRIBLE FEMINES IN THE WORLD

10. Great Famine Ireland
            1.5 million dead, 2 million emigrated
 
 
One of the most famous famines in history, the Great Famine was caused by a devastating potato disease. 33% of the Irish population relied on the potato for sustenance, and the onset of the disease in 1845 triggered mass starvations that lasted until 1853. The large Catholic population was suppressed by British rule, and left unable to own or lease land, or hold a profession. When the blight struck, British ships prevented other nations from delivering food aid. Ireland experienced a mass exodus, with upwards of 2 million people fleeing the country, many to the United States. At its conclusion in 1853, 1.5 million Irish were dead, and an additional 2 million had emigrated. In total, the population of Ireland shrunk by a resounding 25%.
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9. Vietnamese Famine of 1945
 
 
As a protectorate under France, Vietnam was under colonial rule for much of World War II. As Japanese expansion began in Indochina, Vietnam was taken for the Japanese, and a collaborationist French government sided with the Japanese. Agricultural focus shifted from sustenance to war-materials, specifically rubber. The Japanese exploited what little crop farms remained, and the invading forces commandeered most of these crops. This, teamed with an unbearable drought followed by biblical flooding, caused mass starvation across much of Northern Vietnam. The resulting famine killed 2 million Vietnamese.
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8. North Korean Famine
               3 million dead
 
 
As the most recent famine on this list, North Korea suffered a tremendous famine from 1994 to 1998, brought about by a combination of misguided leadership and large scale flooding. Torrential rains in 1995 flooded the farming regions, and destroyed 1.5 million tons of grain reserves. Politically, Kim Jung Il implemented a “Military First” policy, which placed the needs of the military above the needs of the common people, food rations included. The isolated nation suffered from a stagnating economy, and was unable and unwilling to import food. As such, the childhood mortality rate rose to 93 out of 1000 children, and the mortality rate of pregnant women rose to 41 out of 1000 mothers. Over a 4-year span, an estimated 2.5-3 million people perished due to malnutrition and starvation.
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7. Russian Famine of 1921
               5 million dead
 
 
The early 20th century was a tumultuous time for Russians, as they lost millions in World War I, experienced a violent revolution in 1917, and suffered from multiple Civil Wars. Throughout the wars, the Bolshevik soldiers often forced peasants to sacrifice their food, with little in return. As such, many peasants stopped growing crops, as they could not eat what they sowed. This resulted in a massive shortage of food and seed. Many peasants had taken to eating seeds, as they knew they could not eat any crops they grew. By 1921, 5 million Russians had perished.
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6. Bengal Famine of 1943
               7 million dead
 
 
The Bengal Famine of 1943 was set about by a whirlwind of catastrophic events. With World War II raging and Japanese imperialism growing, Bengal lost their largest trading partner in Burma. A majority of the food the Bengalis consumed was imported from Burma, but the Japanese suspended the trade. In 1942, Bengal was hit by a cyclone and three separate tidal waves. The ensuing floods destroyed 3200 square miles of viable farmland. An unpredictable fungus, destroying 90% of all rice crops in the region, then struck crops. Meanwhile, refugees fleeing the Japanese from Burma entered the region by the millions, increasing the need for food supplies. By December of 1943, 7 million Bengalis and Burmese refugees were dead due to starvation.
 

–>  

5. Bengal Famine of 1770
               10 million dead
 
 
Yet another famine in Bengal, this horrific event killed a third of the population. Largely ruled by the English-owned East India Company, reports of severe drought and crop shortages were ignored, and the company continued to increase taxes on the region. Farmers were unable to grow crops, and any food that could be purchased was too expensive for the starving Bengalis. The company also forced farmers to grow indigo and opium, as they were much more profitable than inexpensive rice. Without large rice stocks, people were left with no food reserves, and the ensuing famine killed 10 million Bengalis.
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4. Soviet Famine of 1932-1933
             10 million dead
 
 
 
Incredibly, the severity of this famine was not fully known in the West until the collapse of the USSR in the 1990s. The main cause was the policy of collectivization administered by Josef Stalin. Under collectivization, large swaths of land would be converted into collective farms, all maintained by peasants. Stalin went about implementing this by destroying the peasants existing farms, crops, and live-stock, and forcibly taking their land. Reports of peasants hiding crops for individual consumption led to wide-scale search parties, and any hidden crops found were destroyed. In actuality, many of these crops were simply seeds that would be planted shortly. The destruction of these seeds and the forced collectivization of land caused mass starvation, killing an estimated 10 million people.
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3. Chalisa famine
              11 million dead
 
 
 
The Chalisa famine refers to the year in the Vikram Samvat calendar used in Northern India. Occurring in 1783, the region suffered from an unusually dry year, as a shift in the El Nino weather system brought significantly less rain to the region. Vast swaths of crops withered and died, and livestock perished due to lack of food and drinking water. The tumultuous year killed 11 million Indians.
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2. Chinese Famine of 1907
              25 million dead
 
 
Ranking second in terms of death toll, the Chinese Famine of 1907 was a short-lived event that took the lives of nearly 25 million people. East-Central China was reeling from a series of poor harvests when a massive storm flooded 40,000 square miles of lush agricultural territory, destroying 100% of the crops in the region. Food riots took place daily, and were often quelled through the use of deadly force. It is estimated that, on a good day, only 5,000 were dying due to starvation. Unfortunately for the Chinese, this would not be their last great famine.
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1. Great Chinese Famine
              43 million dead
 
 
Much like the Soviet Famine of 1932-1933, the Great Chinese Famine was caused by Communist leaders attempting to force change upon an unwilling population. As part of their “Great Leap Forward”, the owning of private land was outlawed in China in 1958. Communal farming was implemented in an attempt to increase crop production. More relevant, however, was the importance the Communist Regime placed on iron and steel production. Millions of agricultural workers were forcibly removed from their fields and sent to factories to create metal.
In addition to these fatal errors, Chinese officials mandated new methods of planting. Seeds were to be planted 3-5 feet under the soil, extremely close together, to maximize growth and efficiency. In practice, what little seeds that sprouted were severely stunted in growth due to overcrowding. These failed policies, teamed with a flood in 1959 and a drought in 1960, affected the entirety of the Chinese nation. By the time the Great Leap Forward had ended in 1962, 43 million Chinese had died from the famine.

 

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beragam sumber

 

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